Fusion albumen containing HSP70 ATPase structure field and mammal p53 albumen and application thereof

A fusion protein, mammalian technology, applied in the field of fusion proteins, can solve the problems of low expression of fusion proteins, difficult to scale industrial production, and amplification, and achieve the effects of less adverse reactions and good immune effects.
CN1919873AActive Publication Date: 2007-02-28BEIJING SUNBIO BIOTECH
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
BEIJING SUNBIO BIOTECH
Publication Date
2007-02-28

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Abstract

The invention discloses a framework area including human HSP70 ATPase and human papillomavirus E7, E6 protein or merge protein of mammalian p53 protein. The invention also discloses a pharmaceutical compound of merge protein, gene of encoding merge protein, the expressive carrier of merge protein and the usage of preparing medicine to treat or avoid tumor as human papillomavirus or tumor related to p53 protein overdose express.
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Description

Technical field

[0001] The invention relates to a fusion protein comprising a heat shock protein adenosine triphosphate (ATPase) domain and an antigen peptide, more specifically, the invention relates to a fusion protein comprising a human HSP70 ATPase domain and a mammalian p53 protein. The present invention also relates to a pharmaceutical composition comprising the above-mentioned fusion protein, a gene encoding the above-mentioned fusion protein, an expression vector comprising the gene, and use thereof in the preparation of a medicine for treating or preventing tumors related to overexpression of p53 protein. Background technique

[0002] It was discovered a long time ago that heat shock protein (Hsp) can promote the correct folding of protein molecules. Recently, it has been discovered that Hsp70, Hsp90, and Grp94 (also called gp96) can submit tumor antigen peptides to the MHC molecules of antigen presenting cells (antigen presenting cells, APCs) and be recognized by T cell...

Claims

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