71 results about "Skin tumor" patented technology

The present invention discloses an anti-tumor compound and its preparation method,application, and pharmaceutical compositions. The anti-tumor compound is a 4 - nitro-substituted benzyl group ifosfamide ester prodrug thereof, or pharmaceuticallysalt, or solvate thereof of the structure of formula I. The structure of formula I. The present invention has the following advantage of being used for the treatment or prevention of mammalian tumor-related diseases, such as leukemia, hemangioma, glioma, Kaposi's sarcoma, ovarian cancer, breast cancer, lung cancer, pancreatic cancer, lymphoma, prostate, colon and skin tumors and their complications.

A novel animal model for the treatment of skin tumors is described. In particular, the invention provides transgenic non-human animals comprising a recombinant nucleic acid molecule containing a nucleic acid sequence encoding at least one of the gene products of the early genes of a virus of the Human Papilloma Virus Group B1, in which the animal displays one or more clinical symptoms of a tumor. The transgenic animals can be used to screen anti-tumor agents and to identify the tumorigenic potential of compounds.

The present invention relates to the effect of naturally occurring compounds on tumor development. As an example of proof, we used low; non-toxic doses of three compound e.g. Calcium D-glucarate, a naturally occurring Ca++ salt of D-glucaric acid; Nicotinamide (NA), a naturally occurring vitamin and butyric acid (BA), a naturally occurring saturated short chain fatty acid. 7,12 dimethylbenzanthracene (DMBA), which is a very potent skin carcinogen and is an environmental pollutant, was used for skin tumor development. Experiment was performed upto 30 weeks. All the above-mentioned compounds were used either alone or concomitantly any two or all the three. In the positive control group 100% tumorigenesis was attained in 28 weeks, use of single compound led to the inhibition of DMBA induced tumorigenesis between 33 to 47%, use of two compounds resulted in the 73 to 80% reduction in tumorigenesis but the concomitant use of three compounds resulted into 100% inhibition of tumor development at the end of 30 weeks. This led us to conclude that the concomitant use of Cag, NA and BA in combination of two is useful for preventing skin tumor develoment for a sort or long period of time. But the concomitant use of all the three compounds, as described, exhibited the perfect synergistic effect in preventing the tumor development completely. This strategy should be equally effective in the management of benign and possibly malignant tumor in any organ caused by any mean.

The present invention refers to a method of treating a cancerous or non-cancerous skin lesion of a subject, e.g. a human patient, by epidermal radioisotope therapy, a specialized type of brachytherapy, comprising the steps of (a) defining and marking an area of skin to be treated; (b) covering said area with a protective layer, e.g. a protective film or foil; (c) applying a tailor-made radioactive source by applying a layer of a radioactive source material on said protective layer, such that said area is covered by said material while any area not to be treated is spared; and (d) removing the radioactive source after a predetermined time period of irradiation.

Compositions of human proteins, methods and regimens for reducing the occurrence and growth of skin cancer, including melanoma, are provided. The methods include steps of administering topically on the skin tumor or a skin cancer-free area of compositions containing therapeutically effective amounts of human alkaline phosphatase, transferrin and α1-antitrypsin. In some embodiments, the composition is topically administered and includes all three proteins. Alkaline phosphatase, alone or in combination with transferrin and α1-antitrypsin can also be administered by injection with or without simultaneous or sequential topical administration. Administration of compositions topically and / or by injection can be part of a more complex cancer therapy including chemotherapy, radiotherapy, surgery, and electrochemotherapy.

A magnetic resonance spectroscopy and imaging device and method of use for accurately delineating the lateral extent and depth of a skin tumor. The device includes a radiofrequency tuned circuit with an antenna in the shape of an acupuncture needle that is positionally-controlled using a mechanical actuator to provide high-contrast spatial images of skin tumors with sub-millimeter lateral and depth resolution. The device is used by dermatologists to provide accurate spatial demarcations of skin tumors, which facilitate the complete excision of a tumor in the first pass of the Mohs micrographic surgical procedure. Different sizes and shapes of the needle antenna provide advantages for sensitivity, image resolution, and capabilities to impact treatments. A hollow needle antenna provides for a capability of the inventive device to affect treatment of a skin tumor by injecting a chemical agent while monitoring chemical and spatial aspects of the tumor, and by aspirating cancer tissue to remove the tumor and related chemical treatment agents.

