Tartaric acid metoprolol sustained release capsules and its preparation method

A technology of metoprolol tartrate and sustained-release capsules, which is applied in the field of metoprolol tartrate sustained-release capsules and its preparation, can solve the problems of inconsistency and inconvenience in blood pressure and blood drug concentrations, achieve shortened processing time, simple process, Effects that are easy to manipulate and control

Inactive Publication Date: 2007-07-04
TIANJIN GUOYAO BOHAI BIOMEDICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because the blood concentration of this drug reaches its peak value 1.5 hours after oral administration, and the reduction of blood pressure is not parallel to the blood concentration, so patients need to take it twice a day, which will be very painful for middle-aged and elderly patients and those with limited mobility. inconvenient

Method used

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  • Tartaric acid metoprolol sustained release capsules and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Based on 1000 metoprolol tartrate sustained-release capsules, place 105 g of commercially available hollow ball cores between 25 and 30 meshes in a CF300 granulator, and spray 50% sucrose syrup until the hollow ball cores are fully Wetting; 25g of metoprolol tartrate passing through a 100 mesh sieve, 20g of lactose passing through a 80 mesh sieve and 20g of starch powder crossing a 100 mesh sieve were mixed evenly and added to the above-mentioned granulator for 50 minutes to obtain a smooth surface. Medicine granules, after the main medicine granules are wrapped, continue to spray 50% sucrose syrup, and add 8g of starch to wrap the main medicine protective layer, and then place the wrapped main medicine granules in a vacuum oven at 80°C to dry for 3 hours. Or dry in an ordinary electric drying oven at 80°C for 6 hours; dissolve 10g of acrylic resin sustained-release material EUDRAGIT RS100 with an appropriate amount of 95% ethanol, and add 3g of talcum powder, an auxilia...

Embodiment 2

[0015] Based on 1000 metoprolol tartrate sustained-release capsules, place 105 g of commercially available hollow ball cores between 25 and 30 meshes in a CF300 granulator, and spray 50% sucrose syrup until the hollow ball cores are fully Wetting; 50g of metoprolol tartrate crossing a 100 mesh sieve and 15g of polyethylene glycol 6000 crossing a 80 mesh sieve and 13g of pregelatinized starch powder crossing a 100 mesh sieve are mixed evenly and added to the above-mentioned granulator for processing for 50 After the main drug granule is wrapped, continue to spray 50% sucrose syrup, and add 5g of starch to wrap the main drug protective layer, and then place the wrapped main drug granule in a vacuum at 80°C Dry in a drying oven for 3 hours, or dry in an ordinary electric drying oven at 80°C for 6 hours; dissolve 8g of polyvinylpyrrolidone with an appropriate amount of 95% ethanol and 12g of hydroxypropyl methylcellulose with 5mL of water, and at the same time In addition, add 3 g...

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Abstract

A tartaric acid metoprolol slow release capsules and its preparation. It is prepared by tartaric acid metoprolol, slow release materials and findings in the weight ratio of 25-100:5-20:131-165 to preparing slow-release pellets with different release degree, the slow release materials are one to four of acrylic resin, hydroxypropyl methyl cellulose, ethyl cellulose, phthalate vinegar acid cellulose and polyvinylpyrrolidone; the content of tartaric acid metoprolol in single capsules is 25-100mg. Preparation method uses rolling shaping pill mean. The capsule can maintain balanced and durable effective blood drug concentration in the same dosage and time intervals, or decreases dosage and side effects remaining same drug effect; In particular, it is dispersable agent, it not only can improve the contact area of gastrointestinal tract to making drug absorption completely and the bioavailability higher, and it can get ideal release drugs rate using different pellets combination. In addition, the craft of preparation method used is simple and easy to operating and controlling.

Description

technical field [0001] The invention relates to the field of medicines and preparation thereof, in particular to a metoprolol tartrate slow-release capsule capable of treating hypertension, angina pectoris and hyperthyroidism and a preparation method thereof. Background technique [0002] Hypertension, angina pectoris, and hyperthyroidism are common and frequently-occurring diseases with a high incidence rate. If not treated properly or not treated in time, it may lead to serious complications and endanger the patient's physical and mental health, and even life-threatening. Metoprolol tartrate is an auxiliary drug for the treatment of hypertension, angina pectoris and hyperthyroidism. It is widely used in clinical treatment, especially it has been used as a first-line drug for the treatment of hypertension, but its disadvantage is that the side effects are very obvious. Adverse reactions mainly include symptoms in the cardiovascular system, central nervous system, digestive ...

Claims

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Application Information

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IPC IPC(8): A61K31/138A61K9/52A61P9/10A61P9/12A61P5/16A61J3/07
Inventor 李立柱刘利杨恩久
Owner TIANJIN GUOYAO BOHAI BIOMEDICAL
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