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Voltage endurance vitamin E microcapsule and its preparing process

A vitamin and pressure-resistant technology, used in microcapsules, capsule delivery, pharmaceutical formulations, etc., can solve the problems of inconvenient transportation and measurement, oxidative deterioration of vitamin E, low mechanical strength, etc., and achieve excellent emulsification and enhanced mechanical strength. , the effect of good liquidity

Inactive Publication Date: 2007-03-14
PKU HEALTHCARE CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Vitamin E is a golden yellow or light yellow viscous oily liquid at room temperature. It is inconvenient to transport and measure, and it is unstable because of its oxidation. Therefore, vitamin E microencapsulated powders with a content of 20% to 70% have been developed at home and abroad. However, when it is directly used in tablets, it is easy to break the capsule because the mechanical strength of the capsule is not high, and the content becomes lower during the stability study, indicating that vitamin E oxidizes and deteriorates after the capsule breaks.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Vitamin E 50%

[0022] Gelatin 5%

[0023] Dextrin 12%

[0024] Starch Octenylsuccinate 32%

[0025] Micronized silica gel 1%

[0026] Purified water 1.5 times the weight of the total solids

[0027] Preparation:

[0028] 1. Water phase: Heat the purified water of the prescribed amount to 65-70°C, slowly add the prescribed amount of gelatin, octenyl succinate starch, dextrin and micropowder silica gel, and stir for 10 minutes to disperse evenly.

[0029] 2. Oil phase: Preheat the prescribed amount of vitamin E oil to 65-70°C.

[0030] 3. Emulsification and homogenization: slowly add the oil phase to the water phase, stir and emulsify for 30-40 minutes, homogenize 3 times under the pressure of 40-45Mpa, take the emulsion and observe under the microscope, it should be completely encapsulated and the size is about 10μm, if not When the requirements are met, it can be homogeneously observed again.

[0031] 4. Spray drying: Add the emulsion into the centrifugal spray ...

Embodiment 2

[0034] Vitamin E 55%

[0035] Sodium Caseinate 9%

[0036] Lactose 10%

[0037] Starch Octenylsuccinate 25%

[0038] Micronized silica gel 1%

[0039] Purified water 1.5 times the weight of the total solids

[0040] Preparation:

[0041] 1. Water phase: Heat the purified water of the prescribed amount to 65-70°C, slowly add the prescribed amount of sodium caseinate, octenyl succinate starch, lactose and micropowder silica gel, and stir for 10 minutes to disperse evenly.

[0042] 2. Oil phase: Preheat the prescribed amount of vitamin E oil to 65-70°C.

[0043] 3. Emulsification and homogenization: slowly add the oil phase to the water phase, stir and emulsify for 30-40 minutes, homogenize 3 times under the pressure of 40-45Mpa, take the emulsion and observe under the microscope, it should be completely encapsulated and the size is about 10μm, if not When the requirements are met, it can be homogeneously observed again.

[0044] 4. Spray drying: Add the emulsion into the ...

Embodiment 3

[0047] Vitamin E 60%

[0048] Chitosan 6%

[0049] Lactose 12%

[0050] Octenyl succinate starch 20.8%

[0051] Micronized silica gel 1.2%

[0052] Purified water 1.5 times the weight of the total solids

[0053] Preparation:

[0054] 1. Water phase: Heat the purified water of the prescribed amount to 65-70°C, slowly add the prescribed amount of chitosan, octenyl succinate starch, lactose and micropowder silica gel, and stir for 10 minutes to disperse evenly.

[0055] 2. Oil phase: Preheat the prescribed amount of vitamin E oil to 65-70°C.

[0056] 3. Emulsification and homogenization: slowly add the oil phase to the water phase, stir and emulsify for 30-40 minutes, homogenize 3 times under the pressure of 40-45Mpa, take the emulsion and observe under the microscope, it should be completely encapsulated and the size is about 10μm, if not When the requirements are met, it can be homogeneously observed again.

[0057] 4. Spray drying: Add the emulsion into the centrifugal...

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Abstract

The invention relates to pressure resistant vitamin E capsules, wherein the constituents include (by weight percent) vitamin E oil 50-70%, capsule material 1-25%, auxiliary capsule material 5-30%, octenylsuccinate starch 10-30%, flow aid 0.5-2%. The invention also relates to the process for preparing the capsules.

Description

technical field [0001] The invention relates to a pressure-resistant vitamin E microcapsule and a preparation method thereof. technical background [0002] Vitamin E, also known as tocopherol, is a commonly used drug and nutritional health product. It has become the main vitamin variety with the most uses and the largest production and sales in the international market. The most prominent chemical property of vitamin E is anti-oxidation, which can enhance the anti-oxidation of cells, and can be used to maintain the integrity of various cell membranes; participate in the various metabolic processes of certain cell tissues as a whole; maintain the activity of membrane-bound enzymes In addition, it has anti-aging effect, anti-coagulation effect, enhances immunity, improves peripheral blood circulation, prevents arteriosclerosis, maintains the integrity of red blood cells, white blood cells, brain cells, and epithelial cells, thereby maintaining Normal function of muscles, neur...

Claims

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Application Information

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IPC IPC(8): A61K9/50A61K31/355A61K47/36A61K47/42A61P3/02
Inventor 赵洪武王海屿
Owner PKU HEALTHCARE CORP LTD
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