Magnetic nano drug carrier, and its preparing method and use

A magnetic nano-carrier technology, applied in the direction of inorganic non-effective ingredients

Inactive Publication Date: 2005-12-21
GUANGDONG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the problem of not blocking blood vessels and facilitating cell absorption, but also achieving a large and sufficient drug adsorption capacity, it is an innovation to use nano-scale carbon-coated magnetic metal nanoparticles as drug carriers.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Weigh an appropriate proportion of pure Fe and pure graphite powder (containing 50% Fe) and mix it to make an anode composite rod, and use a pure graphite rod for the cathode, put the two electrodes into the reaction chamber, and use the DC carbon arc method to feed high-purity Ar Gas, the reaction voltage is 60V, the current is 100A, and the Ar pressure is 20kPa. Under arc discharge, dark black fluffy carbon-coated iron nanocrystals are obtained. The morphology and particle size of the carbon-coated iron nanoparticles are observed by a transmission electron microscope, and the outer diameter is 30-50 nm. Detect its heating effect in normal saline: take 50 grams of normal saline and 0.15 grams of carbon-coated iron nanoparticles with an iron content of 50% and mix them in a small beaker (the addition ratio of carbon-coated iron nanoparticles is 0.3%). On the induction coil of the 15kw electromagnetic inductor, the operating current of the electromagnetic inductor is 300...

Embodiment 2

[0014] Weigh an appropriate proportion of pure Fe and pure graphite powder (containing 70% Fe) and mix it to make an anode composite rod, and use a pure graphite rod for the cathode, put the two electrodes into the reaction chamber, and use the DC carbon arc method to feed high-purity Ar Gas, the reaction voltage is 55V, the current is 150A, and the Ar pressure is 30kPa. Under arc discharge, dark black fluffy carbon-coated iron nanocrystals are obtained. The morphology and particle size of the carbon-coated iron nanoparticles are observed by a transmission electron microscope, and the outer diameter is 50-80nm. Detect its heating effect in normal saline: take 50 grams of normal saline and 0.40 g of carbon-coated iron nanoparticles with an iron content of 70% and mix them in a small beaker (the addition ratio of carbon-coated iron nanoparticles is 0.8%). On the induction coil of the 15kw electromagnetic inductor, the operating current of the electromagnetic inductor is 600A, an...

Embodiment 3

[0016] Weigh an appropriate proportion of pure Fe and pure graphite powder (containing 50% Fe) and mix it to make an anode composite rod, and use a pure graphite rod for the cathode, put the two electrodes into the reaction chamber, and use the DC carbon arc method to feed high-purity Ar Gas, the reaction voltage is 55V, the current is 200A, and the Ar pressure is 50kPa. Under arc discharge, dark black fluffy carbon-coated iron nanocrystals are obtained. The morphology and particle size of the carbon-coated iron nanoparticles are observed by a transmission electron microscope, and the outer diameter is 30-50 nm. Detect its heating effect in pig liver: take by weighing 50 grams of broken fresh pig liver and 0.45 gram of carbon-coated iron nanoparticles with 50% iron content and mix them in a small beaker (the addition ratio of carbon-coated iron nanoparticles is 0.9% ), placed on the induction coil of a 15kw electromagnetic inductor, the operating current of the electromagnetic...

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Abstract

The present invention discloses a magnetic nano medicine carrier, its preparation method and application of said carrier. Said magnetic nano medicine carrier is nano iron and nano carbon compound, in which the carbon is 20-80% and iron is 80-20%. The carrier appearance observed in the TEM is that the iron nano particles are covered with nano-grade carbon covering layer, the outside diameter distribution of carbon covering layer is 20-100nm and the outside diameter distribution of iron nano particles is 2-50nm. The said magnetic nano medicine carrier is placed in high-frequency alternating magnetic field, the electric current 300-600A of alternating magnetic field is produced so as to make it produce heating effect.

Description

technical field [0001] The invention relates to a magnetic nano medicine carrier, a preparation method thereof and an application of the carrier. Background technique [0002] Since the development of the magnetic carrier system in the late 1970s, there have been many kinds: magnetic albumin microspheres, ferrofluids, magnetic liposomes, etc. The magnetic carrier used in animal experiments in the early days is mainly magnetic albumin microspheres, which have a high drug carrying rate, simple synthesis, and are easy to store. However, experiments have proved that their magnetic induction intensity is not enough, and their accumulation in tumor lesions is not good. Cause vascular embolism, and then gradually eliminated or improved. Germany uses ferrofluid (particle size 100nm) as the carrier of epirubicin, which is injected into the body through intravenous injection, and a constant magnetic field is provided outside the skin of the tumor site to position the ferrofluid at th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/02
Inventor 张海燕何艳阳周纯陈易明
Owner GUANGDONG UNIV OF TECH
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