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Cepharanthine dripping pill and preparing process

A technology of fenugreek and preparation technology, which is applied in the directions of pill delivery, medical preparations containing active ingredients, organic active ingredients, etc. Effects with few side effects

Inactive Publication Date: 2005-05-18
彭红
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no oral dripping pill made of stephadin, and its effect has not been brought into full play.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Prescription: stephadin 10.0g

[0017] Glycerin Gelatin 5.0g

[0018] Glyceryl monostearate 2.0g

[0019] Poloxamer 0.5g

[0020] Polyethylene glycol 6000 10.0g

[0021] Made into 1000 capsules, each capsule contains 10.0mg of stephadin on average

[0022] Add 10.0 g of patinol to 10.0 g of polyethylene glycol 6000, 5.0 g of glycerin gelatin, 2.0 g of glycerol monostearate, and 0.5 g of poloxamer. , drop into the simethicone oil condensation at a rate of 40 drops per minute, take it out after forming, remove the condensing agent, check the amount of ingredients, pass the test, pack it, and get the finished product. Every 1000 cephadines drop pills contain 10.0g of cephalosin.

[0023] The inspection method is: this product is in the form of slightly yellow dripping pills with a bitter taste. The content determination method is high-performance liquid chromatography, using octadecylsilane bonded silica gel as a filler, using methanol-water-t...

Embodiment 2

[0025] Prescription: stephadin 5.0g

[0026] Macrogol 4000 15.0g

[0027] Polyethylene glycol 6000 5.0g

[0028] Made into 1000 capsules, with an average of 5.0mg of dry aureus in each capsule

[0029] Add 5.0g of Stephaniacine plus 5.0g of polyethylene glycol 6000, 15.0g of polyethylene glycol 4000, heat, melt and mix well, then drop into liquid paraffin condensate oil at a rate of 50 drops per minute at 80°C-95°C In the process, after forming, take it out, remove the condensing agent, check the amount of ingredients, pass the test, pack it, and get the finished product. Every 1,000 cephagnathin dripping pills contains 5.0g of cephalophyllin.

[0030] The inspection method is: this product is in the form of slightly yellow dripping pills with a bitter taste. The content determination method is high-performance liquid chromatography, using octadecylsilane bonded silica gel as a filler, using methanol-water-triethylamine (85:15:0.05) as a mobile phase; the detec...

Embodiment 3

[0032] Prescription: stephadin 2.g

[0033] Polyoxyethylene monostearate 10.0g

[0034] Macrogol 4000 130g

[0035] Made into 1000 capsules, each capsule contains 2.0mg of stephadin on average

[0036] Add 2.0g of patinol to 13.0g of polyethylene glycol 4000 and 10.0g of polyoxyethylene monostearate, heat, melt and mix well, then drop in at a rate of 20 drops per minute at 75°C-100°C In the condensed oil of vegetable oil, after forming, take it out, remove the condensing agent, check the amount of ingredients, pass it, pack it, and get the finished product. Every 1,000 cephagnathin dripping pills contains 2.0g of cephalophyllin.

[0037] The inspection method is: this product is in the form of slightly yellow dripping pills with a bitter taste. The content determination method is high-performance liquid chromatography, using octadecylsilane bonded silica gel as a filler, using methanol-water-triethylamine (85:15:0.05) as a mobile phase; the detection wavelength...

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Abstract

The cepharanthine dripping pill containing cepharanthine 1-10 mg and proper amount of dripping pill medium in each pill. The dripping pill medium is one or two of polyglycol-6000, polyglycol-4000, polyoxyethylene monostearate, sodium stearate, glycerin, gelatin, poloxamer, stearic acid, glycerin monostearate and insect wax. The preparation process of the cepharanthine dripping pill includes melting and mixing cepharanthine and dripping pill medium, dropping at 60-100 deg.c into condensating agent, and eliminating condensating agent. The condensating agent is one or two of dimethyl silicon oil, liquid paraffin, tea seed oil and rape seed oil. The cepharanthine dripping pill is white or slight yellow and bitter. The cepharanthine dripping pill is used in treating chemotherapy caused leucopenia, and has the features of less side effect, low dosage, high medicinal effect, etc.

Description

technical field [0001] The invention relates to an oral dripping pill, in particular to a stephadin dropping pill for clearing away heat and detoxification, which is used for leukopenia caused by chemotherapy in tumor patients and a preparation method thereof. Background technique [0002] Stephaniacine is a bisbenzylisoquinoline alkaloid, which is extracted and isolated from the medicinal plants of the genus Stephaniaceae. Dried aureus has the effects of anti-inflammatory, antibacterial, and immune regulation, and also has the functions of stimulating the reticuloendothelial system, activating hematopoietic tissue, and promoting the proliferation of bone marrow tissue. It is clinically used for the treatment of leukopenia, and for tumor patients with leukopenia caused by chemotherapy. [0003] Stephania Dropping Pills refers to a preparation made by heating, melting and mixing stepherin and related substrates, then dropping them into an immiscible condensing agent, shrinki...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/4745A61P35/00
Inventor 彭红许军
Owner 彭红
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