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Intravenous transfusion for treating infection of upper respiratory tract and its preparing method

A technology of intravenous infusion and preparation technology, which is applied to the treatment of upper respiratory tract infection and pneumonia, which can solve the problems of affecting the efficacy of medicines, ignoring wogonoside, and low content of active ingredients, so as to facilitate the preparation of modern preparations, improve the efficacy of medicines, and increase stability Effect

Active Publication Date: 2005-05-18
LUNAN HOPE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

They use the same conventional extraction and refining methods as other Yinhuang infusions: the extraction of honeysuckle takes chlorogenic acid as an index, while ignoring the effect of active ingredients such as isochlorogenic acid, and the content of chlorogenic acid is too low, a large number of impurities and ineffective ingredients have a negative effect on the drug. The safety and stability of Scutellaria baicalensis is a great threat; the extraction process of Scutellaria baicalensis is based on baicalin, and some have high purity but ignore the effect of active ingredients such as wogonin, which affects the curative effect of the drug
Conventional preparations use extracts as medicines, respectively using chlorogenic acid and baicalin as indicators, the content of active ingredients is low, and the ingredients in the extracts are not clear, leaving hidden dangers to the safety and stability of the drug

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0371] Chlorogenic acid 0.3g

[0372] Baicalin 1g

[0373] Sodium chloride 76g

[0374] Water for injection (add to) 10000ml

[0375] Weigh an appropriate amount of sodium hydroxide, add water for injection and stir to dissolve, put the amount of chlorogenic acid and baicalin into it, dissolve under stirring, use 1mol / L hydrochloric acid and 1mol / L sodium hydroxide to adjust the pH value of the medicinal solution, so that The pH value of the liquid medicine is in the range of 6.0-6.8. Add activated carbon with 1% liquid medicine amount, raise the temperature to 70°C, and stir for 30 minutes. Use a sand filter rod and a vacuum pump to filter the liquid medicine. Use 1mol / L sodium hydroxide to adjust the pH value of the liquid to 5.0. Add water to the full amount and filter the medicinal liquid with a filter, and measure the content and pH value of the semi-finished product according to the quality standard of the semi-finished product. Start potting and measure the fillin...

Embodiment 2

[0377] Chlorogenic Acid 25g

[0378] Baicalin 40g

[0379] Sodium chloride 5g

[0380]Water for injection (add to) 10000ml

[0381] Weigh 5g of sodium chloride, add water for injection and stir to dissolve, so that the concentration is 5%, put the amount of chlorogenic acid and baicalin into it, and stir to dissolve. Use 1mol / L hydrochloric acid and 1mol / L sodium hydroxide to adjust the pH value of the medicinal solution, so that the pH value of the medicinal solution is within the range of 6.0-6.8. Add activated carbon with 1% liquid medicine amount, raise the temperature to 70°C, and stir for 30 minutes. Use a sand filter rod and a vacuum pump to filter the liquid medicine. Use 1mol / L sodium hydroxide to adjust the pH value of the liquid to 8.0. Add water to the full amount and use a filter to filter the liquid medicine, and measure the content and pH value of the semi-finished product according to the quality standard of the semi-finished product. Start potting and me...

Embodiment 3

[0383] Chlorogenic acid 0.3g

[0384] Baicalin 40g

[0385] Sodium chloride 10g

[0386] Water for injection (add to) 10000ml

[0387] Weigh 10g of sodium chloride, add water for injection and stir to dissolve, so that the concentration is 10%, put the amount of chlorogenic acid and baicalin into it, and stir to dissolve. Use 1mol / L hydrochloric acid and 1mol / L sodium hydroxide to adjust the pH value of the medicinal solution, so that the pH value of the medicinal solution is within the range of 6.0-6.8. Add activated carbon with 1% liquid medicine amount, raise the temperature to 70°C, and stir for 30 minutes. Add water to the full amount and use a sand filter stick and a vacuum pump to filter the medicinal solution. Use 1mol / L sodium hydroxide to adjust the pH value of the liquid to 7.0. Use a filter to filter the liquid medicine, and measure the content and pH value of the semi-finished product according to the quality standard of the semi-finished product. Start pott...

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PUM

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Abstract

The present invention discloses a kind of intravenous transfusion liquid and its preparation process. The intravenous transfusion liquid consists of chlorogenic acid 0.03-2.5 mg / ml, baicalin 0.1-4.0 mg / ml, isoosmotic regulator 5-10 mg / ml and pH regulator to regulate pH value to 4-9. It contains no forsythin and jasminoidin. The medicine has obvious curative effect on upper respiratory tract infection, pneumonia and viral respiratory tract infection.

Description

technical field [0001] The invention relates to an infusion solution for treating upper respiratory infection and pneumonia and resisting upper respiratory virus. Specifically, it is an injection prepared from Chinese herbal medicine, and also relates to a preparation method of the medicine. Background technique [0002] In my country, upper respiratory tract infections such as pharyngitis and tracheitis, pneumonia and respiratory virus infection are common and frequently-occurring diseases. Not only itself often protracted, but also can cause a variety of complications, endangering human health. With the development of industrial society, the air is polluted to varying degrees, which increases the incidence of upper respiratory tract infections and pneumonia-like diseases such as rhinitis and pharyngitis. Modern medicine believes that although the main pathogenic bacteria of this disease are streptococci, mixed infections of bacteria and viruses are not uncommon, and the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P11/00G01N30/02G01N33/15
Inventor 赵志全
Owner LUNAN HOPE PHARM CO LTD
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