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Ranitidine bismuth citrate dispersible tablet, and its preparing method

A technology of bismuth citrate ranitidine and bismuth citrate, applied in the field of medicine, can solve the problems of drug dissolution, uneven dispersion, slow disintegration, etc., and achieves increasing dissolution rate, overcoming slow disintegration, and promoting penetration. effect of action

Inactive Publication Date: 2007-01-10
张嵩
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In order to solve the shortcomings of the single dosage form of bismuth citrate ranitidine in the prior art, overcome the shortcomings of slow disintegration and uneven dispersion of capsules and ordinary tablets, and slow drug dissolution and absorption, the invention provides a bismuth citrate Ranitidine dispersible tablet, a tablet capable of disintegrating and dispersing within 3 minutes and preparation method thereof

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0029] Bismuth Citrate Ranitidine 100g

[0030] Microcrystalline cellulose 50~100g

[0031] Sodium carboxymethyl starch 50~100g

[0032] Lactose 50~80g

[0033] Crospovidone 10~20g

[0034] Appropriate amount of adhesive

[0035] Appropriate amount of sweetener

[0036] Appropriate amount of lubricant

[0037] Flavor Appropriate amount

[0038] Ethanol 20~40ml

[0039] Water 50~100ml

[0040] Preparation:

[0041] 1. Grinding and sieving Take the main drug of bismuth ranitidine citrate, microcrystalline cellulose, sodium carboxymethyl starch, lactose, crospovidone and other pharmaceutical excipients and grind them separately and pass through 80-100 mesh sieves.

[0042] 2. Soft materials

[0043] Mix the above powders evenly, add binders such as 1% PVP (40% ethanol) solution, and make a soft material.

[0044] 3. Granulation and granulation

[0045] Use a 20-30 mesh sieve to granulate, dry at 50-80°C for 2 hours, granulate through a 20-30 mesh sieve, add essence, l...

example 2

[0051] Bismuth Citrate Ranitidine 200g

[0052] Low-substituted hydroxypropyl cellulose 50~100g

[0053] Sodium carboxymethyl starch 50~100g

[0054] Lactose 50~80g

[0055] Cross-linked methyl cellulose sodium 10~20g

[0056] Appropriate amount of adhesive

[0057] Appropriate amount of sweetener

[0058] Appropriate amount of lubricant

[0059] Flavor Appropriate amount

[0060] Ethanol 20~40ml

[0061] Water 50~100ml

[0062] Preparation:

[0063] 1. Grinding and sieving to take the main drug of bismuth ranitidine citrate, low-substituted hydroxypropyl cellulose, sodium carboxymethyl starch, lactose, cross-linked polycellulose sodium and other pharmaceutical excipients were respectively crushed, passed through 80-100 Mesh sieve.

[0064] 2. Soft materials

[0065] Mix the above powders evenly, add binders such as 1% PVP (40% ethanol) solution, and make a soft material.

[0066] 3. Granulation and granulation

[0067] Use a 20-30 mesh sieve to granulate, dry at ...

example 3

[0073] Bismuth Citrate Ranitidine 350g

[0074] Starch 50~100g

[0075] Sodium carboxymethyl starch 50~100g

[0076] Lactose 50~100g

[0077] Croscarmellose Sodium 10~50g

[0078] Appropriate amount of adhesive

[0079] Appropriate amount of sweetener

[0080] Appropriate amount of lubricant

[0081] Flavor Appropriate amount

[0082] Ethanol 20~40ml

[0083] Water 50~100ml

[0084] 1. Grinding and sieving Take the main drug of bismuth ranitidine citrate, starch, sodium carboxymethyl starch, lactose, cross-linked polycellulose sodium and other pharmaceutical excipients, respectively pulverize and pass through a 80-100 mesh sieve.

[0085] 2. Soft materials

[0086] Mix the above powders evenly, add binders such as 1% PVP (40% ethanol) solution, and make a soft material.

[0087] 3. Granulation and granulation

[0088] Use a 20-30 mesh sieve to granulate, dry at 50-80°C for 2 hours, granulate through a 20-30 mesh sieve, add essence, lubricant magnesium stearate, talcum...

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Abstract

The present invention relates to a bismuth citrate ranitidine dispersion tablet and its preparation method. Said tablet preparation contains bismuth citrate ranitidine compound and medicinal auxiliary material. Its preparation method includes the following steps: (1), pulverization and mesh screening, respectively pulverizing bismuth citrate ranitidine main medicines and medicinal auxiliary material, mesh screening by means of sieve with 80-100 meshes; (2), making soft material, uniformly mixing the above-mentioned all the medicinal materials and adding ethyl alcohol or aqueous solution of povidone K30 as adhesive, and making them into soft material; (3), granulation and granule finishing, using sieve with 20-30 meshes to make granulation, drying for 2hr at 50-80 deg.C, then finishing granules by using sieve with 20-30 meshes; and (4), content determination, tabletting so as to obtain the invented finished product.

Description

Technical field: [0001] The invention relates to a medicine, in particular to a bismuth citrate ranitidine dispersible tablet and a preparation method thereof. Background technique: [0002] Bismuth ranitidine citrate is an anti-peptic ulcer drug. It is a double salt formed by bismuth citrate complex and ranitidine. It has the functions of ranitidine inhibiting gastric acid secretion, bismuth salt inhibiting protease and protecting stomach Mucous membrane, and the three effects of the two together inhibiting Helicobacter pylori are better than those of ranitidine or bismuth potassium citrate alone. But so far, the oral dosage forms at home and abroad are single, only hard capsules and ordinary tablets, which cannot meet the needs of patients. Moreover, capsules and ordinary tablets disintegrate slowly, disperse unevenly, and drug dissolution and absorption are slow. Invention content: [0003] In order to solve the shortcoming of the single dosage form of bismuth citrate ...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/341A61P1/04
Inventor 张嵩张对良
Owner 张嵩
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