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Use and production for mulberry leaf in treatment of diabetes

A kind of mulberry leaf extract and mulberry leaf technology, which is applied in the direction of medical formula, drug combination, metabolic diseases, etc., can solve the problems of no involvement, etc., and achieve the effect of easy operation, simple preparation process and low cost

Inactive Publication Date: 2007-06-20
TIANJIN ZHONGXIN PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The Chinese patent with the application number CN 01113191.8 discloses "Preparation method and application of traditional Chinese medicine extract with α-glucosidase inhibitory activity", which involves the preparation of total biological Alkali, but it does not involve the application of total alkaloids and total flavonoids of mulberry leaves as extracts of effective fractions

Method used

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  • Use and production for mulberry leaf in treatment of diabetes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] 10kg of mulberry leaves, pulverized, reflux extracted with 30% ethanol for 3 times, 50L each time; combine the 30% ethanol extracts, concentrate under reduced pressure to 10L, the specific gravity is 1.18, add 20L of 95% ethanol to make the ethanol concentration reach about 60% , stand still for 24 hours, filter out the precipitate; after the supernatant is concentrated to remove alcohol, add water to dilute to 100L, pass through the D101 resin column, the column volume is 10L, wash 30L with water after loading the sample, and combine the effluent and washing liquid; the D101 resin is then used for 60 Elute with 50L of % ethanol, concentrate the 60% ethanol eluate and dry under reduced pressure to obtain 130g of total flavonoids (57% content); add hydrochloric acid to the effluent and washing liquid to adjust the pH to 4, and pass through 10L of 001×7 polystyrene sulfonate Acid-hydrogen type cation exchange resin, washed with water until colorless, eluted with 0.5N ammon...

Embodiment 2

[0039]5kg of mulberry leaves, pulverized, refluxed with 50% ethanol and extracted 3 times, 10L each time; combined the 50% ethanol extracts, concentrated under reduced pressure to 10L, the specific gravity was 1.17, added 7L of 95% ethanol to make the ethanol concentration reach about 70% , stand still for 24 hours, filter out the precipitate; after the supernatant is concentrated to remove alcohol, add water to dilute to 100L, pass through the AB8 resin column, the column volume is 5L, wash 20L with water after loading the sample, and combine the effluent and washing liquid; the AB8 resin is then used for 70 Elute with 30L of % ethanol, concentrate the eluate with 70% ethanol and dry under reduced pressure to obtain 70g of total flavonoids (62.5% content); after adding hydrochloric acid to the effluent and washing liquid to adjust the pH to 5, pass through 6L of 001X14.5 polystyrene sulfonate Acid-hydrogen type cation exchange resin, after washing to colorless, 40L was eluted ...

Embodiment 3

[0041] 1 kg of mulberry leaves, crushed, refluxed with 70% ethanol for 3 times, 5L each time; combined 70% ethanol extracts, concentrated under reduced pressure to 1.5L, with a specific gravity of 1.16, added flocculant chitosan, stood for 24h, filtered Precipitate; after the supernatant is concentrated to remove alcohol, dilute with water to 10L, pass through the HP20 resin column, the column volume is 2L, wash 5L with water after loading the sample, combine the effluent and washing liquid; HP20 resin is then eluted with 60% ethanol 5L, 60 Concentrate the % ethanol eluate and dry it under reduced pressure to obtain 11 g of total flavonoids; add hydrochloric acid to the effluent and washing liquid to adjust the pH to 4, pass through 10 L of 001×7 polystyrene sulfonate hydrogen cation exchange resin, wash with water until colorless, Elute 8L with 0.5N ammonia water, concentrate and dry the ammonia water eluent to obtain 5g of total alkaloids (content: 73%); mix total flavonoids ...

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Abstract

An extract of mulberry leaf contains general alkaloid and general flavone, and is prepared through extracting, removing impurities, concentrating, eluting, drying and mixing. It can be used to prepare the medicines for preventing and treating diabetes and its complications.

Description

technical field [0001] The invention relates to a mulberry leaf extract and its application and preparation method in the preparation of medicines for treating diabetes and its complications, belonging to the field of traditional Chinese medicine modernization. Background technique [0002] Diabetes is a common endocrine disease, which is mainly caused by genetic factors and environmental factors such as poor eating habits (overeating, refined food, etc.), lack of exercise, obesity and stress reactions. With the aging of the world's population, diabetes has become a common and frequently-occurring disease, and the incidence rate is showing a significant upward trend. [0003] Diabetes is a syndrome composed of chronic hyperglycemia and complications caused by genetic, environmental, immune and other factors with obvious heterogeneity. It is mainly divided into type I and type II. In type I diabetes (insulin-dependent diabetes), the pancreas produces little or no insulin; in...

Claims

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Application Information

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IPC IPC(8): A61K36/605A61P3/10
Inventor 潘勤肖峰孙琳
Owner TIANJIN ZHONGXIN PHARMA GRP CO LTD
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