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Emulsion spray drying method for preparing ultrasound microbubble contrast agent in batch

An ultrasonic microbubble and contrast agent technology, applied in echo/ultrasonic imaging agent and other directions, can solve the problem of not being able to meet industrialized mass production, and achieve the effect of stable performance and good imaging effect.

Inactive Publication Date: 2007-05-09
郑元义 +1
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  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the preparation technology of ultrasonic microbubble contrast agent in China mainly adopts the preparation technology of acoustic vibration method, but the research of ultrasonic microbubble preparation using this technology is still limited in the laboratory, mainly because the preparation technology of ultrasonic microbubble method cannot meet the requirements of industrialization. mass production requirements

Method used

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  • Emulsion spray drying method for preparing ultrasound microbubble contrast agent in batch
  • Emulsion spray drying method for preparing ultrasound microbubble contrast agent in batch
  • Emulsion spray drying method for preparing ultrasound microbubble contrast agent in batch

Examples

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Embodiment 1

[0021] Embodiment 1: Preparation of liposome ultrasonic microbubble contrast agent

[0022] Reagents: Phosphatidylcholine, perfluorohexane, brosham 188, and hydroxyethyl starch were all purchased from Chongqing Pharmaceutical Company.

[0023] Equipment: high-pressure homogenizer, agitator, spray dryer, blood cell counter, etc. are conventional equipment in this field.

[0024] Method: Dissolve 3g of phosphatidylcholine and 0.8g of boroxamer 188 in 250g of double distilled water, add 18ml of perfluorohexane liquid while stirring to obtain liquid fluorocarbon lipid colostrum, and pass the colostrum through high pressure The homogenizer makes a homogeneous emulsion. After mixing the emulsion with an equal amount of physiological saline solution containing 8% hydroxyethyl starch, the liposome microbubbles are prepared by spray drying. After the microbubbles were placed in a vacuum environment (pressure lower than 2torr) for about 1 hour, a mixed gas of fluorocarbon and nitrogen...

Embodiment 2

[0025] Embodiment 2: Preparation of carbohydrate ultrasonic microbubble contrast agent

[0026] Reagents: sugar esters, perfluorohexane, polyether, and hydroxyethyl starch were purchased from Chongqing Pharmaceutical Company.

[0027] Equipment: high-pressure homogenizer, agitator, spray dryer, blood cell counter, etc. are common equipment in this field.

[0028] Method: Dissolve 13g sugar ester in 1.5L double-distilled water, add 100ml perfluorohexane liquid while stirring to obtain liquid fluorocarbon colostrum, and pass the colostrum through a high-pressure homogenizer to obtain a uniform emulsion. Then the emulsion is mixed with an equal amount of physiological saline solution containing 8% hydroxyethyl starch, and the liposome microbubbles are prepared by a spray-drying method. After the microbubbles were placed in a vacuum environment (pressure lower than 2torr) for about 1 hour, a mixed gas of fluorocarbon and nitrogen was introduced until the air pressure was balanced...

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Abstract

A process for preparing the ultrasonic microvesicle contrast medium by O / W emulsified solvent evaporating method and spray drying method includes such steps as dissolving ester in water, stirring while adding perfluorohexane liquid, homogenizing, mixing it with a physiocompatible solution containing hydroxyethyl starch, spray drying to obtain liposome microvesicles, and loading them in a vacuum environment while filling mixed F-C-N gas for disinfecting.

Description

technical field [0001] The invention relates to a method for preparing an ultrasonic microbubble contrast agent, in particular to a method for batch-preparing an ultrasonic microbubble contrast agent by adopting an O / W emulsification solvent evaporation method and a spray drying method. Background technique [0002] Ultrasonic microbubble contrast agent, as a new type of acoustic contrast agent, has played a huge role in the ultrasound imaging of organs and tissues. With the development of ultrasonic technology and the improvement of contrast agent preparation technology, ultrasonic microbubbles will have a broader application prospect. [0003] At present, the preparation technology of ultrasonic microbubble contrast agent in China mainly adopts the preparation technology of acoustic vibration method, but the research of ultrasonic microbubble preparation using this technology is still limited in the laboratory, mainly because the preparation technology of ultrasonic microb...

Claims

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Application Information

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IPC IPC(8): A61K49/22
Inventor 郑元义王志刚冉海涛许川山张群霞凌智瑜杨春江李兴开
Owner 郑元义
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