Oral preparation containing cephradine and its making method

A technology of cephradine and its preparation, which is applied in the field of therapeutic drugs and its preparation, can solve the problems of slow absorption, low blood drug concentration, long time to reach effective blood drug concentration, etc., and achieve the effect of convenient administration and fast onset of action

Inactive Publication Date: 2007-04-04
刘凤鸣
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In view of the slow oral absorption of tablets, etc., the drug is diluted in the blood through systemic distribution after entering the blood, so that the blood drug concentration of the drug in the lesion is lower, and the time to reach the effective blood drug concentration in the lesion is also longer. Affect its effective antibacterial potency

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Embodiment 1-cephradine candy

[0054] Prescription: cephradine 125g, sucrose 853g, citric acid 10g, food coloring-40 0.1g, mannitol 10g, carbomer 934P 2g, preparation amount 1000 tablets.

[0055] Method: Prepare 125g of cephradine, 10g of citric acid, 0.1g of food coloring-40, 10g of mannitol, and 2g of carbomer 934P, grind and pass through a 20-mesh sieve. Take 853 grams of sucrose, heat to 140°C to melt, cool to 85°C, add the sieved mixture, stir rapidly for 10 minutes, put it on a product forming machine and extrude, each lozenge weighs 1 gram. Then measure the disintegration time limit of cephradine candy in 37 ℃ of 900ml waters and the dissolution rate when disintegrating completely.

[0056] Results: The disintegration time limit is 8-15 minutes, and the dissolution rate when completely disintegrated is 85%-92%.

Embodiment 2

[0057] Embodiment 2-low sugar cephradine candy (1)

[0058] Prescription: cephradine 125g, sucrose 203g, fructooligosaccharides 300g, xylitol 300g, inulin 50g, citric acid 10g, food coloring-40 0.1g, mannitol 10g, carbomer 934P 2g, preparation dose 1000 tablets.

[0059] Method: Prepare 125g of cephradine, 10g of citric acid, 0.1g of food coloring-40, 10g of mannitol, and 2g of carbomer 934P, grind and pass through a 20-mesh sieve. Take 203g of sucrose, 300g of fructooligosaccharides, 300g of xylitol, and 50g of inulin, mix them, heat to 140°C to melt, cool to 85°C, add 125g of cephradine after sieving, stir rapidly for 10 minutes, put on the product forming machine and extrude Pressed into shape, each lozenge weighs 1 gram. Then measure the disintegration time limit of cephradine candy in 37 ℃ of 900ml waters and the dissolution rate when disintegrating completely.

[0060] Results: The disintegration time limit was 6-13 minutes, and the dissolution rate was 86%-91% when co...

Embodiment 3

[0061] Embodiment 3-low sugar cefradine buccal tablet (1)

[0062] Prescription: cephradine 125g, gelatin 240g, glycerin 60g, water 60g, fructooligosaccharides 133g, xylitol 300g, inulin 50g, citric acid 10g, food coloring-40 0.1g, mannitol 10g, magnesium stearate 10g, calorie Bohm 934P 2g, the dosage is 1000 tablets.

[0063] Method: prepare gelatin 240g, glycerin 60g, water 60g mixed matrix, dry, then add cephradine 125g, fructo-oligosaccharide 133g, xylitol 300g, inulin 50g, citric acid 10g, food coloring-400.1g, mannitol 10g, carboxylate Bohm 934P 2g mixture, ground, passed through a 20-mesh sieve, granulated with ethanol and water, dried at 60°C, then added with 10 grams of magnesium stearate, mixed evenly, placed on a tablet machine and extruded to shape, each buccal tablet weight 1 g. Then measure the disintegration time limit of cephradine buccal tablet in 37 ℃ of 900ml waters and the dissolution rate when completely disintegrating.

[0064] Results: The disintegrat...

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Abstract

An orally absorbed medicine in the form of buccal lozenge, sweets, or dripping pill dissolved by saliva features that it contains cefradine. Its preparing process is also disclosed.

Description

[0001] [Technical Field] The present invention relates to a therapeutic drug and its preparation method, especially an oral preparation containing cephradine and its preparation method. [Background technique] [0002] Pharyngitis is the most common disease that plagues the lives of modern people. It is a diffuse inflammation of the pharyngeal mucosa, submucosal tissue and lymphoid tissue, and is often a part of upper respiratory tract infection. Clinically divided into acute and chronic two. Acute pharyngitis mostly occurs at the turn of autumn and winter and winter and spring. Lesions often spread to the entire pharyngeal cavity, but can also be limited to one place. It can be caused by viruses, bacteria, physical and chemical factors, high temperature, dust, smoke mold, irritating gases, etc. Bacterial infections were dominated by Gram-positive cocci such as Streptococcus, Staphylococcus and Diplococcus pneumoniae. Among them, those caused by group A streptococcus are the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K9/48A61K31/545A61P31/04
Inventor 刘凤鸣
Owner 刘凤鸣
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