Methods, compositions and products for preventing skin tumor formation or inhibiting development of an existing skin tumor in a subject are described. The methods involve administering to the subject a composition containing an α2 adrenergic receptor agonist, such brimonidine.

ABSTRACT Administration of the isothiocyanate protects against UV light-induced skin carcinogenesis. In particular, topical application or dietary administration of isothiocyanate sulforaphane after exposure to UV radiation provides effective protection against skin tumor formation. Sulforaphane analogs and glucosinolates also can be employed. Lotions useful for suppressing UV light-induced skin carcinogenesis also are provided.

The invention provides compositions and methods for treating skin cancer associated diseases. Specifically, the invention relates to topically administering a signaling pathway inhibitor or a related compound to treat pre-cancerous skin lesions, skin tumors, and their associated diseases or disorders.

The invention discloses a method for detecting seven types of skin tumors for a cellphone, and the method adopts an optimized Inception-v3 classification network for skin tumor images and achieves thedesired effect. The network is also suitable for other dermoscopic image detection, and a skin tumor classification method is proposed, which can detect seven types of skin tumors. The results show that the detection accuracy of the method is up to 92% higher than 75% of human eye recognition, which can effectively assist doctors in diagnosis. The present invention proposes an application development method for the detection of the seven types of skin tumors. The computer vision related knowledge is applied to people's real life, thereby simplifying the process of detecting skin tumors, and enabling doctors to obtain test results in real time simply by simply operating the application.

Compositions of human proteins, methods and regimens for reducing the occurrence and growth of skin cancer, including melanoma, are provided. The methods include steps of administering topically on the skin tumor or a skin cancer-free area of compositions containing therapeutically effective amounts of human alkaline phosphatase, transferrin and α1-antitrypsin. In some embodiments, the composition is topically administered and includes all three proteins. Alkaline phosphatase, alone or in combination with transferrin and α1-antitrypsin can also be administered by injection with or without simultaneous or sequential topical administration. Administration of compositions topically and / or by injection can be part of a more complex cancer therapy including chemotherapy, radiotherapy, surgery, and electrochemotherapy.

The invention relates to a skin tumor resection area calculating method. The method comprises the steps that a skin tumor image is collected in the skin tumor region of a tumor to be resected, and theskin tumor image is acquired; the tumor contour line of the skin tumor image is extracted by a computer; feature points of the tumor contour line are determined, and a feature point set is acquired;the graphic geometric information of the tumor contour line is established; the feature point set of the tumor contour line is triangulated; and the tumor contour area is calculated. According to theskin tumor resection area calculating method, image acquisition is less reliable to the influence of exposure, the shooting angle and the like; the reliability is higher; and the tumor resection areais calculated by accumulating the triangle area, which is more accurate.

The invention relates to medicaments that contain xenogenic oligo- or / and polyribonucleotides as the effective component. The invention further relates to the use of said xenogenic oligo- or / and polyribonucleotides for treating herpesviridae infections and skin tumors.

The invention discloses application of SHARPIN gene in the preparation of a reagent for diagnosing human skin tumors. Genome DNA sequence of the SHARPIN gene is as shown in SEQ ID NO. 1, a protein sequence is as shown in SEQ ID NO. 2, and SHARPIN gene mutation site is at c.103 with protein sequence mutation site at p.35, or SHARPIN gene mutation site is at c.329 with protein sequence mutation site at p.110, or SHARPIN gene mutation site is at c.214 with protein sequence mutation site at p.72, or SHARPIN gene mutation site is at c.221 with protein sequence mutation site at p.74, or SHARPIN gene mutation site at c.347 with protein sequence mutation site at p.116. The technical problem to be solved is to provide a method to assist in diagnosing NMSC (non-melanoma skin cancer) and application of SHARPIN GENE kit in the preparation of reagents for diagnosing human skin tumors.

