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Biological dressing and its preparing method

Inactive Publication Date: 2006-02-22
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the dressing is not spongy, so there are deficiencies in softness, breathability, and fluid drainage
The Chinese patent application with the application number 00102103.6 mentions that the use of porous silk fibroin material can improve the softness and the function of removing fluid accumulation, but it needs to add other compounds, and there is no reinforcement layer, which will affect the silk fibroin biological dressing to play its natural biological phase. Capacitance and healing effect, and insufficient strength
At present, in the prior art, there is no film covering the surface of biological dressings to facilitate the regulation of wound humidity

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Add 5% solution volume percentage of solidification catalyst ethylene glycol diglycidyl ether to the 6% mass fraction of silk fibroin aqueous solution, stir and mix uniformly, add a thin layer of the mixed solution to the mold, at a temperature of -50~-2℃ Under freeze. In this embodiment, freezing at a temperature of -20°C for 3 hours is used. Take out the mold and add distilled water to the mold. The thawed material is soaked in distilled water for 3 days, and the water is changed several times a day to remove the solidification catalyst and free silk fibroin. After draining the water to a certain water content, it is disinfected and packaged.

[0025] The biological dressing manufactured in this embodiment is composed of a single porous silk fibroin sponge material. Due to the limited tensile breaking strength, this product is mainly suitable for the treatment of small-area wounds.

[0026] The internal average pore diameter of the biological dressing manufactured in this...

Embodiment 2

[0028] Add 3% solution volume percentage of curing catalyst polypropylene glycol diglycidyl ether to the 4% silk fibroin aqueous solution. Spread a polyamide mesh reinforcement layer on the bottom of the mold, add a thin layer of the solution to the mold, and freeze at a temperature of -50 to -2°C. In this embodiment, freezing at a temperature of -30°C for 2 hours is used. Take out the mold and thaw it at natural temperature to loosen the added material and mold. You can also continue to add distilled water, submerge the material with distilled water, and freeze the mold again at -30°C for 2 hours. Repeat the freezing and thawing steps. The thawed material is soaked in distilled water for 3 days, and the water is changed several times a day to remove the solidification catalyst and free silk fibroin. After draining the water to a certain water content, it is disinfected and packaged.

[0029] The biological dressing manufactured in this embodiment is composed of a silk fibroin spo...

Embodiment 3

[0032] The solidification catalyst diglycidyl dicarboxylic acid diglycidyl ester was added to the 5% mass fraction of silk fibroin aqueous solution. Lay an elastic polyurethane mesh reinforcement layer on the bottom of the mold, add the solution-thin layer to the mold, and freeze at a temperature of -50 to -2°C. In this embodiment, freezing at -20°C for 4 hours is used. Remove the mold and allow the material to thaw at natural temperature. Soak the thawed material in distilled water for 3 days, change the water several times a day to remove the curing catalyst and free silk fibroin, drain the water to a certain water content, paste a porous silicone rubber film, disinfect, and package.

[0033] The pore diameter and pore distance of the porous polymer membrane can be determined according to the requirements of actual use. Generally, the pore diameter is 0.5-3mm, and the pore distance is 3-20mm.

[0034] The porous polymer film can be individually packaged and sterilized, and attac...

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Abstract

The invention discloses a biological dressing and making method of large-area skin defection therapy, which is characterized by the following: extracting silk protein from natural silk as the principal raw material; containing silk sponge cellular material single or composite with fabric netted reinforcing layer and perforated macromolecular film on the coverage of cellular material or reinforcing layer. The biological dressing provides good biological compatibility, softness-toughness, permeability of therapy medicine, strength and modulation of wound moisture, which is obvious to accelerate wound assimilation and easy to operate.

Description

Technical field [0001] The invention relates to a biological dressing and a preparation method thereof, in particular to a medical material-biological dressing made of biological materials and widely used in the treatment of large-area skin defects, and a preparation method thereof. Background technique [0002] There are a large number of skin defect patients in my country and the world every year, mainly patients with safety accidents, burn patients and patients with large areas of skin ulcers caused by diseases. The development of chemical industry and modern industry, modern weapons and frequent wars have caused the number of burn patients to remain high every year; with the rapid increase in the proportion of the elderly population and the deterioration of the environment, patients with large areas of skin ulcers caused by diabetes and other diseases have followed The increase. Therefore, the demand for biological dressings is increasing day by day. There are many types of b...

Claims

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Application Information

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IPC IPC(8): A61F13/00A61L15/00A61L15/32
Inventor 闵思佳吴豪翔朱良均
Owner ZHEJIANG UNIV
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