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Compound tobacco addict controlling plaster and its preparation method

A technology of compound recipes and cigarette stickers, which is used in the fields of tobacco, pharmaceutical formulations, and tobacco processing.

Inactive Publication Date: 2005-04-13
TIANJIN ZHAOSHI SCI & TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the practice of smoking cessation at home and abroad has proved that nicotine replacement is the only effective smoking cessation measure, so most smoking cessation methods have to use nicotine

Method used

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  • Compound tobacco addict controlling plaster and its preparation method
  • Compound tobacco addict controlling plaster and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Weigh 250g of nicotine, 100g of tyrosine, 150g of vitamin E, 10g of clove volatile oil, and 20g of peppermint oil, and disperse them in 20ml of 60-70% alcohol, stir vigorously and put them into a colloid mill, homogenizer, and nano-disperser to make micro Emulsion colloid; then add 1000g of pre-prepared skeleton gel and 500g of pressure-sensitive adhesive, i.e. the glue with a ratio of 1:2, adjust the viscosity to 5000mpas, coat and dry by a coating machine, and obtain a drug sticking film material; Pass another 20cm 2 The film is punched into a patch, put into an aluminum-plastic film bag, sealed and packaged for use.

Embodiment 2

[0035] Weigh 250g of nicotine, 100g of phenylalanine, 150g of vitamin E, 10g of clove volatile oil, and 20g of peppermint oil, disperse them in 20ml of 60-70% alcohol, stir vigorously and put them into a colloid mill, a homogenizer, a nano-disperser, and make into a microemulsion colloid; then add 1000g of pre-prepared skeleton gel and 500g of pressure-sensitive adhesive, that is, a 1:2 ratio of mucilage, the modulation viscosity is 5000mpas, coated and dried by a coating machine, the drug patch can be obtained material; then through 20cm 2 The film is punched into a patch, put into an aluminum-plastic film bag, sealed and packaged for use.

Embodiment 3

[0037] Weigh and weigh 250g of nicotine, 100g of dopa, 150g of vitamin E, 10g of clove volatile oil, and 20g of peppermint oil, and disperse them in 20ml of 60-70% alcohol, stir vigorously and put them into a colloid mill, a homogenizer, a nano-disperser, and make into a microemulsion colloid; then add 1000g of pre-prepared skeleton gel and 500g of pressure-sensitive adhesive, that is, a 1:2 ratio of mucilage, the modulation viscosity is 5000mpas, coated and dried by a coating machine, the drug patch can be obtained material; then through 20cm 2 The film is punched into a patch, put into an aluminum-plastic film bag, sealed and packaged for use.

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Abstract

The compound smoking controlling plaster is one medicated article for smoker to use. It is prepared with nicotine, dopamine precursor, vitamin E, transdermal osmosis promoter and organic solvent as main material to form the micro emulsion colloid. The preparation process includes preparing the micro emulsion colloid, adding the micro emulsion colloid into skeleton gel agent to form skeleton slurry, painting, drying to form film, coating the film with pressure sensitive glue layer and protective polyurethane layer to form coiled preparation, and cutting in a cutter to form plaster. Using cheap dopamine precursor tyrosine or phenylalanine, rather than dopamine, can overcome the shielding of blood brain barrier on dopamine, and the addition of vitamin E can reduce the harm of smoking and remit smoking stopping syndrome. The present invention can reduce the toxicity of nicotine in low cost.

Description

technical field [0001] The invention relates to a medical preparation for smokers, in particular to a compound tobacco control patch and a preparation method thereof. Background technique [0002] It is well known that smoking is harmful to health, but it is difficult for people who have the habit of smoking to quit. There are many ways to quit smoking. Chinese patent 1173329 discloses a "health care cigarette patch and its preparation method". . Safer and more effective than patches made solely from natural tobacco extracts or synthetic nicotine. [0003] The "smoking cessation patch and its preparation method" disclosed in Chinese patent 1197655 is composed of a strip adhesive plaster, a drug core and a protective film. The main components of the drug core are clove, frankincense, myrrh, blood stew, wuyu, aconite, dried ginger, borneol and vaseline, etc., and are made of osmotic medicine and blending agent. [0004] The "compound transdermal absorption smoking cessatio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A24B15/10A61K9/72A61M37/00A61P25/34
Inventor 李健民高惠明杨吉田郝彬
Owner TIANJIN ZHAOSHI SCI & TECH DEV
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