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Capsules of multienzyme combination

A technology for capsules and pancreatic enzymes, applied in the directions of capsule delivery, drug combination, digestive system, etc., can solve the problems of unstable product storage, poor enzyme stability, complicated operation, etc., and achieve flexible prescription, good enzyme activity, and simplified preparation process. Effect

Inactive Publication Date: 2005-01-12
北京奥路特生物医药研发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] 3. The enzyme stability in the multi-enzyme tablet is poor, and its validity period is only one year, but in many cases it does not meet this requirement
Five of these enzymes are proteases. According to the quality standards of pharmaceuticals, the substrates used in the determination of proteases in papain, bromelain and trypsin are all casein, and papain can also hydrolyze the specific substrate BAEE of trypsin. (N-benzoyl-L-arginine ethyl ester), therefore, when measuring the activity of a single enzyme in Wobenzym, these components interfere with each other, and inhibitors must be used, which makes the operation complicated and the cost is high
In addition, a variety of enzymes hydrolyze each other, resulting in unstable product storage

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Take by weighing papain 35g, auxiliary material comprises mannose 40g, starch 160g, mix, pass through 80 mesh nylon sieves and mix three times again, after adding water to make soft material, cross 40 mesh nylon sieves to make granules, dry naturally at room temperature, at 60 Dry at ℃ for 2 hours, pass through a 40-mesh nylon sieve for granulation, and press 1000 pieces;

[0026] Weigh 90g bromelain, auxiliary materials include lactose 150g, starch 100g, mix, pass through 80-mesh nylon sieve and mix three times, add water soft material, pass through 40-mesh nylon sieve to make granules, dry naturally at room temperature, and dry at 60°C After 2 hours, pass through a 40-mesh nylon sieve for granulation, and press 1000 pieces;

[0027] Weigh 4g of chymotrypsin, 13g of trypsin, 50g of rutin, and 150g of auxiliary material starch, mix, make soft material, granulate, dry, granulate, and make 1000 tablets;

[0028] Weigh 90 g of pancreatic enzymes, supplementary materials i...

Embodiment 2

[0032] Take bromelain 50g, auxiliary material starch 70g, mix, make soft material, granulate, dry, granulate, make 1000 pieces;

[0033] Weigh 26g of papain, 15g of trypsin, 3g of chymotrypsin, 75g of auxiliary material starch, mix, make soft material, granulate, dry, granulate, and make 1000 tablets;

[0034] Weigh 80g of pancreatin, 150g of auxiliary materials glucose, 7g of magnesium stearate, mix, make soft material, granulate, dry, granulate, and make 1000 tablets;

[0035] Weigh 50g of rutin, 80g of mannose as an auxiliary material, mix, make soft material, granulate, dry, granulate, and make 1000 tablets;

[0036] Take one piece of each of the above four small tablets, fill them with No. 0 or No. 00 enteric-coated capsules, and make a total of 1,000 capsules; or wrap the four kinds of small tablets with enteric coatings, and then fill them with No. 0 or No. 00 ordinary capsules, and make a total of 1,000 capsules.

[0037] The characteristic of this embodiment is that ...

Embodiment 3

[0039] Weigh 35g of papain, 60g of auxiliary material starch, mix, make soft material, granulate, dry, granulate, and make 1000 tablets;

[0040] Weigh 95g bromelain, 120g lactose as auxiliary material, mix, make soft material, granulate, dry, granulate, and make 1000 tablets;

[0041] Weigh trypsin 24g, chymotrypsin 1g, rutin 50g, auxiliary material starch 150g, mix, make soft material, granulate, dry, granulate, make 1000 pieces;

[0042] Weigh 85g of trypsin, 120g of pregelatinized starch as an auxiliary material, mix, make soft material, granulate, dry, granulate, and make 1000 tablets;

[0043] Take one piece of each of the four kinds of small tablets, fill them with No. 0 or No. 00 enteric-coated capsules, and make 1,000 capsules in total; or wrap the four kinds of small pieces with enteric-coated coatings, and then fill them with No. 0 or No. 00 ordinary capsules, and make 1,000 capsules in total.

[0044] The feature of this embodiment is that five kinds of enzymes an...

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PUM

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Abstract

A combined multi-enzyme capsule is composed of the shell and the core consisting of one or two anti-inflammatory enzymes and auxiliary.

Description

field of invention [0001] The invention belongs to the technical field of pharmaceutical dosage forms and preparations, in particular to the improvement of dosage forms of multi-enzyme preparations. Background of the invention [0002] Enzymes are a class of biologically active macromolecular substances from organisms, which have the characteristics of specificity, specificity, and mildness. Enzymes can be used to prepare medicines for treating indigestion, inflammation and other diseases. Since enzymes belong to macromolecular proteins, they are sensitive to environmental factors such as temperature and pH value, and are easy to denature and inactivate, so the technical requirements for preparations are relatively strict during the preparation process. [0003] The multi-enzyme tablet currently produced is a compound preparation composed of pepsin and pancreatin, and is a double-layer coated tablet preparation with enteric coating and sugar coating. It is used for dyspeps...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K38/43A61P1/14A61P29/00
Inventor 郑昌学杨亚波黄伟
Owner 北京奥路特生物医药研发有限公司
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