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Method for preparing colon targeted pill of florfenicol used for poultry and livestock

A florfenicol and colon-targeting technology, which is applied in pill delivery, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems that have not yet been retrieved for invention patents, and achieve good therapeutic effects

Inactive Publication Date: 2007-05-30
TIANJIN RINGPU BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] No patents have been retrieved for the invention of this drug in the field of veterinary drug targeted preparations

Method used

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Embodiment 1: the preparation method of florfenicol colon targeting pill

[0041] 1. Drugs, excipients and reagents

[0042] Florfenicol raw material, Eudragit S100, triethyl citrate, blank pellets 40 mesh, HPMC 15MPa.S, 10MPa.S, 5MPa.S, 95% ethanol.

[0043] 2. Instruments and equipment

[0044] EPL-1 fluidized bed, 78HW-1 magnetic stirrer, J-11 stirrer

[0045] 3. Preparation method

[0046] 1. Place 900 g of blank pellets in a fluidized bed, and coat the drug layer, retardation layer, time lag layer and pH-sensitive film in sequence according to the following methods and processes.

[0047] (1) Coating of the main drug

[0048] Preparation of coating solution: Dissolve 100 g of Florfenicol in 1000 ml of 50% ethanol.

[0049] Coating conditions:

[0050] Material temperature: 40°C Air outlet temperature: 40°C Liquid supply hose inner diameter: 2mm

[0051] Air inlet temperature: 48°C Liquid supply speed: 20r / min Spray gun diameter: 1.2mm

[0052] Induced air flo...

Embodiment 2

[0073] Embodiment 2: use medicine of the present invention to treat livestock and poultry to chloramphenicol-resistant Escherichia coli, Salmonella, Klebsiella effective, absorption is fast after oral administration, widely distributed, blood drug maintenance concentration time is long, in livestock and poultry colon Parts can effectively exert the curative effect of drugs, and have good curative effect on respiratory tract infection, mastitis of cattle, pleuropneumonia, yellow scour, pullorum of pigs, colibacillosis and pasteurellosis of chickens. The way of administration is mixed material administration, 228g-456g per ton of feed, 3-5 days as a course of treatment, and the cure rate can reach more than 90%.

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Abstract

The invention discloses a fluorobenzenenicore colon targeting pill of flock, which comprises the following parts: fluorobenzenenicore as drug layer, 8% ethol as retarding layer, 2% HPMC as time lag layer and 15% S100 as sensitive film. The invention can release drug directionally, which treats local and whole body infection.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine, and relates to a florfenicol colon-targeted pill for treating diseases caused by bacterial infection in livestock and poultry. Background technique [0002] With the continuous improvement of the scale and intensification of livestock and poultry breeding, various problems in breeding also follow. Some diseases caused by bacteria and mycoplasma often occur in livestock and poultry. For the above-mentioned situation, the current method of treating this type of disease is mainly to control this type of disease with antibiotics. In terms of human medicine, there is a colon-targeted drug delivery system (OCDDS), which is a targeted preparation that releases drugs in the colon. Oral colon-targeted drug delivery system is a research hotspot recently. It is a new preparation for localized drug release in the colon through oral administration to achieve local or systemic treatment. The colo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/165A61K9/20A61P31/04
Inventor 李旭东鲍恩东苏建东
Owner TIANJIN RINGPU BIO TECH
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