Fluorouracial nano particle formulation and its preparing method
A technology of fluorouracil and nanoparticles, applied in the field of medicine, can solve the problems of unfavorable eye tissue absorption, large average particle size of nanoparticles, etc., and achieve prevention of post-cataract with low cost and high particle size. narrow distribution effect
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Embodiment 1
[0033] Embodiment 1 prepares chitosan-polyacrylic acid-fluorouracil nano-preparation
[0034] Components and ratio:
[0035] Chitosan 8mg
[0036] Polyacrylic acid 40mg
[0037] Fluorouracil 100mg
[0038] Glacial acetic acid 400mg
[0039] Lactose 600mg
[0040] Distilled water 752ml
[0041] The preparation method is:
[0042] 1. Preparation of solution A: Dissolve 400 mg of glacial acetic acid in 40 ml of distilled water, add 8 mg of chitosan powder to fully swell at room temperature, and make 0.02% chitosan acetic acid solution A;
[0043] 2. Preparation of solution B: Dissolve 40mg of polyacrylic acid in 200ml of distilled water to prepare 0.02% polyacrylic acid solution B;
[0044] 3. Preparation of solution C: Dissolve 100mg of fluorouracil in 12ml of distilled water to obtain fluorouracil solution C;
[0045] 4. Preparation of nanoparticle suspension: under continuous stirring at 500rpm, add solution C dropwise to solution B at a rate of 2ml / min and pH 3-7, the...
Embodiment 2
[0053] Embodiment 2 prepares chitosan-polyacrylic acid-fluorouracil nano-preparation
[0054] Components and ratio:
[0055] Chitosan 80mg
[0056] Polyacrylic acid 400mg
[0057] Fluorouracil 500mg
[0058] Glacial acetic acid 200mg
[0059] Sucrose 1600mg
[0060] Distilled water 760ml
[0061] The preparation method is:
[0062] 1. Preparation of solution A: Dissolve 200 mg of glacial acetic acid in 40 ml of distilled water, add 80 mg of chitosan powder to fully swell at room temperature, and make 0.2% chitosan acetic acid solution A;
[0063] 2. Preparation of solution B: Dissolve 400mg of polyacrylic acid in 200ml of distilled water to prepare 0.2% polyacrylic acid solution B;
[0064] 3. Preparation of solution C: Dissolve 500mg of fluorouracil in 20ml of distilled water to obtain fluorouracil solution C;
[0065] 4. Preparation of nanoparticle suspension: under continuous stirring at 600rpm, add solution C dropwise to solution B at a rate of 2ml / min and pH 3-7, ...
Embodiment 3
[0068] Example 3 Preparation of chitosan-polyacrylic acid-fluorouracil nano-preparation
[0069] Formula and ratio:
[0070] Chitosan 800mg
[0071] Polyacrylic acid 4000mg
[0072] Fluorouracil 1000mg
[0073] Glacial acetic acid 400mg
[0074] Glycine 2400mg
[0075] Distilled water 780ml
[0076] The preparation method is:
[0077] 1. Preparation of solution A: Dissolve 400 mg of glacial acetic acid in 40 ml of distilled water, add 800 mg of chitosan powder to fully swell at room temperature, and make 2% chitosan acetic acid solution A;
[0078] 2. Preparation of solution B: Dissolve 4000mg of polyacrylic acid in 200ml of distilled water to make 2% polyacrylic acid solution B;
[0079] 3. Preparation of solution C: Dissolve 1000mg of fluorouracil in 40ml of distilled water to obtain fluorouracil solution C;
[0080] 4. Preparation of nanoparticle suspension: under continuous stirring at 700rpm, add solution A dropwise to solution B at a rate of 2ml / min, then add sol...
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