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Method for improving conversion rate of oil soluble unsaturated lipids into water-soluble lipids

An unsaturated and water-soluble technology, applied in chemical instruments and methods, liposome delivery, edible oil/fat, etc., can solve problems such as reducing the safety and stability of oil-soluble fatty acids, damaging harmful substances, and stimulating the human body. To achieve the effect of increasing absorption, reducing toxicity, and promoting absorption in the body

Inactive Publication Date: 2007-04-04
DONGBU HANNONG CHEMICAL CO
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  • Summary
  • Abstract
  • Description
  • Claims
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Problems solved by technology

In addition, although the lipoplex prepared according to the above method has better solubility and absorbability than the microencapsulation method, due to the use of basic amino acids, it is different from the above method of salifying oil-soluble lipids with alkali metal salts. same, this method still has the problem of stimulating the human body
Moreover, the above methods have additional disadvantages from the viewpoint of oxidative stability, because unsaturated lipids are oxidized by heat, air and light, and acid is added to unsaturated lipids in order to use them as raw materials for food, drug and cosmetic applications. Conversion of lipids to neutral or slightly acidic formulations, which results in breakdown of unsaturated lipids
In addition, the above method has a disadvantage that it cannot completely dissolve water and oil at the molecular level to react with each other, so this leads to the reaction by slowly adding the oil to the aqueous solution in which the basic amino acid is completely dissolved at a constant stirring rate of 2000 rpm. soluble fatty acids
Therefore, unreacted fatty acids always remain in the reactants to lower the safety and stability of oil-soluble fatty acids, thus resulting in harmful substances that impair the quality of final products in large-scale production

Method used

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  • Method for improving conversion rate of oil soluble unsaturated lipids into water-soluble lipids
  • Method for improving conversion rate of oil soluble unsaturated lipids into water-soluble lipids

Examples

Experimental program
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Effect test

Embodiment approach 1

[0042] Embodiment 1: Method for preparing water-soluble lipoplexes from fatty acids using catalysts

[0043] 1. Preparation of Conjugated Linoleic Acid-Chloride Derivatives

[0044] 100 g of conjugated linoleic acid (80%) was added to 50 ml of pyridine for complete dissolution, and 50 ml of thionyl chloride was added to the resulting solution by split injection at 4°C. If thionyl chloride is not added by split injection, the reaction proceeds rapidly and rancidity of the conjugated linoleic acid cannot be avoided. To the resulting solution was added thionyl chloride by split injection and stirred for about 40 minutes resulting in the formation of crystals. The resulting solution containing these crystals was allowed to stand at room temperature for about two hours, and then filtered to obtain the conjugated linoleic acid-chloride derivative in the form of crystals.

[0045] 2. Preparation of Glycine-Conjugated Linoleic Acid Complex

[0046] 100 g of conjugated linoleic acid...

Embodiment approach 2

[0048] Embodiment 2: Method for preparing water-soluble lipoplexes from fatty acids using catalysts

[0049] 1. Preparation of DHA-chloride derivatives

[0050] DHA was substituted for conjugated linoleic acid in the same manner as in Step 1 of Embodiment 1 to obtain a DHA-chloride derivative in the form of crystals.

[0051] 2. Preparation of Lysine-DHA Complex

[0052] In step 2 of embodiment 1, glycine is replaced by lysine, and 3 ml instead of 5 ml of pyridine and thionyl chloride are added to the resulting solution in the same manner as in step 2 of embodiment 1 in a ratio of 1:1 to form DHA-chloride derivative, thus collecting 139 g of water-soluble complex.

[0053] The water-soluble complex obtained in the above steps was detected with an infrared analyzer, and the results are shown in Figure 1.

[0054] As shown in Figure 1, the carboxylate ion (COO - ) peak is shown at 1560cm -1 and 1395cm -1 .

Embodiment approach 3

[0055] Embodiment 3: Another method of preparing water-soluble lipoplexes from fatty acids using emulsifiers

[0056] Stir 200 mg of conjugated linoleic acid and 1 L of water at a stirring rate of 5,000 rpm, keep the temperature at 4° C., then add 2.0% by weight of lecithin and 2.0% by weight of sucrose fatty acid ester to the resulting solution based on the total weight of the solution. and 0.05% by weight of ascorbic acid emulsifier to emulsify. Then, a mixed powder of 100 g of glycine and 100 g of lysine was slowly added to the reactant, and the reaction conditions of 4° C. and 5,000 rpm were maintained until the reactant became homogeneous. At the point where the resulting solution became clear, the reaction was terminated. As a result, 393 g of a water-soluble lipoplex was obtained using a freeze dryer.

[0057] The water-soluble complex obtained in the above process was detected with an infrared analyzer, and the results are shown in FIG. 1 .

[0058] As shown in Figu...

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Abstract

Disclosed relates to a method for improving a conversion rate of oil soluble unsaturated lipids into water-soluble lipids and, more particularly, to a method for improving a conversion rate of oil soluble unsaturated lipids into water-soluble lipids that forms an unsaturated lipid-chloride derivative having an increased reaction activity by using a pyridine-thionyl chloride as a catalyst, not directly causing a reaction between the unsaturated lipids and amino acids, or that applies an emulsifier to cause a reaction between the unsaturated lipids and amino acids so as to minimize the size of lipid particles to a nano-size of less than 50nm, thus improving the reaction conversion rate to more than 99%.

Description

technical field [0001] The present invention relates to a method for improving the conversion rate of oil-soluble unsaturated lipids to water-soluble lipids. Background technique [0002] Unsaturated lipids that have basic functions such as anti-cancer, anti-inflammatory (atopic skin disease), anti-obesity, prevention of dementia, improvement of vision, and treatment of cardiovascular diseases exist in the form of water-soluble lipoproteins in the human body. That is, unsaturated lipids consist of a mixture of lipids and proteins or amino acids. In these compositions, if the amount of low-density lipoprotein and neutral lipid increases, various diseases such as cardiovascular disease can occur. [0003] Therefore, in order to prevent and treat these diseases, various studies aimed at ingesting high-purity unsaturated fatty acids have become active and have achieved desirable results. [0004] However, since unsaturated fatty acids exist in the form of oil-soluble lipids an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127A61K8/02A23L1/39A23D7/00A23D9/00A23L23/00
CPCC07C51/412C11C3/00C07C57/03C07C57/12B82B3/00
Inventor 李成权成淳基金成洙
Owner DONGBU HANNONG CHEMICAL CO
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