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Medicinal composition containing cinnabar or/and realgar

A technology of composition and cinnabar, applied in the direction of drug combination, medical preparations containing active ingredients, drug delivery, etc., can solve the problems of laborious, difficult to retain active ingredients, energy consumption, etc.

Inactive Publication Date: 2006-11-01
LANZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Cinnabar and realgar are widely used as medicines, but because both of them contain excessive amounts of harmful heavy metal components and arsenic, their use is restricted. Strong reactions, even they are directly regarded as poison, cinnabar (HgS) as mercury, realgar (As 2 S 2 ) as arsenic (As) or arsenic (As 2 o 3 ), while setting strict standards to limit the content of heavy metals such as mercury and arsenic in Chinese patent medicines
[0005] The Pharmacopoeia of Traditional Chinese Medicine stipulates that cinnabar and realgar are processed by water-flying method, which is not only time-consuming, laborious and energy-consuming, but also produces waste gas and waste water pollution. More importantly, since cinnabar and realgar are extremely difficult to dissolve in water, this method cannot Effective removal of heavy metals and arsenic in medicines, resulting in excessive use of cinnabar and realgar, and the inability to quantitatively control the content of active ingredients in medicines, thus limiting the use of cinnabar and realgar, and Chinese patent medicines containing cinnabar or realgar to internationalization and secondary development
[0006] The use of chemical separation technology can completely remove the heavy metal components in the relevant mineral medicines, but practice has proved that these methods are difficult to retain the necessary active ingredients in the mineral medicines, thus losing the therapeutic effect of traditional Chinese medicine; The processing may also introduce components that the drug itself does not have, even toxic and highly toxic components into the drug. In order to avoid this phenomenon, not only relevant technological measures are required, but the cost of drug treatment is increased, and it is difficult to remove these external components.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] See Table 1 for the results of the acute toxicity test on mice of realgar A treated with the technology disclosed in our invention patent 2006102000675 and realgar B treated with the water-flying method.

[0013] mineral medicine

Embodiment 2

[0015] Add different amounts of cinnabar and realgar treated with the technology disclosed in the invention patent 2006102000675 and Niuhuang Angong Pills with cinnabar and realgar treated with the prior art, the effect on cerebral infarction in rats with middle cerebral artery embolism: 40 SD rats , divided into 4 groups, 10 rats in each group, administered 1.0ml / 100g according to body weight, and the control group and model group were given equal volume of water, and the administration was continued for 3 days. One hour after administration on the second day, focal cerebral ischemia was induced in rats by ferric chloride method, and the cerebral infarction area of ​​rats was measured. The results are shown in Table 2.

[0016] test group

Embodiment 3

[0018] Add different amounts of cinnabar and realgar (every 100ml contains cinnabar with a total mercury content of 0.005% and realgar with a total arsenic content of 0.005% treated by a bacterial method) of Qingkailing processed by the technology disclosed in the invention patent 2006102000675 Oral solution, the control group and the model group were given an equal volume of water, and administered by intragastric administration for 3 consecutive days. One hour after administration on the second day, focal cerebral ischemia was induced in rats by ferric chloride method, and the cerebral infarction area of ​​rats was measured. The results are shown in Table 3.

[0019] test group

[0020] *diluted to 1.5ml

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PUM

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Abstract

A composite medicine containing the cinnabar and / or realgar is disclosed. It features that said cinnabar and / or realgar has been treated by bacterial method for converting the water-insoluble components to the water-soluble ones, resulting in high curative effect and no or low poison.

Description

technical field [0001] The present invention relates to a pharmaceutical composition containing cinnabar and / or realgar. Specifically, cinnabar and / or realgar that has been dissolved by microorganisms and removed harmful heavy metals is used in the pharmaceutical composition to prepare cinnabar and / or realgar. pharmaceutical composition. Background technique [0002] Cinnabar (cinnabaris) is also known as cinnabar and cinnabar. Its chemical composition is mainly mercury sulfide (HgS). In addition, cinnabar contains 25 trace elements such as lead, barium, magnesium, iron, zinc, and manganese. Cinnabar is sweet in taste, slightly cold, clears away heart-fire and calms convulsions, soothes the nerves and detoxifies. Used for palpitations, insomnia and dreaminess, epilepsy, convulsions in children, blurred vision, aphtha, sore throat, sores and swelling. Due to the good curative effect of cinnabar, medical scientists of successive dynasties have created many famous prescripti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/36A61K9/00A61P9/10A61P29/00A61P35/00
Inventor 李红玉支德娟张景红
Owner LANZHOU UNIVERSITY
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