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Antibiotic peptide Babu plaster and its preparing method

A technology of antimicrobial peptide and non-woven fabric, which is applied in the field of antimicrobial peptide cataplasm and its preparation, which can solve the problems of adhesive tape allergic reaction, toxicity, skin irritation, etc., and achieve good air permeability, suitable skin adhesion, and not easy The effect of drug resistance

Active Publication Date: 2010-06-09
SHANGHAI HI TECH BIOENG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The antibacterial ingredients contained in it are all chemical ingredients. Although they have certain bactericidal activity, they are irritating or even toxic to the skin.
In addition, the tape that adheres to the skin can cause allergic reactions

Method used

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  • Antibiotic peptide Babu plaster and its preparing method
  • Antibiotic peptide Babu plaster and its preparing method
  • Antibiotic peptide Babu plaster and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The preparation of embodiment 1 antimicrobial peptide cataplasm

[0030] Formula and its ratio (about 30ml in total):

[0031] Phase I solution: 5.5g (18.3%) of gum arabic, 2.5g (8.3%) of polyvinylpyrrolidone, 12g (40%) of glycerin, 2mL of water;

[0032] Phase II solution: gelatin 3g (10%), water 8mL

[0033] Antimicrobial peptide: 300ug (10ppm)

[0034] GKV-1: Lys Gly Ala Arg Lys Gly Ala Lys Arg Gln Gly Gly Lys Lys Val Ala Arg Lys Ala LeuLys Arg Ala Gly Lys

[0035] The remainder is water.

[0036] Preparation:

[0037] 1. Prepare phase I solution: disperse gum arabic and polyvinylpyrrolidone in glycerin and water, and stir well to form a paste to obtain phase I solution;

[0038] 2. Preparation of phase II solution: After fully swelling the gelatin in water, heat and dissolve in a water bath at 60°C to obtain phase II solution;

[0039] 3. Prepare the antimicrobial peptide aqueous solution: add the antimicrobial peptide to water to dissolve, and stir to obtain ...

Embodiment 2

[0041] Embodiment 2 antimicrobial peptide cataplasm in vitro bactericidal test

[0042] 1. Preparation of test samples:

[0043] (1) antimicrobial peptide cataplasm sample: prepared by the method of Example 1,

[0044] Phase I solution: 5.5g gum arabic, 2.5g polyvinylpyrrolidone, 12g glycerin;

[0045] Phase II solution: 2.5-3g gelatin, 8mL water

[0046] Antimicrobial peptide: 300ug (10ppm) and the balance is water.

[0047] GKV-2: Lys Gly Gly Arg Lys Gly Ala Lys Arg Gln Gly Gly Lys Lys Lys Leu Ala Arg Lys AlaLeu Lys Arg Ala Gly Arg

[0048] (2) Control sample:

[0049] Phase I solution: 5.5g gum arabic, 2.5g polyvinylpyrrolidone, 12g glycerin;

[0050] Phase II solution: 2.5-3g gelatin, the balance is water.

[0051]2. Test strains: Staphylococcus aureus CMCC26003, Bacillus subtilis DB430, Escherichia coli ATCC8099, Klebsiella pneumoniae CMCC46117, Pseudomonas aeruginosa CMCC10104, Candida albicans ATCC10231. (The above strains are from China Institute for the Control...

Embodiment 3

[0064] Example 3 Acute Toxicity Test in Animals

[0065] 1. Sample: antimicrobial peptide solution, that is, to dissolve the antimicrobial peptide in water so that the injection dose of the antimicrobial peptide reaches 1mg / kg. The sequences are:

[0066] GKV-2: Lys Gly Gly Arg Lys Gly Ala Lys Arg Gln Gly Gly Lys Lys Leu Ala Arg Lys Ala LeuLys Arg Ala Gly Arg

[0067] GKV-3: Lys Gly Gly Arg Lys Gly Ala Lys Arg Gln Gly Gly Lys Lys Leu Ala Arg Lys Ala LeuLys

[0068] 2. Experimental animals: 60 Kunming mice, half male and half male, weighing 33.5±0.25g, were provided by the Experimental Animal Department of Fudan University.

[0069] 3. Test method: intramuscularly inject mice once a day for 7 consecutive days, and observe the toxic reaction of the animals at the maximum dose. The experimental results showed that after 7 days of intramuscular injection, the animals had no abnormal reaction and their activities were normal. After 7 days of observation, all 60 mice survived. P...

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Abstract

The present invention relates to antibiotic preparation for skin, and is especially a kind of antibiotic peptide plaster and its preparation process. The antibiotic peptide plaster consists of antibiotic peptide, matrix, non-woven fabric and anti-sticking film, and the matrix consists of water soluble high molecular compound gelatin, Arabic gum, poly vinylpyrrolidone and glycerin. The preparationprocess of the antibiotic peptide plaster includes the following steps: prepare solution I and solution II with water soluble polymer, mixing the solution I and the solution II, adding prepared watersolution of antibiotic peptide, smearing onto non-woven fabric, air drying and covering with anti-sticking film to form the antibiotic peptide plaster. The antibiotic peptide plaster has high antibiotic effect, high air permeability, proper stickness to skin and no residual matrix after being torn off.

Description

technical field [0001] The invention relates to an antibacterial preparation for skin, in particular to an antibacterial peptide cataplasm and a preparation method thereof. Background technique [0002] At present, the preparations for the treatment of small wounds and abrasions on the skin or mucous membranes sold in the domestic and foreign markets, including drugs or disinfectants, hygiene products and other products, are mainly dressings containing bactericidal ingredients. Wounds, abrasions and other affected areas can help prevent the invasion of bacteria and foreign objects and accelerate wound healing. The antibacterial ingredients contained in it are all chemical ingredients. Although they have certain bactericidal activity, they are irritating or even toxic to the skin. In addition, the tape that adheres to the skin can cause allergic reactions. The current market needs an external antibacterial preparation for damaged skin that can effectively clean and antibact...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/16A61K38/10A61K9/70A61P17/02
Inventor 黄青山李国栋
Owner SHANGHAI HI TECH BIOENG
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