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Use of oligose ester in preventing and treating depression

A depression and oligosaccharide technology, applied in medical preparations containing active ingredients, organic active ingredients, nervous system diseases, etc., can solve the problems of high price, poor antidepressant effect, toxic and side effects, etc.

Inactive Publication Date: 2006-11-08
GENERAL HOSPITAL OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing antidepressants are mainly: tricyclics (TCAs), selective 5-HT reuptake inhibitors (SSRIs), monoamine oxidase inhibitors (MAOIs), they all have different degrees of toxic and side effects, and are expensive
In addition, there are still about 1 / 3 of depressed patients who do not respond well to these antidepressants in clinical use

Method used

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  • Use of oligose ester in preventing and treating depression
  • Use of oligose ester in preventing and treating depression
  • Use of oligose ester in preventing and treating depression

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0008] Example 1 Preparation of oligosaccharide esters and determination of intestinal absorption

[0009] 1 material

[0010] 1.1 Animals Healthy male SD rats, 250-300 g, were provided by the Experimental Animal Center of the Academy of Military Medical Sciences of the Chinese People's Liberation Army. Animal license number SCXX-(Army) 2002-2001.

[0011] 1.2 Drug reagents Polygala is provided by the Chinese Pharmacy of the General Hospital of the Chinese People’s Liberation Army. It is the dried root of Polygala tenuifolia Willd., a plant of the Polygala family. TM Medium 199 medium powder (containing Earle's salt and L-glutamine, without sodium bicarbonate, Cat.No.31100-035, Lot No.1141059, Invitrogen Corp., USA). NaCHO 3 , normal saline. Acetonitrile (HPLC grade, Fisher Scientific Corp.), purified water (Hangzhou Wahaha Company).

[0012] 1.3 Instruments Constant temperature water bath, Agilent1100 high performance liquid chromatography, DAD monitor, Zorbax SB-C18 co...

Embodiment 2

[0032] Example 2: Effects of oligosaccharide esters on central neurotransmitters and plasma cortisol in forced swimming mice

[0033] 1 material

[0034] 1.1 Animals Male KM mice, weighing 22±2g, were provided by the Experimental Animal Center of the Academy of Military Medical Sciences.

[0035] 1.2 Drugs and reagents The sample prepared by Example 1; Desipramine (Desipramine, Sigma Company); Norepinephrine (Norepinephrine, NE, Sigma Company); Dopamine (Dopamine, DA, Sigma Company); (5-hydroxytryptamine, 5-HT, Sigma company); 5-hydroxyindole acetic acid (5-hydroxyindole-3-acetic acid, 5-HIAA, Sigma company); Cortisol kit (East Asian Immunology Institute); Sodium; perchloric acid (Beijing Reagent Factory, analytically pure); methanol (Beijing Reagent Factory, chromatographically pure).

[0036] 1.3 Instruments Model 1050 High Performance Liquid Chromatograph (Hewlett Packard, USA); Fluorescence Detector Model 1046 (Hewlett Packard, USA); Bondapar Phenyl Chromatographic Colum...

Embodiment 3

[0063] Example 3: Effects of Oligosaccharide Ester on Behavior and Hippocampal P-CREB Expression of Chronic Stressed Rats

[0064] 1. Materials:

[0065] 1.1 Animals: healthy male class II wistar rats, weighing 150-180 g at the time of enrollment, provided by the Animal Center of the Academy of Military Medical Sciences, certificate number: SCXK-(Army) 2002-001.

[0066] 1.2 Drug: the sample prepared according to Example 1; the positive control drug desipramine is a product of sigma company, and it is prepared with normal saline to make 1 mg / ml before use; the blank control is normal saline.

[0067] 1.3 Reagents: APES glue, two-step immunohistochemical detection kit (PV6001), EDTA antigen retrieval solution, DAB kit, and PBS were all purchased from Beijing Zhongshan Biotechnology Co., Ltd. Rabbit anti-p-CREB polyclonal antibody was purchased from Santa Cruz, USA.

[0068] 2. Method:

[0069] 2.1 Grouping, modeling and administration: All rats were scored by the Open-filed ...

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Abstract

The present invention relates to oligose ester extracted from Chinese medicinal material and possessing obvious treating effect on depression and anxiety neurosis. The oligose ester is extracted from polygala, and may be prepared into different preparation forms. It is suitable for treating various types of depression caused by chronic and acute stress and diseases, owing to its functions of increasing contents of NE, 5-HT and their metabolite 5-HIAA in body, activating 5-HT neuron in brain, lowering the content of corticosteroid in plasma, increasing the p-CREB expression of hippocampal areas, raising the expression of cerebral neurotrophic factor and its induced gene transcription and promoting the recovery of damaged cerebral neuron.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and mainly relates to oligosaccharide ester components extracted from natural medicines, including feruloyl sucrose, sinapinyl sucrose, trimethoxycinnamoyl sucrose, biserapinyl sucrose, p-hydroxybenzoyl trimethoxy Cinnamoyl sucrose, sinapinyl trimethoxycinnamoyl sucrose. Such ingredients can be used to treat depression symptoms caused by various reasons, and can be used to prepare various antidepressant products. technical background [0002] Depression is the main type of affective disorder, characterized by significant and persistent low mood. In 1996, the World Health Organization (WHO) released a survey on the "Global Burden of Disease", which showed that depression had become the fourth largest disease in the world in 1990, accounting for 3.7% of the total disease burden; It is the second largest disease after ischemic heart disease, accounting for 5.7% of the total disease burd...

Claims

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Application Information

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IPC IPC(8): A61K31/7024A61P25/24
Inventor 刘屏王东晓汪进良陈宜鸿王波戴畅王虹谢婷婷崔捷
Owner GENERAL HOSPITAL OF PLA
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