Hollow capsule material composition of plant polysaccharide and production of hollow capsule
A raw material composition and hollow capsule technology, which is applied in capsule delivery, drug delivery, pharmaceutical formulation, etc., can solve the problems of longer disintegration time limit and non-compliance, and achieve the effects of good stability, pollution avoidance and low investment
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Embodiment 1
[0052] The raw material composition of plant polysaccharide hollow capsules used in this example is 3 kg of K-carrageenan, 85 kg of hypromellose, 4 kg of sodium carboxymethyl starch, and 8 kg of glycerol.
[0053] Its preparation method is:
[0054] (1) Get 3 kg of K-carrageenan, 85 kg of hypromellose, 4 kg of sodium carboxymethyl starch, and 8 kg of glycerol.
[0055] (2) Put K-carrageenan, hypromellose, and sodium carboxymethyl starch in the reactor (chemical glue tank), add K-carrageenan, hypromellose, and sodium carboxymethyl starch 4 times the weight of water is used at a temperature of 70° C. to dissolve the raw materials to form a glue solution, and glycerol is added during the dissolution process of the raw materials.
[0056] (3) The formed glue solution is incubated at a temperature of 60° C. for 20 hours to grow the glue.
[0057] (4) When the temperature of the glue solution is at 35°C, perform glue dipping, drying, stripping, cutting, fitting, inspection, printi...
Embodiment 2
[0060] Used process equipment and raw material composition are basically the same as embodiment 1, only difference is that there is no sodium starch glycolate in the raw material composition, and the empty capsule of making disintegrates completely in gastric dissolution 10 minutes.
Embodiment 3
[0062] The process equipment and raw material composition used are basically the same as in Example 1, except that in the raw material composition, 1 kg of K-carrageenan, 10 kg of corn soluble starch or potato soluble starch, 98 kg of hypromellose, and 6 kg of ethanol , 6 kilograms of glycerol.
[0063] The preparation process is: put K-carrageenan, corn soluble starch or potato soluble starch, and hypromellose in a chemical tank, add K-carrageenan, corn soluble starch or potato soluble starch, and hypromellose 8 times the total weight of water, form a glue solution at 65°C, add ethanol and glycerol during the dissolution process of raw materials, and raise the glue at 30°C for 12 hours to make a hollow capsule, which will completely disintegrate within 8 minutes after gastric dissolution .
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