Biodegradable nanometer medicine capsule with CT trace effect and its prepn process

A biodegradable and nano-drug technology, applied in the direction of medical preparations containing active ingredients, capsule delivery, pharmaceutical formulations, etc., can solve the problems of not being discovered, and achieve high drug loading, low production equipment requirements, and simple processes Effect

Inactive Publication Date: 2007-06-06
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are still some lesions that cannot be found in non-enhanced scans. T

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Take 3ml of 3.5% (w / v) aqueous solution of polyvinyl alcohol PVA as the inner water phase (ie, dispersion system A), and disperse 30mg ovalbumin and 0.8mg amnipague CT contrast agent in water; organic The phase (ie dispersion B) was 6 ml dichloromethane dissolved with 2.5% (w / v) PLGA; the outer aqueous phase (ie dispersion C) was 54 ml aqueous solution of 0.4% (w / v) PVA dissolved with stirring. Add the inner water phase to the organic phase and disperse it uniformly in a homogenizer (9500rpm), then add it to the outer water phase to disperse, under the conditions of a temperature of 23°C and a pressure of 1.01 × 105 Pa, fully Stir until the organic phase is completely evaporated, PLGA is precipitated and solidified into a sphere, and ovalbumin and amnipague CT contrast agent are encapsulated in it to form drug-loaded nanocapsules with a core / shell structure.

Embodiment 2

[0049] Take 3ml of 4.5% (w / v) polyvinyl alcohol PVA aqueous solution as the inner water phase, disperse 45 mg of doxorubicin and 1.2 mg of amnipague CT contrast agent in water; the organic phase is dissolved in 6 % (w / v) PLA in 6 ml of ethyl acetate; the outer aqueous phase is 65 ml of 0.5% (w / v) PVA in water dissolved by stirring. Add the inner water phase to the organic phase and disperse it uniformly in a disperser (9500rpm), and then add it to the outer water phase to disperse at a temperature of 26°C and a pressure of 1.01×10 5 The organic phase was removed by stirring and evaporating for about 180 minutes under the conditions of palladium, PLA precipitated and solidified into spheres, and doxorubicin and amnipague were encapsulated inside to form drug-loaded nanocapsules with core / shell structure.

Embodiment 3

[0051] Take 6ml of 5% (w / v) sodium dodecyl sulfonate aqueous solution as the inner water phase, disperse 30 mg of paclitaxel and 1.5 mg of amnipague in water; the organic phase is dissolved in 10% ( w / v) PLGA in 6 ml dichloromethane; the outer aqueous phase is 0.4% (w / v) PVA 54 ml in water dissolved by stirring. Add the inner water phase to the organic phase and disperse it uniformly in a mixer (9500rpm), then add it to the outer water phase to disperse at a temperature of 26°C and a pressure of 1.01×10 5 Paclitaxel and amnipague were encapsulated inside to form drug-loaded nanocapsules with core / shell structure.

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Abstract

The present invention is biodegradable nanometer medicine capsule with CT trace effect and its preparation process. The nanometer level capsule is a core-shell structure and has shell layer of biodegradable polymer material and core with distributed CT contrast agent and hydrophilic or water soluble medicine. The CT contrast agent is ionic or non-ionic iodine contrast agent, the ionic iodine contrast agent is meglumine iodipamide or meglumine diatrizoate, and the non-ionic iodine contrast agent is amnipague, utravist or iodized oil injection. The capsule has several functions, high medicine carrying amount, targeting and controllable release, capacity of in vitro monitoring and other features. The present invention provides one effective medicine carrier for raising curative effect, monitoring the in vivo medicine distribution and developing new medicine.

Description

technical field [0001] The invention relates to a capsule, in particular to a biodegradable multi-effect nanocapsule with CT tracer effect and real-time monitoring of drugs in vitro and a preparation method thereof. Background technique [0002] As we all know, the research of nano-drugs is a new direction with great vitality in drug research. Drugs are mainly loaded into nano-drug carriers by methods such as encapsulation and adsorption. Nanotechnology is used in drug research, and has been carried out for many years abroad. Microspheres. Since the particle size of nano-drugs is smaller than the capillary diameter (6-8 μm), they can easily enter various tissues and organs of the human body for controlled release, which greatly improves the bioavailability of drugs. It also has many advantages that conventional drugs do not have: slow-release drugs, changing the half-life of drugs in the body, and prolonging the action time of drugs; after being made into targeted drugs, t...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K45/06A61K49/00
Inventor 任山陈卫丰崔秀环洪澜冉丕鑫刘志刚李立曾木圣
Owner SUN YAT SEN UNIV
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