Method for extracting artemisine by enriched supercritical fluid
A technology of supercritical fluid and artemisinin, which is applied in organic chemical methods, chemical instruments and methods, pharmaceutical formulations, etc., can solve the problems that the cost is limited by the content of raw materials, the use of equipment is limited, and the production cost is increased. To achieve the effect of increasing farmers' income, reducing coal consumption and promoting industrial production
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Embodiment 1
[0054] Take Artemisia annua and sieve off the branches, detect the artemisinin content of 0.35%, process 6000kg of raw materials per day, weigh 2000kg in each shift, put it in the pool, add normal water to the material surface, soak overnight, and use a mobile microwave generator the next day Radiation once, the power of the microwave generator is 400w, the radiation frequency is 2450MHZ, the water temperature will rise during the radiation, the radiation time is limited to the water temperature not exceeding 60°C, generally 120-240s, and then sent together with the soaking water into the agricultural steel mill for grinding Crushed, grind while adding water, put the ground fine material in a pool or a suitable container and let it stand for 1h. Drain the upper layer of water to expose the abrasive to the water surface, and then irradiate it again by the first microwave radiation method. After the second microwave radiation, the abrasive is moved into an electronically controll...
Embodiment 2
[0059] Take the Artemisia annua raw material and sieve out the stems and branches, weigh 2000kg, and the artemisinin content is 0.53% after detection, and follow the operation steps of the above-mentioned Example 1. The finished product is 10048g. The yield of artemisinin is 94.8%. Based on the purchase price of Artemisia annua at 8 yuan / kg, the production cost is 2165 yuan / kg, which is significantly lower than the current production cost of domestic enterprises.
Embodiment 3
[0061] Get 500kg of Artemisia annua after sieving and removing the stems. After testing, the content of artemisinin is 0.75%. According to the operation steps and methods in Example 1, 14192g of finished products are made, and the yield of artemisinin is 94.6%. The purchase price of raw materials is 8 yuan. In terms of / kg, the production cost is 1548 yuan / kg. If the raw material purchase price is 10 yuan / kg, the production cost is 1829 yuan / kg.
[0062] It can be seen from the above examples that the lower the content of artemisinin in the raw material, the higher the production cost, and vice versa. In the past, raw materials were mainly collected from wild Artemisia annua, so they could be bought at a lower price. However, because the best collection season for raw materials of Artemisia annua is not synchronized with the time when the seeds mature and fall, wild seeds are becoming less and less, and natural resources are scarce. In order to meet the demand of the internati...
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