Regulation of mammalian hair growth

a technology of mammalian hair and regulation, applied in the field of topical compositions, can solve the problems of affecting the effect affecting the appearance of full or partial baldness, and human function loss, and achieve the effect of safe and effective amount of skin care actives

Inactive Publication Date: 2005-01-06
THE PROCTER & GAMBLE COMPANY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention relates to a topical skin care composition containing a safe and effective amount of a skin care active comprising agmatine, and its salt; a safe and effective amount of a first additional skin care active selected from the gro...

Problems solved by technology

Wherein hair growth ceases, most of the hair follicles reside in telogen and anagen is not engaged, thus causing the onset of full or partial baldness.
However, that function has been lost in humans, in whom, hair is kept or removed from various parts of the body, essentially for cosmetic reasons.
However, such conventional procedures frequently have drawbacks associated with them.
Shaving, for instance, may cause nicks, cuts, rash and irritation and often leaves an undesirable stubble.
Electrolysis and laser hair removal can keep a treated area free of hair for prol...

Method used

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  • Regulation of mammalian hair growth
  • Regulation of mammalian hair growth
  • Regulation of mammalian hair growth

Examples

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examples

The following examples further describe and demonstrate embodiments within the scope of the present invention. The examples are given solely for the purpose of illustration and are not to be construed as limitations of the present invention, as many variations thereof are possible without departing from the spirit and scope of the invention.

Skin Cream

examples 1-5

A moisturizing skin cream / lotion is prepared by conventional methods from the following components.

Example12345Phase AComponentWaterqsQsqsqsqsGlycerol5.00007.00007.000010.00005.0000phenylbenzimidazole00001.2500sulfonic aciddisodium EDTA0.10000.10000.10000.10000.1000Allantoin0.20000.20000.20000.20000.2000Triethanolamine00000.7500sodium metabisulfite0.10000.20000.10000.10000.1000BHT0.500.500.500.500.50titanium dioxide0.25000.45000.45000.75000.5500Niacinamide002.00003.50002.0000Dexpanthenol0.250.50001.00002.00001.0000palmitoyl-pentapeptide1000.000400.0003C12-C15 alkyl benzoate5.002.50001.50002.50000caprylic / capric1.01.50001.50001.50001.5000triglycerideFarnesol00.50005.00003.00003.0000octyl salicylate00005.0000Octocrylene00001.0000butyl00002.0000methoxydi-benzoylmethanecetyl alcohol0.50000.50000.50000.50000.5000tocopherol acetate00.50000.50000.50000.5000tocopherol sorbate0.5000000.50000.2000sorbitan stearate / 1.00001.00001.00001.00001.0000sucrose cocoatecetearyl glucoside0.50000.50000...

examples 6-8

A moisturizing skin cream / lotion for hand and body skin care is prepared by conventional methods from the following components.

The following examples further describe and demonstrate embodiments within the scope of the present invention. They are given for the purpose of illustration and are not to be construed as limitations of the present invention. Where applicable, ingredients are given in CTFA name. All of the examples are oil-in-water emulsions prepared using conventional formulating techniques. The coated titanium dioxide is incorporated via the oil phase ingredients whereas the nylon particles and interference pigment are added via the aqueous phase.

Example678Component% w / w% w / w% w / wNiacinamide2.04.06.0Retinyl Propionate0.2Panthenol1.02.00.5Polyacrylamide & isoparaffin & laureth-72.02.252.25Glycerine5.03.07.0Allantoin0.20.050.1Aloe vera gel0.050.0750.05Tocopheryl acetate0.750.50.5Cetyl alcohol2.01.01.25Stearyl alcohol2.01.01.25Behenyl alcohol1.01.01.25Dimethicone & dime...

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Abstract

The present invention relates to a topical skin care composition containing a safe and effective amount of a skin care active comprising agmatine, and its salt; a safe and effective amount of a first additional skin care active selected from the group consisting of BHT or BHA, hexamidine, cetyl pyridinium chloride, green tea catechins, phytosterols, ursolic acid, compounds derived from plant extracts, their salts and derivatives; and a dermatologically acceptable carrier for the agmatine composition. The present invention also relates to methods of using such agmatine compositions to regulate hair growth and the condition of mammalian skin. Said methods generally comprise the step of topically applying the composition to the skin of a mammal needing such treatment, a safe and effective amount of such compositions.

Description

TECHNICAL FIELD The present invention relates to topical compositions containing a combination of skin care actives, particularly agmatine and its salts, in combination with other skin care actives such as butylated hydroxytoluene (BHT) and butylated hydroxyanisole (BHA), cetyl pyridinium chloride, hexamidine, phytosterols, compounds derived from plant extracts, green tea catechin compounds, ursolic acid, and free fatty acids. Such compositions are useful for regulating the condition of keratinous tissue, including, but not limited to, regulating mammalian hair growth, preferably inhibiting and / or retarding hair growth and / or reducing shaving frequency. BACKGROUND OF INVENTION As is well-known in the art, normal hair growth occurs by a cycle of activity which involves alternating periods of growth and rest. This cycle is often divided into three main stages which are known as anagen, catagen, and telogen. Anagen is the growth phase of the cycle and may be characterized by penetrat...

Claims

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Application Information

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IPC IPC(8): A61K8/34A61K8/40A61K8/43A61K8/49A61K8/63A61K31/155A61K31/353A61K31/7048A61K36/82A61K45/06A61Q1/02A61Q7/00A61Q7/02A61Q15/00A61Q19/00
CPCA61K8/347A61K8/40A61Q19/00A61Q15/00A61Q7/02A61Q1/02A61K45/06A61K36/82A61K31/7048A61K8/43A61K8/4926A61K8/63A61K31/155A61K31/353A61K2300/00
Inventor OBLONG, JOHN ERICHMCPHAIL, SARA JOHNSONMCARTHUR, SHANNON CHRISTINEBASCOM, CHARLES CARSONEICKHOFF, DAVID JOSEPHMCIVER, JOHN MCMILLAN
Owner THE PROCTER & GAMBLE COMPANY
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