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Salangane saponin and preparation method and use thereof

A technology of petrel and saponin, which is applied to the new application of petrel saponin in expectorant and asthma, and in the field of antitussive, which can solve the problems of complicated preparation process of petrel saponin and unstable quality of saponin

Inactive Publication Date: 2006-10-04
YANTAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It mainly solves the problems of complex preparation process of petrel saponins, unstable quality of saponins, functional evaluation of petrel saponins in expectorant, antitussive and antiasthmatic, and development and utilization of petrel saponins

Method used

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  • Salangane saponin and preparation method and use thereof
  • Salangane saponin and preparation method and use thereof
  • Salangane saponin and preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0091] Example 1, put the fresh petrel in a cool and dry place to air-dry, crush it into 20-40 mesh particles with a traditional Chinese medicine grinder, weigh 10Kg of petrel dry powder, add 200Kg of 80% ethanol, extract at room temperature for 144h, and extract the extract at 0.08MPa, 50 Concentrate under reduced pressure at ℃ to obtain 10L concentrated solution, which is adsorbed on the AB-8 macroporous resin column at a rate of 5L / h. The amount of macroporous resin is 10Kg, and the adsorption volume is determined to be 5000ml. , first use 50L distilled water to elute the macroporous resin column, and control the elution rate to be 15L / h, then use 50L 20% ethanol, 50L 50% ethanol, 50L 80% ethanol to elute in sequence, and control the elution rate to be 5L / h h, collect the above-mentioned 50% ethanol eluate, concentrate under reduced pressure at 0.08MPa, 50°C, and dry under vacuum at 0.08MPa, 50°C to obtain petrel saponin. The hemolytic activity test shows that the hemolytic ...

Embodiment 2

[0092] Example 2, directly grind 10Kg of fresh petrel into 20-60 mesh particles with a meat grinder, add 100L of 80% ethanol, extract at room temperature for 72 hours, collect the extract, decompress the extract at 0.08MPa, and 50°C Concentrate to get 2L of concentrated solution. The above-mentioned concentrated solution is adsorbed on the NKA macroporous resin column at a speed of 1L / h. The amount of macroporous resin is 2Kg, and the adsorption volume is measured as 800ml. After the adsorption is completed, first use 5L of distilled water to Pore ​​resin column was eluted, and the elution rate was controlled to be 1.5L / h, and then eluted sequentially with 8L of 20%, 50%, and 80% ethanol, and the elution conditions were the same as those eluted with distilled water. The eluate was concentrated under reduced pressure and freeze-dried to obtain petrel saponins.

Embodiment 3

[0093] Example 3, after freezing 10Kg of fresh petrel, grind it into 20-60 mesh particles with a meat grinder, add 30L of methanol, extract at room temperature for 12 hours, collect the extract, and concentrate the extract under reduced pressure at 0.08MPa and 50°C , to get concentrated solution 2L, above-mentioned concentrated solution is adsorbed on NKA-9 macroporous resin column with the speed of 1L / h, and the consumption of macroporous resin is 2Kg, and adsorption volume is measured as 1000ml, after adsorption finishes, first use 4L distilled water to The macroporous resin column is eluted, and the elution rate is controlled to be 1L / h, and then eluted successively with 4L of 20%, 50%, and 80% ethanol respectively. The elution conditions are the same as elution with distilled water, and the above 50% ethanol The eluate was concentrated under reduced pressure and freeze-dried to obtain petrel saponins.

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Abstract

The disclosed preparation method for Swallow saponins comprises: cutting up fresh material, adding proper solvent to leach and concentrating raffinate; taking column chromatography, eluting with eluent then anotehr eluent; collecting to vacuum condense and dry to obtain the product with hemolysis index more than 5000H.I. / g and lots of other curative function.

Description

Technical field: [0001] The invention relates to the technical field of development and utilization of marine biological resources and the screening and application of natural active substances, in particular to preparing a petrel saponin and a preparation method thereof by using petrels of the phylum Echinodermata, class Starfish, order Echinacea, and Petrelidae, and a preparation method thereof, and petrel saponins New uses in eliminating phlegm, antitussive and antiasthma. Background technique: [0002] Petrel (Asterina pectinifera) is a common benthic animal in the waters of the Yellow Sea and Bohai Sea in my country. It is mainly distributed in the coastal waters of Yanwei Fishing Ground, the central part of the Bohai Sea and the waters near Changshan Island. It can be used as medicine in traditional Chinese medicine. Li Shizhen listed it in the "Compendium of Materia Medica" and described it in detail. Traditional Chinese medicine theory believes that Haiyan can calm t...

Claims

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Application Information

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IPC IPC(8): C07J9/00C07J17/00C07J31/00C07G3/00A61K31/704A61K31/7048A61P11/14A61P11/10A61P11/06A23L1/30
Inventor 郭承华董新伟刘传琳刘扬瑞
Owner YANTAI UNIV
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