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Medicine composition with total tribuloside possessing effect similar to female bormone and its prepn process

A technology of total saponins of Tribulus terrestris and estrogen, applied to medical preparations containing active ingredients, pharmaceutical formulas, unknown raw materials, etc., can solve the problem of delaying women's menopause and anti-osteoporosis, without the estrogen-like effect of total saponins of Tribulus terrestris, There is no such problem as the prevention and treatment of total saponins of Tribulus terrestris

Inactive Publication Date: 2005-12-14
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] But so far there is no research report on the estrogen-like effect of total saponins of Tribulus terrestris, and there is no research and application of total saponins of Tribulus in the preparation of prevention and treatment of women's menopausal syndrome, delaying women's menopause and anti-osteoporosis and preventing and treating senile dementia.

Method used

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  • Medicine composition with total tribuloside possessing effect similar to female bormone and its prepn process
  • Medicine composition with total tribuloside possessing effect similar to female bormone and its prepn process
  • Medicine composition with total tribuloside possessing effect similar to female bormone and its prepn process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Example 1. Example of TS preparation method

[0057] 1. Preparation of TS by solvent extraction method / solvent extraction method

[0058] Tribulus terrestris fruit or ground dry product 1.5 kg, crushed, decocted in water (15L×3), combined the extracts, concentrated to 1.30, precipitated with 95% ethanol, filtered, concentrated ethanol, reduced pressure or spray-dried to obtain TS . Or after the water extract is concentrated, it is extracted with water-saturated n-butanol, concentrated under reduced pressure to recover n-butanol, and the solvent is recovered under reduced pressure to dryness to obtain TS with a yield of about 10%.

[0059] 2. Preparation of TS by solvent extraction / polyamide column chromatography

[0060] 1.5 kg of dried tribulus fruit or above-ground part, crushed, extracted with 70% ethanol (15L×3) under reflux, combined the extracts, and recovered the ethanol. The concentrated solution is eluted with water and 30% ethanol on a pretreated 2.5 kg polyamide ...

Embodiment 2

[0063] Example 2. New pharmacological activity experiment of TS

[0064] In order to prove that the TS of the present invention has an estrogen-like effect during the development process, it can be used to prevent and treat women's menopausal syndrome, delay women's menopause, prevent and treat osteoporosis and senile dementia in the following experimental studies:

[0065] 2.1 Medicines and kits:

[0066] 1. Tribulus Total Saponins (TS): Homemade

[0067] 2. Diestrol (JXCF): produced by Beijing Yimin Pharmaceutical Factory, batch number: 0101020

[0068] 3. Methyltestosterone tablets (JGT): produced by Zhenjiang Jibeier Pharmaceutical Co., Ltd., a Sino-foreign joint venture, batch number: 980202

[0069] 4. Gypenosides (JGL): Produced by Ankang Traditional Chinese Medicine Factory, Shanxi Province, China, batch number: 20001034

[0070] 5. Soda lime: Beipiao Nanshan Calcium Product Factory, batch number: 200050800

[0071] 6. Yan Gengdan (YGD): Produced by Shenyang Shengpeng Heal...

Embodiment 3

[0180] Example 3 Drug combination of TS

[0181] 1. Mix 1 g of TS and 50 g of starch with water to make soft material, pass through a 12-mesh sieve to granulate, and dry to obtain granules. In this granule, TS50 mg is contained in every 2.5 g. Combined with symptoms, 2.5 grams each time, 3 times a day.

[0182] 4. Mix 10 grams of TS with 36 grams of lactose and 4 grams of magnesium stearate, and fill the capsules with 60 mg. In this capsule, each capsule contains 15 mg of TS. Combine symptoms, 2-3 capsules each time, 3-4 times a day.

[0183] 5. Mix 10 grams of TS with 38 grams of microcrystalline cellulose and 5 grams of magnesium stearate. The mixture is beaten into tablets with a diameter of 6 mm and a weight of 200 mg using a single punch tablet machine. Each tablet in this tablet contains 15-20 mg of TS. Combined with symptoms, 3 tablets each time, 3-4 times a day.

[0184] 6. TS5g, add 100ml water to dissolve, add 4ml Danshensu, add single syrup to 1000ml to get syrup. This ...

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Abstract

The present invention relates to medicine composition with total tribuloside possessing effect similar to female hormone and its preparation and new application in preventing and treating female's climacteric syndrome, putting off female's climacteric period and treating osteoporosis and senile dementia. The medicine composition contains total tribuloside over 40 wt% and pharmaceutically acceptable carrier or excipient, and may also contain other auxiliary or synergistic component(s), natural or chemically synthetic. The present invention is used in preparing medicine or health food for preventing and treating female's climacteric syndrome, putting off female's climacteric period and treating osteoporosis and senile dementia.

Description

Technical field: [0001] The present invention relates to a pharmaceutical composition of Tribulus terrestris total saponins with estrogen-like effects and a preparation method thereof, in particular to the preparation of Tribulus terrestris total saponins for preventing and treating women's menopausal syndrome, delaying women's menopause and anti-osteoporosis, and preventing and treating senility New applications for dementia drugs. Background technique: [0002] Tribulus terrestris L is a traditional Chinese medicinal material, belonging to the genus Tribulus terrestris of the Tribulus family. It was first published in "Shen Nong's Materia Medica" and listed it as top grade. It has the effects of calming the liver and relieving depression, promoting blood circulation and dispelling wind, expelling phlegm and relieving cough, improving eyesight, diuresis and relieving itching. All medical books of the past dynasties listed Tribulus as top-grade medicine. The main active ingredien...

Claims

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Application Information

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Patent Type & Authority Applications(China)
Inventor 曹颖林窦德强周晓棉宋其玲
Owner SHENYANG PHARMA UNIVERSITY
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