N-arylation process with hydrazone as ligand in aqueous phase system

A technology of arylation and ligands, which is applied in chemical instruments and methods, preparation of amino compounds, organic chemistry, etc., can solve the problems that cannot be popularized and used, and achieve the effects of improving environmental friendliness, low temperature, and broad application prospects
CN1803760AInactive Publication Date: 2006-07-19SUN YAT SEN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SUN YAT SEN UNIV
Publication Date
2006-07-19
Estimated Expiration
Not applicable · inactive patent

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Abstract

The provided N-arylation method in water phase system for C-N coupling reaction comprises: using aryl halide and amine or nitrogen-contained heteroaromatic compound as material and water as solvent, heating traditionally or with microwave; using the carbonate, fluoride, phosphate and hydrate of alkali metal or alkali earth metal as base; with transient metal catalysis, adding surfactant to promote the C-N coupling reaction with acylated hydrazone compound as ligand. This invention just needs mild reaction condition, and has wide application.
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Description

technical field

[0001] The invention relates to the field of chemical engineering, in particular to a method for N-arylation reaction. technical background

[0002] Arylamines are an important class of compounds that widely exist in natural and non-natural products with physiological activities. The research on the C-N bond formation reaction has attracted widespread attention.

[0003] The Ullmann reaction of carbon-nitrogen cross-coupling has a long history since it was first reported in 1903 (Ley, S.V.; Thomas, A.W. Angew. Chem. Int. Ed. 2003, 42, 5400 and related citations). Since this reaction is usually carried out in a polar solution with a high boiling point, under the condition of a high temperature, a catalytic amount or an equivalent amount of copper powder as a catalyst, there are long reaction times, difficult subsequent processing of the reaction, and complex reaction products. The disadvantages such as low reaction yield. In 1983, Migita et al. first discove...

Claims

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