Hollow capsule material composition of plant polysaccharide and production of hollow capsule

A raw material composition and hollow capsule technology, which is applied in capsule delivery, drug delivery, pharmaceutical formulation, etc., can solve the problems of longer disintegration time limit and non-compliance, and achieve the effects of good stability, pollution avoidance and low investment

Active Publication Date: 2006-03-15
BEIJING IMPERIAL ISLAND MARINE BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its shortcoming is that although the amount of K-carrageenan used is relatively low, but has added potassium salt or calcium salt, the K-carrageenan potassium salt or calcium salt formed makes the disintegration time limit of the capsule longer, up to 15- 16.5min, does not meet the requirements of the current Chinese Pharmacopoeia standards, the current version of the "People's Republic of China Pharmacopoeia" requires its disintegration time limit in the stomach to be within 10 minutes

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] The raw material composition of plant polysaccharide hollow capsules used in this example is 3 kg of K-carrageenan, 85 kg of hypromellose, 4 kg of sodium carboxymethyl starch, and 8 kg of glycerol.

[0053] Its preparation method is:

[0054] (1) Get 3 kg of K-carrageenan, 85 kg of hypromellose, 4 kg of sodium carboxymethyl starch, and 8 kg of glycerol.

[0055] (2) Put K-carrageenan, hypromellose, and sodium carboxymethyl starch in the reactor (chemical glue tank), add K-carrageenan, hypromellose, and sodium carboxymethyl starch 4 times the weight of water is used at a temperature of 70° C. to dissolve the raw materials to form a glue solution, and glycerol is added during the dissolution process of the raw materials.

[0056] (3) The formed glue solution is incubated at a temperature of 60° C. for 20 hours to grow the glue.

[0057] (4) When the temperature of the glue solution is at 35°C, perform glue dipping, drying, stripping, cutting, fitting, inspection, printi...

Embodiment 2

[0060] Used process equipment and raw material composition are basically the same as embodiment 1, only difference is that there is no sodium starch glycolate in the raw material composition, and the empty capsule of making disintegrates completely in gastric dissolution 10 minutes.

Embodiment 3

[0062] The process equipment and raw material composition used are basically the same as in Example 1, except that in the raw material composition, 1 kg of K-carrageenan, 10 kg of corn soluble starch or potato soluble starch, 98 kg of hypromellose, and 6 kg of ethanol , 6 kilograms of glycerol.

[0063] The preparation process is: put K-carrageenan, corn soluble starch or potato soluble starch, and hypromellose in a chemical tank, add K-carrageenan, corn soluble starch or potato soluble starch, and hypromellose 8 times the total weight of water, form a glue solution at 65°C, add ethanol and glycerol during the dissolution process of raw materials, and raise the glue at 30°C for 12 hours to make a hollow capsule, which will completely disintegrate within 8 minutes after gastric dissolution .

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PUM

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Abstract

A medical empty capsule is prepared from K-carragheenin (0.5-26 Wt portions), the cellulose derivative and / or resin (75-98) and alcohol (1-12) through dissolving them except alcohol in water, adding alcohol to become colloidal liquid, dipping in the colloidal liquid, baking, demoulding, cutting and sleeving.

Description

technical field [0001] The invention relates to a pharmaceutical preparation, more specifically a hollow capsule for filling granular and powdery solid medicines, functional foods, health care products and cosmetics and a preparation method thereof. Background technique [0002] Hard hollow capsules have been used as drug carriers for a long time. Hard hollow capsules are generally made of gelatin and water. The production method used is that gelatin is soaked in water, expanded, stirred and dissolved in a reaction pot, and the temperature of the reaction pot is kept at 60-75°C; after dissolving, the glue is filtered, the concentration of the glue is adjusted, stored and kept warm, and peeled to remove air bubbles , on the automatic glue dipping production line, it is finished by dipping glue, drying, cooling, stripping, cutting, fitting, inspecting, and packaging. [0003] Since the raw material of gelatin comes from the skin and bone of animals, gelatin is an animal prot...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61J3/07
CPCA61K9/4816
Inventor 唐连德王元度赵丽侠唐思宇周玉坤
Owner BEIJING IMPERIAL ISLAND MARINE BIOLOGICAL TECH
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