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Gingseng and ginkgo injection and its preparation

A technology for injection and water for injection, which is applied in the direction of medical formulas, medical preparations containing active ingredients, cardiovascular system diseases, etc., and can solve the problems of inappropriate severe and acute attack patients, slow drug effect and low bioavailability and other problems, to achieve the effect of fast drug effect, fast drug absorption and high bioavailability

Inactive Publication Date: 2005-02-23
四川三民药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These medicaments made of single ginkgo leaf extract or ginkgo leaf extract and chemical agents have been proved by the applicant's pharmacodynamic tests: their activity is lower than that of the compound drug of red participation ginkgo leaf extract
However, the Gincosan ginkgo red ginseng extract oral capsule abroad has the disadvantages of low bioavailability, low blood drug concentration, slow drug effect, and more drug waste. It is only suitable for mild and chronic patients and is not suitable for use. Severe and acute exacerbation patients

Method used

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  • Gingseng and ginkgo injection and its preparation
  • Gingseng and ginkgo injection and its preparation
  • Gingseng and ginkgo injection and its preparation

Examples

Experimental program
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preparation example Construction

[0041] d, the preparation process of hydrogenated ginkolic acid reference substance

[0042] Take the exocarp of ginkgo fruit dried at 60°C-70°C, and use ethanol to reflux extract at 60°C-70°C for 2-4 times. For the first time, use 4-8 times the amount to extract for 2-5 hours, and for the second time, use 3-6 times Extract multiple times for 2 to 4 hours, combine the extracts, recover ethanol under reduced pressure at 60°C to 90°C, put the concentrated solution on a D101 macroporous resin column, and first elute with about 2500ml of 50% to 70% ethanol. About 3-4 drops per second until the eluent is clear; then elute with 5000ml of 65%-85% ethanol, collect the ethanol eluate, recover ethanol under reduced pressure at 60°C-90°C, and concentrate it to near dryness , add 200-300ml of methanol to dissolve slightly, add 10% activated carbon to adsorb for about 15 minutes, stir 2-3 times during this period, filter and decarbonize, wash the filter with 80-120ml of methanol three time...

Embodiment A

[0044] Embodiment A small volume Shenyin injection:

[0045] Red ginseng or ginseng 1-3g extract (that is, ginsenoside content 1.2-3.6mg, ginseng polysaccharide content 25-75mg), ginkgo leaf extract 40-120 mg, total weight of the composition 8%-16% ethanol, injection Add water to 5-20 ml to form.

[0046] Example 1 It consists of 1g extract of red ginseng (ginsenoside 1.2mg, ginseng polysaccharide 25mg), ginkgo biloba extract 40mg, ethanol 0.4ml, and water for injection to 5ml.

[0047] Example 2 Red ginseng extract 2g (ginsenoside 2.4mg, ginseng polysaccharide 50mg), ginkgo biloba extract 80mg, ethanol 0.8ml, water for injection added to 10ml composition.

[0048] Example 3 consists of 3g of red ginseng extract (3.6mg of ginsenosides, 75mg of ginseng polysaccharide), 120mg of ginkgo biloba extract, 1.6ml of ethanol, and 20ml of water for injection.

[0049] Example 4 consists of 2 g of ginseng extract (2.4 mg of ginsenoside, 50 mg of ginseng polysaccharide), 80 mg of ginkgo...

Embodiment B

[0058] Embodiment B Large-capacity ginseng silver sodium chloride injection:

[0059] Red ginseng or ginseng 1 ~ 3g extract (ie ginsenoside 1.2 ~ 3.6mg, ginseng polysaccharide 25 ~ 75mg), ginkgo leaf extract 40 ~ 120mg, sodium chloride of 0.9% of the total composition, water for injection is added to 100 --200ml composition.

[0060] Example 1 It consists of 1g extract of red ginseng (ginsenoside 1.2g, ginseng polysaccharide 25mg), ginkgo leaf extract 40mg, sodium chloride 0.45g, and water for injection to 50ml.

[0061] Example 2 It consists of 2g extract of red ginseng (2.4g ginsenoside, 50mg ginseng polysaccharide), 80mg ginkgo leaf extract, 0.9g sodium chloride, and water for injection to 100ml.

[0062] Example 3 consists of 3g of red ginseng extract (3.6g of ginsenosides, 75mg of ginseng polysaccharide), 120mg of ginkgo biloba extract, 1.8g of sodium chloride, and 200ml of water for injection.

[0063] Example 4 Consists of 2 g of ginseng extract (2.4 g of ginsenosides...

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Abstract

A Chinese medicine in the form of injection, powder injection, or perfusion for treating cerebral apoplexy and its sequelae, and the angina pectoris caused by obstruction of Qi in chest is prepared from red ginseng, gingko leaf, auxiliary and water for injection. Its preparing process is also disclosed, which includes extraction of ginseng polyose and gensenoside from red ginseng.

Description

technical field [0001] The invention relates to a medicine for treating ischemic cardiovascular and cerebrovascular diseases, in particular to a medicine made of red ginseng or ginseng and ginkgo leaf extract, which can improve cerebral ischemia and myocardial ischemia, and improve cardiac hemodynamics. , reducing myocardial oxygen consumption, improving microcirculation, inhibiting arterial thrombus formation, a new drug for intravenous injection used to treat cerebral ischemic stroke and stroke sequelae, chest pain and heart pain syndrome - Shenyin injection and its preparation method. Background technique [0002] Coronary atherosclerotic heart disease, referred to as coronary heart disease, is the most important chronic disease in industrialized countries. Taking the United States as an example, 600,000 people die from coronary heart disease every year, and the cost of treating coronary heart disease is about 5 billion US dollars. In the past 20 years, the incidence of c...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K9/19A61K31/715A61P9/10
Inventor 罗明生高天惠
Owner 四川三民药业有限公司
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