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Compound insulin energy mistura preparation and use thereof

An insulin and preparation technology, applied in the field of medicine, can solve the problems of unstable insulin and unsuitable preparation, etc.

Inactive Publication Date: 2005-10-12
FUKANGREN BIO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, insulin is also unstable when it is cold, so it is not suitable for preparation into freeze-dried powder dosage form

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Embodiment 1: Preparation of compound insulin injection for adults

[0040] Prescription: Inosine 40g

[0041] ATP 4g

[0042]Vitamin C 100g

[0043] Insulin 0.77g (equivalent to 20000U)

[0044] Glycine 15g

[0045] m-cresol 2.2g

[0046] Add water for injection to 1000ml

[0047] Preparation method: Weigh the prescribed amount of inosine, ATP, vitamin C, insulin, glycine, m-cresol, add appropriate amount of distilled water, stir to dissolve, adjust the pH to 8.0, add medicinal activated carbon, and absorb at 40°C for about 20 minutes , decarbonize, filter with a 0.22μm microporous filter membrane, add water to the filter to the full amount, pack 5ml, 10ml / branch into volumetric flasks, and obtain.

Embodiment 2

[0048] Embodiment 2: Preparation of compound insulin injection for adults

[0049] Prescription: Inosine 40g

[0050] ATP 4g

[0051] Vitamin C 100g

[0052] Insulin 0.77g (equivalent to 20000U)

[0053] Ornithine 40g

[0054] m-cresol 2.5g

[0055] Add water for injection to 1000ml

[0056] Preparation method: Weigh the prescribed amount of inosine, ATP, vitamin C, insulin, ornithine, and m-cresol, add appropriate amount of distilled water, stir to dissolve, adjust the pH to 8.0, add medicinal activated carbon, and adsorb about After 20 minutes, decarbonize, filter with a 0.22 μm microporous membrane, add water to the filter to the full amount, and pack 5ml and 10ml / bottle into volumetric flasks to obtain the product.

Embodiment 3

[0057] Embodiment 3: Preparation of compound insulin injection for adults

[0058] Prescription: Inosine 40g

[0059] ATP 4g

[0060] Vitamin C 100g

[0061] Insulin 0.77g (equivalent to 20000U)

[0062] Glycine 30g

[0063] Paraben 2g

[0064] Add water for injection to 1000ml

[0065] Preparation method: Weigh the prescribed amount of inosine, ATP, vitamin C, insulin, glycine, and paraben, add appropriate amount of distilled water, stir to dissolve, adjust the pH to 8.0, add medicinal activated carbon, and absorb about 20 at 40°C. Minutes, decarbonize, filter with a 0.22μm microporous membrane, add water to the filter to the full amount, pack 5ml, 10ml / branch into volumetric flasks, and get ready.

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PUM

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Abstract

A high-energy compound insulin mixture in the form of injection for treating diabetes is prepared proportionally from inosine, adenosine triphosphate, VC, insulin and medicinal additive.

Description

Technical field: [0001] The invention relates to the field of medicine, in particular to a compound insulin injection and a preparation method thereof, which can be widely used in the treatment of various types of diabetes. The compound pharmaceutical preparation of the present invention contains 10-1000 mg of inosine, 1-100 mg of adenosine triphosphate, 10-1000 mg of vitamin C, 25-1000 U of insulin and appropriate amount of pharmaceutically acceptable auxiliary materials in the preparation of a unit dose. Background technique: [0002] Insulin is an amorphous white or near-white powder, sometimes crystalline, easily soluble in dilute acid and dilute alkali, almost insoluble in ether and chloroform, slightly soluble in water. Its solution is a light yellow clear liquid, easily destroyed by heat, but it cannot be frozen. [0003] Insulin can promote the uptake and utilization of glucose by tissues, increase glycogen synthesis and inhibit glycogen dissimilation, thereby lower...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K9/14A61K9/19A61K38/28A61P3/10
Inventor 鄂滟严轶东
Owner FUKANGREN BIO PHARMA
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