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Procaterol dripping pill and its preparing method

A technology of procaterol and dropping pills, which is applied in the field of procaterol preparations, can solve the problems of slow onset of oral preparations, inability to be widely used, inconvenient use, etc., and achieve the effect of easy quality control, good stability and low price

Inactive Publication Date: 2005-03-02
ZHEJIANG ACAD OF MEDICAL SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Existing tablet, buccal tablet, capsule, granule, aerosol, suppository etc. in the domestic procaterol hydrochloride preparation market at present, the onset of oral preparation is slow, and suppository Chinese is difficult for accepting, and it is inconvenient to use, although aerosol Faster onset, but expensive, not widely available

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Procaterol hydrochloride 0.2g

[0029] Macrogol 4000 50.0g

[0030] Polyethylene glycol 6000 150.0g

[0031] Macrogol 400 20.0g

[0032] Saccharin 0.1g

[0033] Menthol 2.0g

[0034] Sodium metabisulfite 2.0g

[0035] Tween 80 10.0ml

[0036] Put polyethylene glycol 4000 and polyethylene glycol 6000 in a chemical pot and melt in a water bath at 75°C. Separately take procaterol hydrochloride, sodium metabisulfite, saccharin, polyethylene glycol 400, and Tween 80, stir well, and ultrasonicate for 10 minutes. Add to the above molten liquid, stir evenly, then add menthol, stir evenly, transfer to a liquid storage tank, keep warm at 75-80°C, drop into methyl silicone oil at 10-20°C, collect drop pills, and obtain. Each pill weighs about 40mg, and each pill contains 35μg of medicine, and the total dissolution time is 2 minutes.

Embodiment 2

[0038] Procaterol Hydrochloride 0.15g

[0039] Polyethylene glycol 6000 200.0g

[0040] Sodium bisulfite 2.0g

[0041] Mannitol 5.0g

[0042] Menthol 0.1g

[0043] Tween 80 10.0ml

[0044] Take polyethylene glycol 6000 and melt it in a water bath at 75°C in a chemical tank, then take Procaterol hydrochloride, sodium bisulfite, mannitol, and Tween 80 and mix well, add to the above melt, stir well, and then add menthol Stir well. Transfer to a liquid storage tank, seal it and keep it warm at 75-80°C, drop it into methyl silicone oil at 10-20°C from top to bottom, collect the dripping pills, and obtain the product. Each pill weighs about 40 mg, contains 25 μg of medicine, and takes 2 minutes to completely dissolve.

Embodiment 3

[0046] Procaterol Hydrochloride 0.15g

[0047] Sodium stearate 200.0g

[0048]Thiourea 2.0g

[0049] Sorbitol 5.0g

[0050] Menthol 0.1g

[0051] Sodium stearate is heated and melted in a water bath, procaterol hydrochloride, sorbitol and thiourea are added, stirred evenly, and then menthol is added. Transfer to a liquid storage tank, seal it and keep it warm at 75-80°C, drop it into methyl silicone oil at 10-20°C, collect the dripping pills, dry them in a lime jar, and obtain. Each pill weighs about 40mg, and each pill contains 25μg of medicine, and the total dissolution time is 3 minutes.

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PUM

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Abstract

The present invention relates to procaterol preparation, and especially one new kind of procaterol dripping pill for treating bronchial asthma, asthma bronchitis and chronic obstructive lung diseases and its preparation process. The medicine releasing rate of procaterol may be regulated via selecting different dripping pill matrix, composition and coating material. The preparation may contain stabilizer and corrective, the dripping pill may have or have no coating, and the dripping pill may be held under tongue or orally taken with completely dissolving and dispersing time of 1-15 min. The present invention has simple preparation process, controllable quality, high stability and convenient use.

Description

technical field [0001] The invention relates to a novel procaterol preparation, in particular to a procaterol drop pill for treating bronchial asthma, asthmatic bronchitis and chronic obstructive pulmonary disease and a preparation method thereof. Background technique [0002] Asthma is a common and frequently-occurring disease of the respiratory tract. There are nearly 200 million patients in the whole world at present, and the prevalence rate in my country accounts for 5%, and the number of patients is more than 10 million, and its incidence rate increases at a rate of 5%, and half of them are onset before the age of 12. It is a disease that seriously endangers people's physical and mental health, weakens working ability, and reduces the quality of life, and it is difficult to be cured. Therefore, the development of antiasthmatic drugs is highly valued both at home and abroad. [0003] The chemical name of Procaterol is: 5-(1-hydroxy-2-isopropyl...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/4704A61P11/00A61P11/06
Inventor 陈国神张望刚蒋晓萌黄金龙施存元
Owner ZHEJIANG ACAD OF MEDICAL SCI
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