Ginseng saponin drop balls and making method thereof

A technology of saponins from ginseng stems and leaves, ginseng stems and leaves, applied in the direction of pill delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problem of no obvious enhancement of reactivity, and achieve improved bioavailability, dissolution and absorption Accelerated, lightweight effect

Inactive Publication Date: 2007-04-04
刘凤鸣
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

(3) Effects on lymphocyte transformation: Ginsenosides have a significant enhancement effect on the lymphocyte transformation stimulated by bacterial lipopolysaccharide and concanavalin A, but have no obvious enhancement effect on the reactivity stimulated by phytohemagglutinin

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The preparation of embodiment 1-ginseng stem and leaf saponin dripping pills (1)

[0033] Method: take 0.1 g of polyethylene glycol 2000, 13 g of polyethylene glycol 4000, 23.5 g of polyethylene glycol 6000, 0.1 g of polyethylene glycol 8000, 0.1 g of polyethylene glycol 10000, polyoxyl stearate 40 Ester 1g, Beta Cyclodextrin 0.5g, Poloxamer 0.5g, Carboxymethyl Starch Sodium 0.5g, Stearic Acid 0.1g, Sodium Stearate 0.1g, Glycerin Gelatin 0.1g, Monostearic Acid Glyceride 0.1 g, shellac 0.1 g, polyoxyethylene monostearate 0.1 g, polyether 0.1 g, mix well, then add ginseng stem and leaf saponin raw material powder 10 g, stir well and mix evenly, use electric heating Heat the prepared mixture of raw and auxiliary materials to a molten state, use a self-made special dropping pill machine, adjust the temperature of the dripper and keep it at 85°C (error <2%); use methyl silicone oil as a condensing agent, adjust The refrigeration control system of the machine keeps the tempe...

Embodiment 2

[0035] The preparation of embodiment 2-ginseng stem and leaf saponin dripping pills (2)

[0036] Method: Take 10 grams of polyethylene glycol 4000, 20 grams of polyethylene glycol 6000, 3 grams of polyoxyl 40 stearate, 6 grams of beta cyclodextrin, and 1 gram of glyceryl monostearate, and mix well , then add 10 grams of ginseng stem and leaf saponin raw material powder, fully stir and mix evenly, heat the prepared raw and auxiliary material mixture to a molten state by means of electric heating, and use a self-made special dropping pill machine to adjust the dripper temperature and make it Keep it at 85°C (error<2%); use methyl silicone oil as the condensing agent, adjust the refrigeration control system of the dropping pill machine to keep the temperature of the condensing agent at 20→-5°C (error<5%), and then prepare as before The method given by the technique is dripped, and after shrinkage molding, take it out, remove the surface condensing agent, dry, and make a drop pill...

Embodiment 3

[0038] The preparation of embodiment 3-ginseng stem and leaf saponin dripping pills (3)

[0039] Method: Take 11 grams of polyethylene glycol 4000 and 29 grams of polyethylene glycol 6000, and mix them evenly, then add 10 grams of ginseng stem and leaf saponin raw material powder, stir and mix evenly, and heat the prepared raw materials The mixture is heated to a molten state, and a self-made special pilling machine is used to adjust the dripper temperature and keep it at 85°C (error <2%); using methyl silicone oil as a condensing agent, adjust the refrigeration control system of the dropping pill machine to The temperature of the condensing agent is kept at 20→-5°C (error <5%), and then dropwise according to the method given in the previous preparation process, take it out after shrinkage molding, remove the surface condensing agent, dry, and make a pellet weighing 50mg Contain the drop pill of medicine 10mg / grain, then carry out the mensuration of roundness rate (%), dissol...

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PUM

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Abstract

A dripping pill of ginsenoside is prepared from ginsenoside through proportional adding polyoxyvinyl monostearate, mixing, heating for fusing, stirring, and dripping in condensing liquid.

Description

[0001] [Technical field] The present invention relates to a kind of therapeutic medicine and its preparation method, especially ginseng saponin dripping pill and its preparation method. [Background technique] [0002] Dropping pills refer to preparations made by heating, melting and mixing solid or liquid medicines and substrates, then dropping them into immiscible condensate, and condensation and shrinkage. Because the drug is dispersed in extremely fine particles, colloidally dispersed in the solution, and becomes a rapidly dissolving amorphous mixture, it can effectively improve the oral bioavailability of the drug. In 1971, the rue oil dripping pills that went on the market in my country made the dripping pills truly an effective medicinal dosage form. Dropping pills can be used internally, externally and locally, and can also be made into sustained-release preparations. They have played and continue to play an important role in the field of pharmaceutical preparations in ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A61K31/704A61K9/20A61K47/14A61K47/34A61K47/36A61K47/40A61K47/42A61P25/20A61P11/14A61P1/14A61K47/10
Inventor 刘凤鸣
Owner 刘凤鸣
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