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Pharmaceutical composition comprising notoginseng extract, Danshen extract and ligustrazine

A technology of composition and extract, which is applied in the field of medicine to achieve the effects of improved drug efficacy, wide application prospects, and simple preparation process

Inactive Publication Date: 2007-03-07
JIANGYIN TIANJIANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moreover, there is no report on the medicine of treating cardiovascular and cerebrovascular diseases by utilizing the interaction of Panax notoginseng, Salvia miltiorrhiza and Ligustrazine phosphate in combination.

Method used

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  • Pharmaceutical composition comprising notoginseng extract, Danshen extract and ligustrazine

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0031] Experimental Example 1 The optimal process for the preparation of Panax notoginseng extract

[0032] Take the medicinal materials of Panax notoginseng, pulverize them into coarse powder, add ethanol for reflux extraction 3 times, 3 hours each time, filter, recover ethanol from the filtrate until there is no alcohol smell, add water to an appropriate amount (each 1 ml is equivalent to 2 g of the original medicinal material), refrigerate for 24 hours, Filtration, adding the filtrate to the treated weakly polar macroporous resin column, first eluting with 2 times the column volume of water, then eluting with 4 to 5 times the 80% ethanol, collecting the eluate, and recovering the ethanol And vacuum drying, that is.

experiment example 2

[0033] Experimental example 2: Determination test of total saponins content of Panax notoginseng in Panax notoginseng extract

[0034] Preparation of reference substance solution Take 10 mg of Panax notoginseng saponins reference substance, vacuum dry at 60°C for 2 hours, accurately weigh, put in a 25ml volumetric flask, add methanol to dissolve and dilute to the mark, shake well, filter with dry filter paper, Precisely measure 5ml of the continuous filtrate, put it in a 25ml volumetric flask, add methanol to dilute to the mark, and shake well.

[0035] Preparation of the test solution: Take 15mg of this product, accurately weigh it, put it in a 25ml measuring bottle, add methanol to dissolve and dilute to the mark, shake well, filter through dry filter paper, accurately measure 5ml of the subsequent filtrate, and place it in a 25ml measuring bottle , add methanol to dilute to the mark, shake well, and get it.

[0036] Determination method Precisely measure 1ml of the test so...

experiment example 3

[0039] Experimental Example 3 Salvia Extraction Technology Screening Test

[0040] 1. Water extraction process screening test

[0041] The amount of water, extraction time and extraction times have great influence on the extraction results. Therefore, taking the total phenolic acid content of Salvia miltiorrhiza and the extract yield as indicators, the influence of three factors on the extraction results was investigated by orthogonal test method. The factors and level design are shown in Table 2.

[0042] Level / Factor

[0043] Test method Weigh 100g of Salvia miltiorrhiza, a total of 9 parts, extract according to the requirements of each column number in Table 2, combine the extracts, filter, concentrate the filtrate and dilute to 500ml, for use.

[0044] Determination of total phenolic acids in dandelion

[0045] Preparation of reference solution Precisely weigh 1 mg of dry protocatechualdehyde reference substance, dissolve in water, and make up to 100 ml.

[00...

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PUM

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Abstract

The invention belongs to the field of pharmacy, and discloses a medicinal composition containing pseudo-ginseng extract, red sage root extract, ligustrazine or pharmaceutically acceptable salts, which can be used for treating cardiovascular and cerebrovascular diseases, the invention also discloses the preparation containing the pharmaceutical composition and its preparing process, wherein the constituents include (by weight ratio) pseudo-ginseng extract 30-400 parts, red sage root extract 10-400 parts, ligustrazine or its pharmaceutically acceptable salts 10-400 parts, the composition can be prepared into any clinically or pharmaceutically acceptable dose forms, preferably injections.

Description

[Technical field] [0001] The invention belongs to the technical field of medicine, and relates to a medicinal composition containing Panax notoginseng extract, Salvia miltiorrhiza extract and ligustrazine, a preparation containing the medicinal composition and a preparation method thereof. [Background technique] [0002] Cardiovascular and cerebrovascular diseases have always been known as the number one killer that threatens human health. According to relevant survey reports, more than 3 million people die of cardiovascular and cerebrovascular diseases in my country every year, accounting for 50% of the total number of deaths in my country every year. 75% of the people lost their ability to work to varying degrees, and 4% were severely disabled. In particular, the age of onset and death is becoming younger and younger, and how to effectively prevent and control it has aroused great attention. [0003] Cardiovascular and cerebrovascular diseases include coronary heart diseas...

Claims

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Application Information

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IPC IPC(8): A61K36/537A61P9/00A61P9/10A61P9/12A61P3/06A61K31/4965
Inventor 蔡军
Owner JIANGYIN TIANJIANG PHARMA
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