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Effervescence tablet of Glucurolactone, and preparation method

A technology of glucuronolactone and effervescent tablets, which is applied in the field of medicine, can solve problems such as inconvenient application and inability to use, and achieve the effects of avoiding adverse reactions, fast onset of action, and easy demoulding

Inactive Publication Date: 2007-05-09
JIANGSU TASLY DIYI PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Glucuronolactone injection, especially intravenous injection, must be carried out in hospitals and clinics under the operation of medical staff. It is very inconvenient to apply, and it cannot be used on the road, and injection, especially intravenous injection, is in the process of preparation. very strict

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Prescription (1000 tablets):

[0033] Glucuron lactone 0.20kg

[0034] Anhydrous citric acid 0.60kg

[0035] Sodium bicarbonate 0.24kg

[0036] Preparation method: mix 0.2kg glucuronolactone, 0.60kg anhydrous citric acid, and 0.24kg sodium bicarbonate in a container for 30 minutes, transfer to a tablet press equipped with a 5 / 4-inch flat punch, and press 3 / 8-inch Grind and pass through a 16-mesh sieve, granulate, mix for 5 minutes, and tablet.

Embodiment 2

[0038] Prescription (1000 tablets)

[0039] Glucuron lactone 50g

[0040] Anhydrous citric acid 200g

[0041]Sodium bicarbonate 150g

[0042] Filler dextrin 50g

[0043] Adhesive polyvinylpyrrolidone 7.5g

[0044] Sweetener Glycyrrhizin 15g

[0045] Lubricant calcium stearate 18g

[0046] Flavoring Apple flavoring 10g

[0047] Preparation method: prepare materials according to the amount of each component required above, dry glucuronolactone and anhydrous citric acid respectively at a temperature of 60°C, grind them into powder, pass through a 120-mesh sieve, and put them in the glucuron Ester powder, anhydrous citric acid powder and sweetener glycyrrhizin, corrective agent apple flavoring, mix evenly, while adding binder (in the form of 15% by weight aqueous solution), filler, while passing 12 mesh Sieve, granulate, dry at a temperature of 60°C, pass through an 8-mesh sieve, add sodium bicarbonate, mix evenly, add lubricant calcium stearate, mix evenly, and compress in...

Embodiment 3

[0049] Prescription (1000 tablets)

[0050] Glucuron Lactone 100g

[0051] Anhydrous citric acid 85g

[0052] Potassium bicarbonate 100g

[0053] Binder Glycine 25g

[0054] Sweetener protein sugar 3g

[0055] Lubricant Polyethylene Glycol-4000 7.5g

[0056] Preparation method: prepare materials according to the amount of each component required above, dry glucuronolactone and anhydrous citric acid respectively at a temperature of 60°C, grind them into powder, pass through a 100-mesh sieve, and put glucuronide in the glucuron Ester powder, anhydrous citric acid powder and sweetener protein sugar, mix evenly, while adding the binder glycine, pass through a 16-mesh sieve, granulate, dry at 60°C, pass through a 10-mesh sieve, add Alkaline compound potassium bicarbonate, mix evenly, add lubricant polyethylene glycol-4000 (molecular weight), mix evenly, tabletting, after the produced glucuronolactone effervescent tablet is dissolved in water, the resulting solution The pH val...

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PUM

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Abstract

An effervescent tablet of glucuronolactone for protecting liver contains glucuronolactone, pharmacologically acceptable acid-base pairs, additive, adhesive, lubricant, sweetening agent and flavouring. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to the field of medicine, in particular to an effervescent tablet containing glucuronolactone and a preparation method thereof. Background technique [0002] Glucurolactone was synthesized by Stacey in 1939, and its chemical structure was determined by Stanek in 1963. my country started production in 1959. Other names are Tylenol, Glucuronolactone, Glucuronate, Glucurone, Guronsan, Glycurone. The raw material glucuronolactone is white crystal or crystalline powder; odorless, slightly bitter taste, the color gradually darkens when exposed to light. Unstable in nature, easily soluble in water, slightly soluble in ethanol, slightly soluble in methanol. [0003] Glucuron lactone is a hepatoprotective drug that enhances the detoxification function of the liver. When liver cells are damaged, the detoxification function of the liver decreases, and glucuronolactone enters the body under the action of enzymes and becomes glucuronic aci...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365A61K9/20A61K9/46A61P1/16A61P31/12
Inventor 张广明王国成
Owner JIANGSU TASLY DIYI PHARMA CO LTD
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