Unlock instant, AI-driven research and patent intelligence for your innovation.
Pyrazole derivative, medicinal composition containing the same, medicinal use thereof, and intermediate for production thereof
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A technology of pyrazole derivatives and alkyl, applied in the field of pyrazole derivatives, can solve the problems of insufficient absorption of glucose and galactose
Inactive Publication Date: 2005-10-26
KISSEI PHARMA
View PDF15 Cites 8 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
Glucose and galactose underabsorption have also been reported in patients with dysfunction due to congenital abnormalities of human SGLT1 (see 6-8 below)
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
[0309] The title compound was prepared analogously to Example 1, using ammoniumchloride instead of glycinamide hydrochloride.
[0310] 1 H-NMR (CD 3 OD)δppm:
[0311] 1.05-1.2(6H, m), 1.8-1.95(2H, m), 2.19(2H, t, J=7.6Hz), 2.58(2H, t, J=7.5Hz), 2.85-2.95(1H, m) , 3.3-3.45(4H, m), 3.6-3.8(3H, m), 3.8-3.9(1H, m), 5.0-5.1(1H, m), 7.0-7.15(4H, m)
[0314] The title compound was prepared analogously to Example 1, substituting 3-aminopropanamide for glycinamide hydrochloride.
[0315] 1 H-NMR (CD 3 OD)δppm:
[0316] 1.05-1.2(6H, m), 1.8-1.95(2H, m), 2.15(2H, t, J=7.3Hz), 2.4(2H, t, J=6.7Hz), 2.56(2H, t, J= 7.5Hz), 2.85-2.95(1H, m), 3.25-3.45(6H, m), 3.6-3.9(4H, m), 5.0-5.1(1H, m), 7.0-7.15(4H, m)
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
PUM
Login to View More
Abstract
The present invention provides a pyrromonazole derivant shown in the formula (I). In the formula (I), R<1> is H, optional substituent C1-6 alkyl, etc.; one group in Q and T is a group represented by the formula (a) or a group represented by the formula (b), while another group is optional substituent C1-6 alkyl, etc.; X is a single bond, O or S; Y is a single bond, C1-6 alkylidene, etc.; R<3>, R<6> and R<7> are H, halogen atoms, etc.; the present invention also provides a pharmaceutically acceptable salt or a prodrug thereof. Showing excellent inhibitory activity for human SGLT1, the present invention can be used as drugs to prevent or treat hyperglycemia-related diseases (such as, diabetes, diabetic complications or obesity). The present invention also provides a drug compound of the derivants, a pharmic use thereof and an intermediate used for production.
Description
technical field [0001] The present invention relates to pyrazole derivatives which can be used as medicines, their pharmaceutically acceptable salts or their prodrugs, pharmaceutical compositions containing them, their pharmaceutical use and intermediates for their production. [0002] More specifically, the present invention relates to pyrazole derivatives having inhibitory activity in human SGLT1, pharmaceutically acceptable salts thereof or prodrugs thereof, which can be used as drugs to prevent or treat diseases related to hyperglycemia (such as diabetes, glucose intolerance disorder, fasting hyperglycemia disorder, diabetic complications or obesity), and also pharmaceutical compositions containing them, their pharmaceutical use and intermediates for their production. Background technique [0003] Diabetes is one of the lifestyle-related diseases, whose background is a change in eating habits and lack of exercise. Therefore, diet and exercise therapy are implemented in ...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to View More 
Login to View More