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Powder injection containing red-rooted salvia

A kind of technology of Salvia miltiorrhiza and injection

Active Publication Date: 2011-01-12
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, compound salvia miltiorrhiza preparations are sold in tablets, capsules, dripping pills and other preparations, but the production technology of ordinary tablets and capsules is relatively backward, and the curative effect is poor; the dripping pill preparations have a fast onset of action and are also suitable for first aid for cardiovascular patients needs
However, there are few compound salvia miltiorrhiza preparations suitable for first aid in the existing market, which cannot meet the needs of clinical first aid.

Method used

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  • Powder injection containing red-rooted salvia
  • Powder injection containing red-rooted salvia
  • Powder injection containing red-rooted salvia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0080] The raw materials used Danshen 375g, Panax notoginseng 118g, Astragalus 100g, and Dalbergia oil 8g.

[0081] Add 0.5% hydroxypropyl-β-cyclodextrin aqueous solution to the dalbergia oil, stir to dissolve, and filter to prepare an inclusion compound solution. Extract Astragalus, Danshen and Panax notoginseng with ethanol to obtain the ethanol extract, filter the extract with gauze, collect the filtrate, concentrate the filtrate to obtain an extract with a relative density of 1.32~1.40 (55℃), add the above inclusion compound solution , Then add 49g of mannitol, add water to dissolve, coarsely filter, and the filtrate is ultrafiltered; the ultrafiltrate is pre-frozen to -40°C, kept for 3 hours, evacuated to a pressure of 13Pa and maintained in the vacuum state, within 20 hours, the temperature Raise the temperature to -7°C, then raise the temperature to 30°C within 5 hours, and keep it for 3 hours. Dispense the dry powder into sterile injection bottles under aseptic conditions...

Embodiment 2

[0084] The raw materials used Danshen 465g, Panax notoginseng 30g, Astragalus 85g, and Dalbergia odorifera 8g.

[0085] 0.5% β-cyclodextrin aqueous solution was added to the dalbergia oil, stirred to dissolve, and filtered to prepare an inclusion compound solution. Add 5 times the amount of water to the coarsely crushed Danshen and Astragalus, decoct for 2 hours, filter, and extract the filter residue for the second time. Add 4 times the amount of water, decoct for 1 hour, filter, discard the filter residue, combine the filtrate to obtain Danshen Astragalus extract. The Panax notoginseng is extracted with 70% ethanol to obtain the Panax notoginseng extract. Combine the above Danshen and Astragalus extract and Panax notoginseng extract, stand still, filter, and concentrate the filtrate to obtain an extract with a relative density of 1.32~1.40 (55℃). Add the above inclusion compound solution, then add mannitol i8g, add water Dissolve, coarsely filter, and ultrafilter the filtrate...

Embodiment 3

[0088] The raw materials used Danshen 260g, Panax notoginseng 165g, Astragalus 170g, and Dalbergia oil 8g.

[0089] Add 0.5% hydroxypropyl-β-cyclodextrin aqueous solution to the dalbergia oil, stir to dissolve, and filter to prepare an inclusion compound solution. Using 80% ethanol to extract Danshen, Panax notoginseng and Astragalus to obtain a mixed ethanol extract, the extract was centrifuged at a high speed and the supernatant was separated, and the supernatant was concentrated to obtain an extract with a relative density of 1.32~1.40 (55℃). Add the above inclusion compound solution, then add 50g of lactose, add water to dissolve, coarsely filter, and the filtrate is ultrafiltered; the ultrafiltrate is pre-frozen to -35°C, kept for 2 hours, evacuated to a pressure of 15Pa and maintained in the vacuum state, 25 Within hours, increase the temperature to -10°C, and then within 5 hours, increase the temperature to 20°C, and keep it for 5 hours. Dispense the dry powder into steril...

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Abstract

A Chinese medicine in the form of powder injection is prepared from red sage root, notoginseng, and borneol or dalbergia wood oil through extracting the active components from astragalus root, read sage root and notoginseng, dissolving in water, adding borneol or dalbergia wood oil and skeleton, dissolving, ultrafiltering, and freeze (or spray) drying.

Description

Technical field [0001] The invention relates to a Chinese medicine for treating coronary heart disease, in particular to a Chinese medicine powder injection containing Danshen. Background technique [0002] With the improvement of living standards, the aging of the world's population and the younger generation of diseased groups, the number of patients with cardiovascular and cerebrovascular diseases has increased year by year, and it has become the second most harmful disease to human health. Angina pectoris is a clinical syndrome caused by temporary ischemia and hypoxia of the myocardium, with episodic chest pain or chest discomfort as the main manifestation. Coronary heart disease angina pectoris refers to angina pectoris caused by myocardial ischemia and hypoxia caused by coronary artery hardening or spasm, accounting for about 90% of angina patients. [0003] The current methods of treatment of angina pectoris mainly focus on expanding blood vessels, reducing blood viscosity,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/537A61K36/481A61K36/258A61K9/14A61P9/10A61K31/045
Inventor 李旭郑永锋
Owner TIANJIN TASLY PHARMA CO LTD
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