Curcuma zedoary oil controlled release elution rack for preventing and curing re-stenosis in coronary artery rack
A technology for eluting stents and zedoary oil, which is applied in stents, surgery, devices with human tubular structures, etc., to achieve the effects of inhibiting cell growth, inducing cell apoptosis, and increasing the number of apoptotic cells
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0014] Preparation of zedoary oil controlled release elution stent
[0015] A stainless steel stent is used, and a polybutylmethacrylate / nano-silicon dioxide composite material is used as a drug-controlled release coating. First prepare 1% tetrahydrofuran solution of polybutyl methacrylate, which contains nano-silica of 25-30% polymer amount, and adds the zedoary oil medicine to the solution so that the weight ratio of medicine to polybutyl methacrylate Stir to suspend the drug in the solution, spray the suspension evenly on the stent with a spray gun, dry at 40°C, weigh accurately, and calculate the drug content per square millimeter of the stent surface. The thickness of the coating is 12-30 μm, and the drug content on the surface of the stent is 1.8-3.6 μg / mm 2 . Install the drug-eluting stent on the balloon and sterilize it with ethylene oxide for use.
[0016] The in vitro controlled release test of the zedoary oil controlled-release elution stent showed that the drug ...
Embodiment 2
[0018] Animal experiments were conducted to test the effect of zedoary oil controlled-release eluting stent on intimal hyperplasia after stenting in experimental animals, and to evaluate the safety and efficacy of zedoary oil controlled-release eluting stent in preventing restenosis after stenting.
[0019] Healthy hybrid adult dogs were randomly divided into 2 groups: according to the ratio of stent diameter and coronary artery diameter of 1.2 to 1.3:1, the simple coating stent and the curcuma oil controlled-release eluting stent of Example 1, the coating thickness of which was 12 μm, and the stent Surface drug content 1.8μg / mm 2 Appropriate blood vessel segments of the circumflex and anterior descending branches were randomly implanted into the coating group and the zedoary oil group, with 10 rats in each group. They began to take aspirin 250 mg one day before the operation, and were killed until 30 days later. The heart, liver, spleen, lung, kidney, stomach, brain, skeletal...
Embodiment 3
[0033] Healthy hybrid adult dogs were randomly divided into two groups: according to the ratio of stent diameter and coronary artery diameter of 1.2 to 1.3:1, the simple coating stent and the zedoary oil controlled-release elution stent of Example 1, the coating thickness of which was 30 μm, and the stent Surface drug content 3.6μg / mm 2 Randomly implant suitable blood vessel segments of the circumflex branch and anterior descending branch, namely coating group and zedoary oil group, 10 rats in each group, start taking aspirin 250mg 1 day before the operation, and kill them until 30 days, take the stent implanted into the blood vessel, The heart, liver, spleen, lung, kidney, stomach, brain, skeletal muscle, testis and other vital organs of two animals were taken and fixed.
[0034] Optical microscope and scanning electron microscope were used to observe the histopathological changes of stented vessel segments and important organs in each group. Computer images were used to qua...
PUM
Property | Measurement | Unit |
---|---|---|
Thickness | aaaaa | aaaaa |
Coating thickness | aaaaa | aaaaa |
Thickness | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com