Itraconazole dripping pill and its prepn

Abstract

The present invention discloses one kind of orally taken antifungal medicine composition, and aims at providing one kind of antifungal itraconazole dripping pill with high bioavailability, fast medicine release, fast acting, high medicine content, easy taking, low cost and production process without pollution. The itraconazole dripping pill is prepared with itraconazole as medicine material and medicine carrier as matrix.

Description

technical field [0001] The invention relates to a pharmaceutical composition with antifungal effect, in particular to an oral preparation of triazole antifungal drugs prepared from itraconazole. Background technique [0002] Itraconazole is a triazole antifungal drug with a broad antibacterial spectrum and good tolerance. Its main metabolite, hydroxyitraconazole, also has high antifungal activity. Itraconazole capsules have been used clinically for many years, mainly for the treatment of superficial fungal infections. When treating more serious systemic fungal infections, a higher stable blood concentration is required, and itraconazole capsules cannot be absorbed well. According to the rules, the blood concentration fluctuates greatly, which limits its application. Since 1992, oral solutions and intravenous injections have been developed abroad. These formulations combine itraconazole with hydroxypropyl beta-cyclodextrin (consisting of 6 glucose - 1, 4 glycosidic bond l...

AI Technical Summary

Problems solved by technology

[0008] Due to the preparation technology and other reasons, the oral preparations of most drugs, especially the oral preparations of traditional Chinese medicine, have problems such as long dissolution time, low dissolution rate, poor absorption, hepatic and intestinal first-pass effect and low bioavailability after taking. , thus affecting the efficacy of the drug and directly affecting the therapeutic effect

In addition, conventional oral dosage forms, such as tablets, capsules, granules (infusions), etc., due to the granulation process in the preparation process, will generate relatively large dust pollution, which will cause health problems to the staff to a certain extent. harm, and also cause some pollution to the environment

Although injections overcome the disadvantages of low bioavailability of conventional oral preparations, they have the disadvantages of prone to allergic reactions, inconvenient use, and great pain for patients

Furthermore, the production process of conventional oral preparations and injections is complicated and the production cost is high, so that the cost of medication for patients is also increased, which is not conducive to improving the ability of patients to seek medical treatment, and is also not conducive to improving the overall health level of society

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