Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Aspirin slow-release tablet and its prepn. method

A technology of aspirin and sustained-release tablets, applied in the field of human medicine, can solve the problems of seldom application, large dose, gastrointestinal bleeding, etc., and achieve the effects of improving compliance, improving absorption rate, and prolonging action time.

Active Publication Date: 2006-11-29
哈尔滨格拉雷药业有限公司
View PDF0 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As an antipyretic and analgesic, aspirin has been used clinically for more than 100 years. Because it is used in large doses for antipyretic and analgesic, it is easy to cause gastrointestinal bleeding. seldom used

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] Aspirin sustained-release tablets, its composition includes: aspirin, starch, hypromellose, polyacrylic resin No. II, white dextrin, talc, tartaric acid, Tween-80, 75% ethanol, the above The weight ratio of the ingredients is 50 aspirin, starch 1, hypromellose 2.48, polyacrylic resin II 3.6, white dextrin 1, talc 3, tartaric acid 0.21, Tween-80 is 0.15, 75 % Ethanol 12.

[0076] Administration method and dosage, 50-150mg (1-3 tablets) each time orally, once a day or as directed by a doctor.

Embodiment 2

[0078] The above-mentioned preparation process of aspirin sustained-release tablets takes hypromellose 0.48, polyacrylic resin II 0.6, tartaric acid 0.21, Tween-80 0.15, and 75% ethanol 12 to prepare a solution for bonding. Add aspirin 50, starch 1, hypromellose 2, polyacrylic resin No. 2 3, white dextrin 1, put in a mixer for 10 minutes, and then add the prepared adhesive It is wet mixed for 100 seconds to make a soft material, granulated by a 20-mesh screen, dried by a boiling dryer, and controlled the inlet air temperature not to be higher than 100°C. Add talc powder 3 to the dry granule, and granulate with an 18-mesh screen. The prepared granules are compressed with a press to obtain aspirin sustained-release tablets.

Embodiment 3

[0080] For the bioavailability experiment of aspirin sustained-release tablets, the single-dose subjects were randomly divided into two groups (A, B), and carried out according to the crossover test. Group A was self-made sustained-release tablets, and group B was enteric-coated tablets. Each medication was taken one week apart. The subjects were taken blood on an empty stomach in the morning, followed by taking the medication. The blood was taken with 150ml of warm water. The blood collection time was 0, 1, 1.5, 2, 3, 4, 5, 6, 8, 10, 12, 24. After hours, venous blood was taken, after processing, the plasma was taken, stored at low temperature, and determined by HPLC method.

[0081] Drug source: experimental drugs, aspirin sustained-release tablets each containing 50mg of the main drug, the actual content is 101.20%. The reference substance, aspirin enteric-coated tablets (25mg / tablet), the actual content is 100.86%, produced by Jinan No. 3 Pharmaceutical Factory.

[0082] Dosage...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A slow-release aspirin tablet for treating transient cerebral ischemia attack, myocardial infarction, thrombosis, unstable angina pectoris, etc is proportionally prepared from aspirin, starch, hydroxypropyl methylcellulose, polyacrylic resin No.2, white dextrin, tartaric acid, tween-80 and alcohol. Its preparing process is also disclosed.

Description

Technical field: [0001] The invention relates to a human medicine, which is an oral aspirin sustained-release tablet. Background technique: [0002] Antithrombotic drugs are a major category in the cardio-cerebral blood management medication system. The clinically commonly used drugs include heparin, streptokinase, urokinase, dicoumarin, dipyridamole, etc., among which different drugs have different anticoagulant properties. Mechanism, most drugs interfere with a certain link in the coagulation process by participating in the biochemical reactions in the human body. As an antipyretic and analgesic, aspirin has been clinically used for more than one hundred years. Because of its large dosage for antipyretic and analgesic, it is easy to cause gastrointestinal bleeding. It has been rarely applied. However, recent studies have shown that small doses of aspirin can directly inhibit the aggregation of platelets, thereby producing anticoagulant effects. Since aspirin has been produced f...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/616A61K9/22A61P7/02
Inventor 张利
Owner 哈尔滨格拉雷药业有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com