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Process for preparing salicin

A preparation process, the technology of salicin, which is applied in the field of preparation process of salicin, can solve the problems of unseen extraction process, etc., and achieve the effects of high yield, good reproducibility, and high product yield

Inactive Publication Date: 2005-05-04
XIAN HAO TIAN BIO ENG TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main ingredient with medicinal effects is salicin contained in white willow, small-leaved willow, and weeping willow. There have been reports on the chemical and pharmacological studies of salicin, but so far there has been no report on the extraction process.

Method used

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  • Process for preparing salicin

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Effect test

Embodiment 1

[0022] Embodiment 1, the present invention comprises the following steps successively:

[0023] 1. Crush: Crush 50 kg of white willow branches and leaves into 1-2 cm small pieces of raw material. If the raw material is too large, the extraction will not be thorough, and if the raw material is too small, the residue will be difficult to remove;

[0024] 2. Hydrolysis and extraction: Add 2.5 kg of calcium oxide and 15 kg of water into the raw materials and mix well, put them into the extraction tank, and hydrolyze for 3.5 hours to hydrolyze the salicin derivatives in the raw materials; then add 80% 200 kilograms of ethanol, reflux extraction 80 minutes and filter, residue extracts 2 times again similarly, merges filtrate; Extract is carried out vacuum concentration, temperature is controlled below 80 ℃, concentrates filtrate to obtain extractum (being semi-finished product) 30 kilograms, specific gravity is 1.1;

[0025] 4. Refining steps: (1) Extraction, dissolve the extract wi...

Embodiment 2

[0026] Embodiment 2, the present invention comprises the following steps successively:

[0027] 1. Crush: Crush 50 kg of white willow branches and leaves into small pieces of 1-2 cm;

[0028] 2. Hydrolysis and extraction: add 1.5 kg of sodium hydroxide and 10 kg of water into the raw materials and mix well, put them into the extraction tank, and hydrolyze for 1.5 hours; add 200 kg of 80% ethanol to the extraction tank, reflux extraction for 40 minutes and filter, The residue was also extracted 3 times again, and the filtrate was combined; the extract was concentrated in vacuum, the temperature was controlled below 80°C, and the concentrated filtrate obtained 32 kg of extract, with a specific gravity of 1.2;

[0029] 4. Refining steps: (1) Extraction, dissolve the extract with 15 kg of water, add 20 kg of ethyl acetate for extraction, separate the extract and water phase, then repeatedly add 20 kg of ethyl acetate for extraction in the water phase, Repeat the extraction 2 time...

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Abstract

The invention relates to a kind of salicin and its manufacturing technology, which belongs to biology extraction field. The technology solution of the invention includes the steps in turn as follows: 1) Stock preparation: shatter with leaf into carven stock; 2) Hydrolysis and extraction: add basic matter into raw material for hydrolysis, and then extract with extraction agent in order to remove residue; 3) Concentration: get the semi-manufactured product containing salicin extractive material. The advantages of this industrial art can be described as follows: 1. acquirable raw material; 2. forthright industrial art; 3. high yield: the yield of the product is high, and according to production verification, the purity of salicin with refining step can achieve up to more than or equal to 99%; 4. low cost: the production of 1 kilogram with 95%n purity only sales a little more than upsi 3000.

Description

Technical field: [0001] The invention relates to the field of biological extraction, in particular to a preparation process of salicin. Background technique: [0002] There are about 500 species of Salix (Salix) in the family Salicaceae distributed all over the world, and they are mainly distributed in the temperate regions of the northern hemisphere. There are about 200 species in my country, among which white willow (Salix alba L), weeping willow (Salix babylonica Linn.), black willow (Salix cheilophila Schneid), and small leaf willow (Salix hypoleuea Seem) are used as medicine, with the functions of clearing heat and detoxification, expelling wind and dampness , promoting blood circulation and removing blood stasis and other effects. The main ingredient with medicinal effects is salicin contained in white willow, willow lobularis, and weeping willow. There have been reports on the chemical and pharmacological studies of salicin, but so far there has been no report on the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07G3/00C07H1/08C07H15/203
Inventor 王伟利
Owner XIAN HAO TIAN BIO ENG TECH
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