Artificial blood vessel silk fibroin and collagen blending pre-coagulation coating

Abstract

The invention discloses a stratified pre-condensing coating method of artificial vessel collagen and silk protein, which comprises the following steps: synthesizing vessel prosthesis through woven or knitted elastic porous pipe structure, using three-layered coating technology to coat collagen and reinforcer liquid on the internal wall of vessel prosthesis. The vessel prosthesis of silk protein liquid vessel needs composite reinforcer, which is coated in the base layer evenly to expose in the formaldehyde steam after drying.

Description

Technical field [0001] The present invention relates to a pre-coagulation coating method of artificial vascular prosthesis which can be used for replacement, bypass grafting or shunting any part of human vascular system, especially the layered coating of silk fibroin and collagen liquid mixed with plasticizer Artificial vascular prosthesis, so that it does not leak blood so as to avoid the method of pre-coagulation operation during the operation. Background technique [0002] Replacing diseased blood vessels in the human body with artificial vascular prostheses is a well-established surgical technique. Artificial blood vessels come in many different types and can be constructed of different materials. Artificial vascular prostheses that can be implanted into the human body are usually made of biocompatible materials, and at the same time, the vascular prosthesis can maintain an open tubular structure and allow blood flow to run unimpeded after implantation. Vascular prosth...

AI Technical Summary

Problems solved by technology

The artificial blood vessels prepared according to the above methods basically meet the requirements of vascular surgery in the last century. However, with the development of vascular surgery technology, the original complex vascular diseases are now mostly treated with active surgical intervention and one-stage surgery as far as possible. The surgical operation is complicated. Prolonged operation time puts higher demands on artificial blood vessels

Experiments have shown that the albumin-coated artificial blood vessel coating material degrades 80% after 7 days in the in vitro degradation test, while the gelatin-coated blood vessel prosthesis coating material only remains about 1%. The collagen-coated artificial blood vessel implanted in dogs After 6 days in the body, nearly half of the coating material is degraded and absorbed, and at this time the vascular prosthesis has not been completely wrapped and healed by the recipient tissue, which can lead to increased postoperative exudate during clinical full-thoracoabdominal and full-aortic blood vessel replacement , increasing the chance of infection (Guidoin R, MarceauD, Rao TJ, "In vitro and in vivo characterization of an impervious polyester arterial prosthesis: the Gelseal Triaxial graft.", Biomaterials, 8(6): 433-41., (1987); Yamamoto K, Noishiki Y, Mo M, "Disadvantages of"Gelseal graft"as a vascular prosthesis", The Japanese journal of thoracic surgery, 46(9):762-6, (1993)

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