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Dioscin oral disintegration tablet and its preparing method

A technology of diosgenin and angina pectoris, which is applied in the field of diosgenin orally disintegrating tablets and its preparation, and can solve the problems of lower patient compliance and long medication time

Inactive Publication Date: 2005-03-02
哈尔滨科信必成医药科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Patients need to take the medicine for a long time, and ordinary tablets need to be taken with water when taking them, which may lead to reduced patient compliance

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment one direct flavoring method

[0032] 1. Prescription

[0033] 1. Raw material - 80.0g of diosgenin;

[0034] 2. Adhesive - polyvinylpyrrolidone K-30 1.0g;

[0035] 3. Filler—microcrystalline cellulose 10.0g; mannitol 119.0g;

[0036] 4. Flavoring agent——aspartame 2.5g; orange essence 2.5g;

[0037] 5. Disintegrant—cross-linked polyvinylpyrrolidone 12.0g; L-HPC 18.0g;

[0038] 6. Glidant—micronized silica gel 2.5g;

[0039] 7. Lubricant—magnesium stearate 2.5g.

[0040] Total weight 250g, made into 1000 tablets altogether, 250mg / tablet, dioscin content 32%.

[0041] 2. Preparation method

[0042] 1) Take the dioscin raw material and pulverize it, granulate it with polyvinylpyrrolidone K-30, pass it through a 26-mesh sieve, and set aside;

[0043] 2) Pass the micropowdered silica gel, aspartame and orange essence through a 40-mesh sieve, mix evenly, then add the granulated dioscin granules, mix evenly, and set aside;

[0044] 3) Take microcrystalline c...

Embodiment 2

[0046] Embodiment two powder coating taste masking method

[0047] 1. Prescription

[0048] 1. Raw material - 80.0g of diosgenin;

[0049] 2. Coating material - Eudragit  E100 12.0g; Eudragit  NE30D (dry) 4.0g;

[0050] 3. Filling agent - mannitol 110.0g;

[0051] 4. Flavoring agent - aspartame 2.5g; mint essence 2.5g;

[0052] 5. Disintegrant—cross-linked polyvinylpyrrolidone 10.0g; L-HPC 15.0g;

[0053] 6. Glidant—micronized silica gel 6.5g;

[0054] 7. Lubricant—magnesium stearate 2.5g.

[0055] Total weight 250g, made into 1000 tablets altogether, 250mg / tablet, dioscin content 32%.

[0056] 2. Preparation method

[0057] 1) Take Eudragit  E100 and Eudragit NE30D is dissolved with more than 95% pharmaceutical industrial ethanol and diluted to a certain concentration for later use;

[0058] 2) Take dioscin and place it in a fluidized bed to boil, spray the above solution at a certain speed for powder coating to obtain dioscin powder-coated granules, dry and se...

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Abstract

The present invention relates to orally disintegrated tablet for treating and preventing coronary heart disease, angina pectoris, hyperlipemia, cerebral arteriosclerosis and other cerebral blood circulation disturbance, and especially orally disintegrated tablet of dioscin extracted from plant material yam rhizome and its preparation process. The orally disintegrated tablet is prepared with dioscin as main material, and through adding stuffing, disintegrating agent, corrective, flow assistant and other supplementary material, pressing into tablet and other steps. The present invention has the features of low production cost, fast disintegration, good taste, etc.

Description

[0001] [Technical Field] The present invention relates to a method for the treatment and prevention of coronary heart disease, angina pectoris and stagnant internal obstruction of chest pain, dizziness, chest tightness, palpitations, shortness of breath, hyperlipidemia, hyperviscosity; cerebral arteriosclerosis, The invention relates to a diosgenin preparation for stroke sequelae, vertebral-basilar artery insufficiency, and other cerebral blood circulation disorders, in particular to a diosgenin orally disintegrating tablet preparation with rapid release. [Background technique] [0002] Dioscin is extracted from medicinal plants such as Pangosia chinensis, and is a pure traditional Chinese medicine preparation refined through scientific formula. It has the characteristics of clear chemical structure, good oral absorption, and high bioavailability. Dioscin can increase coronary blood flow and myocardial nutritional blood flow, has obvious protective effect on myocardial ischemia...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/7048A61P9/10
Inventor 王锦刚
Owner 哈尔滨科信必成医药科技发展有限公司
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