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Preparation technology of low solubility residual water setose thistle extract and its preparation technology

A preparation process, the technology of milk thistle, applied in the field of preparation of milk thistle extract with low solvent residue, can solve the problems of poor color, solvent residue, long production cycle, etc., and achieve high product yield, low solvent residue, Excellent product quality

Inactive Publication Date: 2005-10-26
陕西赛德高科生物股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] ①Volatile, easy to catch fire, unsafe
[0016] ③Petroleum ether residue is too high
[0017] 2. Use ethanol as the extraction solvent, heat and stir with water, sodium bicarbonate, and water in order to degrease. The product quality is poor, the color is not good, and the degreasing is not clean, which brings difficulties to drying and easily causes microbial contamination.
Moreover, the extraction with ethanol is incomplete, the production cycle is long, and the cost is high
[0018] 3. Use CO first 2 Supercritical extraction, the degreased solids are then extracted with organic solvents. This method has the following disadvantages:
[0019] ①The number of times of supercritical extraction increases, the production cycle is lengthened, and the production cost is greatly increased
[0020] ② Extraction and then extraction with organic solvents, the problem of solvent residues has not been resolved

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1: take by weighing 100kg milk thistle seed, extract oil by oil press, the oil yield is about 17% of the seed weight before oil extraction, and the oil cake after oil extraction is pulverized into coarse powder, directly packs in the Soxhlet extraction tank, Add 300kg of ethanol, extract for 8 hours by the Soxhlet extraction method (with reference to "Food Analysis" China Light Industry Press, 1998) at 40°C-50°C, release the paste, and then add it to the residue in the Soxhlet extraction tank Add 300kg of ethanol, continue Soxhlet extraction for 12 hours, release the paste, combine the two pastes, let it stand for 4 hours to precipitate, pour out the upper oil layer and water layer, and remove the precipitate with CO 2 Supercritical extraction degreases, and removes organic solvent residues such as petroleum ether, acetone and ethanol; the extraction temperature is 45°C, the pressure is 25Mpa, the separation pressure is 5Mpa, and the separation temperature is ...

Embodiment 2

[0030] Embodiment 2: the difference between this embodiment and embodiment 1 is that ethanol is changed into acetone, and others are all the same as embodiment 1, and total flavonoids of milk thistle can be obtained equally.

[0031] Compared with the prior art, the present invention has the following advantages:

[0032] 1. The subsequent deoiling process is simplified, and flammable and explosive petroleum ether degreasing is no longer used, which increases the safety and environmental protection requirements of production.

[0033] 2. Using CO 2 Supercritical extraction and degreasing removes residues of petroleum ether and reduces residues of organic solvents such as acetone or ethanol.

[0034] 3. Make the product degreasing and degreasing safer, the product color is good, the quality is excellent, and the product quality meets the requirements of international and domestic quality standards.

[0035] 4. If 50kg of milk thistle extract is used to degrease with petroleum...

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Abstract

A process for preparing the high-solubility general flavone of milk thistle from its seeds includes such steps as squeezing oil to obtain cake, pulverizing, extracting in ethanol or acetone twice, collecting extract, depositing, supercritical CO2 extracting of deposit, and baking.

Description

technical field [0001] The invention relates to a method for extracting plant beneficial components, in particular to a preparation process of milk thistle extract with low solvent residue. Background technique [0002] Total flavonoids of milk thistle are flavonoid lignans extracted from the fruit of Silybum marianum (L.) Gaerth [Carduus marianus L.], a plant of the genus Silybum in the family Asteraceae. There are many biological activities, especially in the anti-hepatotoxicity and the promotion of liver cell regeneration, which has a strong pharmacological effect and has been used in clinical applications, mainly for the treatment of hepatitis, cirrhosis and various types of liver damage. Therefore, many researchers have proposed a method for extracting total flavonoids from milk thistle seeds. Through the data retrieval that the inventor carries out, the references relevant to the present invention are as follows: [0003] [1]. Acetone method ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
Inventor 杨建文汤文王进旗刘阳林唐卫霞杨彬彬崔静海
Owner 陕西赛德高科生物股份有限公司
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