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Rusco saponin element and application of its saponin in preparation of medicine preventing and treating embolus disease

A technology for ruscogenin and thrombotic diseases, applied in the field of application of ruscogenin and its saponins in the preparation of drugs for preventing and treating thrombotic diseases, capable of solving problems such as spontaneous bleeding and slow action

Inactive Publication Date: 2005-03-23
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this product acts slowly, and at the same time, it is easy to cause spontaneous bleeding in the skin, mucous membranes, gastrointestinal tract, genitourinary tract, etc.

Method used

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  • Rusco saponin element and application of its saponin in preparation of medicine preventing and treating embolus disease
  • Rusco saponin element and application of its saponin in preparation of medicine preventing and treating embolus disease
  • Rusco saponin element and application of its saponin in preparation of medicine preventing and treating embolus disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037]Preparation method of ruscogenin and saponin thereof

[0038] 1. Total saponins

[0039] Take 2 kg of dried fibrous roots of Lithopriopogon japonicus (Short Ting Mountain or Hubei Radix Ophiopogon japonicus), soak for 1 hour, decoct for 3 times, each time for 1 hour, combine the decoction liquid, settle still, take the supernatant, pass it through macroporous resin , rinse with distilled water first, discard the eluate, then rinse with 40% ethanol, discard the eluate (no saponin components after testing), then rinse with 80% ethanol, concentrate the eluate and evaporate to dryness, that is The total saponins of Ophiopogon japonicus (the total saponins of Ophiopogon japonicus brevis is abbreviated as LM-ts).

[0040] 2. Leptosponin C (LM-C) and ruscogenin

[0041] 7.0kg of Ophiopogon japonicus fibrous roots, cold-soaked in 95% ethanol for 1 month, percolated with ethanol 3 times, combined, concentrated to an extract-like extract, extracted 3 times with ethyl acetate, co...

Embodiment 2

[0044] The preparation method of embodiment 2 ruscogenin and its saponin dosage form

[0045] 1. Capsule preparation method

[0046] prescription composition

[0047] CSO 50.0g Starch 47.5g Microcrystalline Cellulose 95.5g

[0048] Appropriate amount of 5% starch slurry talcum powder 2.0g made into 1000 capsules

[0049] Preparation Process

[0050] The total saponins of Ophiopogon japonicus are crushed into fine powder, mixed with auxiliary materials, made into granules, dried, packed into capsules, and packaged for quality inspection.

[0051] 2. Tablet preparation method

[0052] prescription composition

[0053] LM-C 20g Starch 400g Starch slurry (8%) Appropriate amount Magnesium stearate Appropriate amount

[0054] Made into 1000 pieces

[0055] Preparation Process

[0056] Take LM-C and mix it with starch, use 8% starch slurry as a binder to make a soft material, pass through a 12-14 mesh sieve and granulate, dry at 70-80°C, granulate, add magnesium stearate and ...

Embodiment 3

[0063] Example 3 Research on the antithrombotic activity of ruscogenin and its saponins

[0064] 1 Experimental materials

[0065] 1.1 Drugs and reagents

[0066] LM-ts, CSO, ophiopogonin D, LM-C, ruscogenin, all with a purity of more than 80%. Aspirin enteric-coated tablets (abbreviated as ASA, Nanjing Hengsheng Pharmaceutical Factory, batch number 030304); carrageenan (Carrageenan, TypeI, Sigma, C1013); warfarin sodium tablets (Warfarin, Shanghai Jiufu Pharmaceutical Co., Ltd., batch number: 030601).

[0067] 1.2 Experimental animals

[0068] Kunming mice, male, 18-22g and 25-30g; ICR mice, male, 25-30g, provided by the animal room of Xinzhong New Drug Research Center, China Pharmaceutical University.

[0069] 2 Methods and Results

[0070] 2.1 The impact on inferior vena cava thrombosis

[0071] 2.1.1 Effect of CSO on the formation of inferior vena cava thrombosis in mice

[0072] Fifty male Kunming mice, 25-30 g, fasted for 12 hours, were divided into 5 groups, 10 m...

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Abstract

An application of ruscorectal and / or its heteroside prepared from ruscorectal and saccharide chain in preparing the medicine for preventing and treating thrombotic diseases is disclosed.

Description

technical field [0001] The invention relates to the application of ruscogenin and its saponins derived from traditional Chinese medicines in the preparation of medicines for preventing and treating thrombosis diseases, specifically the application of ruscogenin and ophiopogon saponins in the preparation of medicines for preventing and treating venous thrombosis diseases. technical background [0002] Thrombotic disease is a common disease and frequently-occurring disease, clinically, venous thrombotic disease is especially common, and the lower extremities and pelvic cavity are its predilection sites. The acute phase of deep vein thrombosis (DVT) in the lower extremities is characterized by pain, swelling, and superficial varicose veins in the affected limbs. Insufficiency, superficial dermatitis, and induration caused by fibrosis, etc., can cause gangrene and loss of working ability in severe cases, and even cause sudden death due to pulmonary embolism due to emboli falling...

Claims

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Application Information

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IPC IPC(8): A61K31/58A61K31/7048A61P7/02
Inventor 寇俊萍田友清李林洲余伯阳朱丹妮严永清
Owner CHINA PHARM UNIV
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