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Prepn and application of heparin silver

A kind of technology of heparin and heparin salt, applied in medical field

Inactive Publication Date: 2005-09-28
凌沛学
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preparation method and application of heparin silver salt, and the preparation of heparin silver for the treatment of burns and scalds have not yet been reported publicly.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] With 0.3 kilograms of heparin sodium [average molecular weight is less than 60~70% by weight of 8000Da, according to the method that China Food and Drug Administration Trial Standard WS-487 (X-423)-2001 stipulates, measure anticoagulant (FIIa) effect according to sheep plasma method The anti-FXa titer was determined according to the COATEST kit method, and the anti-FXa activity was 2.3 times that of the anti-FIIa activity. ] was dissolved in 10 liters of deionized water, and the following steps were performed under dark conditions: add 1.2 kg of silver nitrate, stir and react at room temperature for 2 hours, concentrate under reduced pressure at 35°C to 40°C until the volume of the reaction solution is about 3 liters, and use 0.8 micron The reaction solution is filtered through a microporous membrane, and the filtrate is reserved for recovery. The precipitate is dissolved in 0.3 liters of deionized water, stirred and dissolved, dialyzed with a dialysis membrane with a mo...

Embodiment 2

[0020] Dissolve 0.3 kg of heparin sodium (average molecular weight 12,000 to 15,000 Da, determined according to the heparin bioassay method in Appendix XIID of the Chinese Pharmacopoeia 2000 edition, the potency is 156 units / mg). Operation under conditions: add 1.1 kg of silver nitrate, stir at room temperature for 2 hours, concentrate under reduced pressure at 35°C to 40°C to a volume of about 3 liters of the reaction solution, filter the reaction solution with a 0.8 micron microporous membrane, and keep the filtrate for recovery. Dissolve the precipitate in 0.5 liters of deionized water, stir to dissolve, and use an ultrafiltration membrane with a molecular weight cutoff of 2000 for ultrafiltration. When the volume of the solution is reduced to 0.4 liters during the ultrafiltration process, add 0.1 liters of deionized water, and add 3 times. Ultrafiltration to a solution volume of about 0.3 liters, then concentration under reduced pressure to a solution volume of about 0.2 li...

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PUM

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Abstract

The present invention relates to the preparation process of heparin silver and the preparation of heparin silver medicine for treating burns and scalds. The preparation process of heparin silver includes the steps of ion displacement of soluble heparin salt with silver nitrate in water solution, concentration, filtering, purification, drying, etc. and the product has silver ion content of 25-45 %, sodium ion content less than 0.5 %, and nitrate radical content less than 100 ppm. The medicine prepared with heparin silver, animal test shows, may be used in treating burns and scalds to speed the wound heal and reduce scar.

Description

Technical field: [0001] The invention belongs to the field of medical technology, and relates to a preparation method of heparin silver salt and a medicine for treating burns and scalds prepared by using heparin silver. Background technique: [0002] Heparin is derived from animal tissue and is a kind of sulfated glycosaminoglycan with a complex structure. Its basic skeleton is a polysaccharide chain composed of repeating disaccharide units connected by uronic acid and glucosamine with glycosidic bonds. For duronic acid and glucuronic acid, the sulfation and acetylation of each monosaccharide residue is more varied, including N-sulfate group, N-acetyl group and O-sulfate group (ester) in different positions. Unfractionated heparin has a molecular weight of 3,000 to 30,000 Daltons, an average molecular weight of 12,000 to 15,000 Daltons, and products with a molecular weight of 3,000 to 8,000 Daltons are called low molecular weight heparins. Anticoagulant and antithrombotic a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/727A61P17/02C08B37/00C08B37/10
CPCA61K31/727A61K9/14A61K33/38C08B37/0075A61P17/02
Inventor 凌沛学贺艳丽陈建英汪敏庞晓阳王雷
Owner 凌沛学
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