Compositions for preventing or ameliorating multiple risk factor syndromes

Inactive Publication Date: 2004-02-12
KANEKA CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

0023] The present invention has for its object to provide a composition for preventing or ameliorating multiple risk factor syndrome invol

Problems solved by technology

However, these therapeutic regimens are recommended or prescribed to patients by medical institutions, and are not directed to the so-called candidate patients in the reserve.
However, appetite suppressants and inhibitors of digestion and absorption do not positively lower visceral fat, and energy consumption promoters do not specifically lower visceral fat.
Thus, besides the sharply increasing number of diabetics, the number of individuals in the reserve and not on therapy by medical institutions is by far large, and this is a matter of serious concern.
However, these are no more than

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

Preparation of a Licorice Hydrophobic extract-1

[0051] Using a glass vessel, 500 g of licorice powder (Kaneka Sun Spice Co., Ltd.) was steeped in 5 volumes of ethyl acetate and allowed to stand at room temperature, protected against light, for 1 week with occasional stirring. The mixture was filtered through filter paper (ADVANTEC No.2) twice to remove the powder and recover an extract solution. The extract solution was concentrated under reduced pressure to remove the solvent, whereupon 33.91 g of a licorice hydrophobic extract was obtained.

reference example 1

The Glycyrrhizin Content of the Licorice Hydrophobic Extract

[0052] The glycyrrhizin content of the licorice hydrophobic extract prepared in Preparation Example 1 was quantitated by HPLC referring to the method of M. A. Raggi, et al. (Boll. Chim. Farmaceutico., 133, 704-708, 1994). As the analytical column, COSMOSIL 5C18-AR, 4.6.times.250 mm (Nacalai Tesque, Inc.) was used at 40.degree. C. Using acetonitrile:distilled water:acetic acid (35:65:0.5, v / v) as a mobile phase run at a flow rate of 1 ml / min., the peak was detected at 251 nm. Using ammonium glycyrrhizinate (Wako Pure Chemical Industries, Ltd.; food additive test grade) as a glycyrrhizin standard, a calibration curve was constructed over the concentration range of 1 to 20 .mu.g / ml, and an assay was carried out.

[0053] As a result, the amount of glycyrrhizin in 1 mg / ml of the licorice hydrophobic extract was 4 .mu.g / ml, i.e. the glycyrrhizin content of the extract was 0.4%. Since the glycyrrhizin content is generally not less t...

preparation example 2

Preparation of a Licorice Hydrophobic Extract-2

[0065] Using a glass vessel, 300 g of licorice powder (Kaneka Sun Spice Co., Ltd.) was steeped in 10 volumes of lukewarm water (about 40.degree. C.) and stirred, protected against light, overnight (for about 18 hours). The mixture was then filtered through filter paper (ADVANTEC No.2) and the residue obtained was dried (about 60.degree. C.) to recover 265 g of an aqueous extraction residue. This residue was steeped in 5 volumes of ethanol and allowed to stand at room temperature, protected against light, for 1 week with occasional stirring. The mixture was filtered through filter paper (ADVANTEC No.2) twice to remove the powder and recover an extract solution. This extract solution was concentrated under reduced pressure to remove the solvent, whereupon 23.62 g of a licorice hydrophobic extract was obtained.

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PUM

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Abstract

The invention aims at a composition for preventing or ameliorating multiple risk factor syndrome involving visceral fat-type obesity, diabetes mellitus, hyperlipemia and hypertension, which comprises at least one member selected from the group consisting of a licorice hydrophobic extract, a turmeric extract, a clove extract, and a cinnamon extract.

Description

[0001] 1. Technical Field[0002] The present invention relates to a composition for preventing or ameliorating multiple risk factor syndrome involving visceral fat-type obesity, diabetes mellitus, hyperlipemia and hypertension.[0003] 2. Background Art[0004] Lifestyle-related desease arising from deteriorations of living habit such as supernutrition and under exercise is a major social concern today. Lifestyle-related desease involves various states of desease such as obesity, diabetes mellitus, hyperlipemia and hypertension, and these states of desease are gathering considerable attention as multiple risk factor syndrome that maybe an underlying disease of arteriosclerosis. Moreover, this is a matter of concern not only in humans but also in pet animals such as dogs and cats.[0005] Obesity is roughly classified into subcutaneous fat-type obesity resulting from accumulation of subcutaneous fat and visceral fat-type obesity resulting from accumulation of intra-abdominal fat.[0006] Visc...

Claims

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Application Information

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IPC IPC(8): A21D2/36A23L7/109A23L27/10A23L27/60A23L33/115A23L33/15A61K8/97A61K33/06A61K36/00A61K36/48A61K36/484A61K36/54A61K36/61A61K36/9066A61P3/04A61P3/06A61P3/10A61P9/12A61Q19/06
CPCA21D2/36A23L33/175A61K36/48A61K36/54A61K36/61A61K36/9066A61Q19/06A61K8/97A23L33/16A23L33/15A23L33/105A23L33/10A23L27/60A23K50/40A23K20/10Y10S514/909A61K2300/00A61K8/9789A61K8/9794A61P3/10A61P3/04A61P3/06A61P43/00A61P9/12A61K36/236
Inventor MAE, TATSUMASATSUKAGAWA, MISUZUKISHIDA, HIDEYUKIKITANO, MITSUAKIKITAHARA, MIKIONAKAGAWA, KAKU
Owner KANEKA CORP
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