Ganoderma lucidum polysaccharide protein and its preparing method and use

A technology of Ganoderma lucidum polysaccharide and polysaccharide protein, which is applied in the field of Ganoderma lucidum polysaccharide protein and its preparation, and can solve problems such as poor practicability, inability to carry out industrial production, and different polysaccharide structures and molecular weights.

Inactive Publication Date: 2005-06-22
福州绿谷生物药业技术研究所(普通合伙) +5
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In summary, the prior art methods for extracting Ganoderma lucidum polysaccharides include hot water extraction (or water decoction), ethanol extraction and dilute alkali extraction. Industrialized production, so the practicability is poor, and the structure and molecular weight of the obtained polysaccharide are also different, especially the small molecular weight of the polysaccharide peptide directly affects the medicinal value of the polysaccharide protein of Ganoderma lucidum

Method used

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  • Ganoderma lucidum polysaccharide protein and its preparing method and use
  • Ganoderma lucidum polysaccharide protein and its preparing method and use
  • Ganoderma lucidum polysaccharide protein and its preparing method and use

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Embodiment 1

[0078] The preparation method of Ganoderma lucidum polysaccharide protein G1-PP:

[0079] 1. Select grass-planted Ganoderma lucidum, clean the dried fruiting body of Ganoderma lucidum, dry it, and use a coarse particle crusher to crush it into tobacco-like substances of about 20 mesh.

[0080] 2. Weigh 300 grams of pulverized shredded tobacco ganoderma, reflux with 3000-4000 ml of 95% ethanol for 3 hours, recover ethanol, and dry ganoderma filaments. Using the ratio of ganoderma lucidum filaments: hot water = 1:15, the ganoderma lucidum filaments were subjected to hot water reflux extraction for 3 times for 2.5 hours, 2 hours, and 1 hour respectively, and the filtered water extracts were combined.

[0081] 3. Concentrate the water extract to one-tenth of the original volume at a temperature of 90°C, and then use a centrifuge with a speed of 3000r / min for 15min to perform centrifugation, and concentrate the supernatant to an amount equivalent to 1 gram of ganoderma lucidum is ...

Embodiment 2

[0087] The preparation method of Ganoderma lucidum polysaccharide protein,

[0088] 1. Provide a fruiting body of Ganoderma lucidum as a raw material matrix, clean the dry fruiting body of Ganoderma lucidum, dry it, and crush it into a shredded tobacco substance of about 20 meshes with a coarse particle crusher.

[0089] 2. Weigh 300 grams of pulverized shredded tobacco ganoderma, reflux with 3000-4000 ml of 95% ethanol for 3 hours, reclaim the ethanol, and dry the ganoderma lucidum alcohol to obtain a dried product.

[0090]3. Extract the dry matter with water, the ratio is dry matter: water = 1:15, extract twice, the first extraction time is 2.5 hours, the second extraction time is 1.5 hours, and the two extracts are combined.

[0091] 4. Stand and filter the extract, obtain the filtrate and concentrate until the concentrated solution contains crude drug: water = 1:5 or so as a crude concentrated solution. The concentration equipment is a rotary evaporator whose rotation spe...

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Abstract

The invention relates to a peptide containing 5-20 amino acids, in particular a glossy ganoderma polysaccharide protein G1-PP which is prepared by using glossy ganoderma as raw material precursor for extraction, condensing the extraction liquid, carrying out ultrafiltration or dialysis to keep the polysaccharide protein with high molecular weight. The invention also provides a process for industrial production of glossy ganoderma polysaccharide protein and the use of glossy ganoderma polysaccharide protein G1-PP in preparing medicament with antineoplastic action.

Description

technical field [0001] The invention relates to a peptide containing 5 to 20 amino acids, in particular to a ganoderma polysaccharide protein extracted from ganoderma lucidum and its preparation method and application. Background technique [0002] Ganoderma lucidum has special medicinal value and is regarded as a precious Chinese herbal medicine. The traditional way of taking it is decoction or cooking. At present, many scholars in China are working on the extraction, separation and medicinal analysis of the active components of Ganoderma lucidum. Among them, the research on polysaccharides of Ganoderma lucidum mainly includes the following examples: [0003] 1. The journal "Chinese Herbal Medicine" 1994, 25(8).-395-397 recorded the "Chemical Research on Ganoderma lucidum peptidoglycan" written by the authors He Yunqing and Li Rongzhi, which extracted the glucan peptide from the fruiting body of Ganoderma lucidum The molecular weights are relatively small, generally tens o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/16A61P35/00C07K14/37
Inventor 林志彬林树钱王赛贞吕松涛曹琦珍
Owner 福州绿谷生物药业技术研究所(普通合伙)
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