The invention discloses a surgical planning system, including a controller, a laser marking device and an image acquisition device. A surgical cut path information is stored in that control, the lasermarking device is used for projecting the surgical cutting path information to a part to be operated of a patient through a laser, At least three laser marking device are provided, and that laser projections of all the laser marking devices on the part to be operated coincide with each other, and the image acquisition device is used for acquiring images and transmitting the images to a conveyingcontroller. The system can facilitate accurate excision of skin tumors by Mohs operation, and greatly reduces the possibility of residual pseudopodia of tumor cells.

The invention discloses an intelligent tracking method and system for a skin tumor precise surgery based on machine vision. The method comprises the following steps of conducting full-process high-definition shooting on the extraction process of a subcutaneous tissue slice and the re-excision process of a corresponding area of the subcutaneous tissue slice, and transmitting a shot video to a visual computing unit in real time; detecting and tracing a surgical blade by the visual computing unit according to the shot video, wherein specifically, the central point of a movement trajectory of thesurgical blade is calculated, then a corresponding surgical area is marked, a re-excision area is matched with a subcutaneous tissue slice extraction area, and a matching result is transmitted to a human-machine interaction unit; the human-machine interaction unit displays the matching result of the visual computing unit to a user, and simultaneously receives an operation instruction of the user and transmits the instruction to the visual computing unit. By means of the intelligent tracking method and system, the subcutaneous tissue slice extraction area and the re-excision area are marked bytracking the movement trajectory of the surgical blade, and the system is expected to replace a human assistant in large-area skin tumor excision surgeries.

Embodiments of the invention relate to a method of treating a cancerous or non-cancerous skin lesion of a subject, e.g. a human patient, by epidermal radioisotope therapy, a specialized type of brachytherapy. The method can include defining and marking an area of skin to be treated; covering the area with a protective layer, e.g. a protective film or foil; applying a tailor-made radioactive source by applying a layer of a radioactive source material on the protective layer, such that the area is covered by the material while any area not to be treated is spared; and removing the radioactive source after a predetermined time period of irradiation.

The present invention relates to the effect of naturally occurring compounds on tumor development. As an example of proof, we used low; non-toxic doses of three compound e.g. Calcium D-glucarate, a naturally occurring Ca++ salt of D-glucaric acid; Nicotinamide (NA), a naturally occurring vitamin and butyric acid (BA), a naturally occurring saturated short chain fatty acid. 7,12 dimethylbenzanthracene (DMBA), which is a very potent skin carcinogen and is an environmental pollutant, was used for skin tumor development. Experiment was performed up to 30 weeks. All the above-mentioned compounds were used either alone or concomitantly any two or all the three. In the positive control group 100% tumorigenesis was attained in 28 weeks, use of single compound led to the inhibition of DMBA induced tumorigenesis between 33 to 47%, use of two compounds resulted in the 73 to 80% reduction in tumorigenesis but the concomitant use of three compounds resulted into 100% inhibition of tumor development at the end of 30 weeks. This led us to conclude that the concomitant use of Cag, NA and BA in combination of two is useful for preventing skin tumor development for a sort or long period of time. But the concomitant use of all the three compounds, as described, exhibited the perfect synergistic effect in preventing the tumor development completely. This strategy should be equally effective in the management of benign and possibly malignant tumor in any organ caused by any mean.

The invention discloses an application of bacteroides fragilis combined with an immune checkpoint inhibitor in treatment of skin tumors, in particular to a bacteroides fragilis ZY-312 with the preservation number of CGMCC No.10685, and the bacteroides fragilis ZY-312 is combined with a PD-1 inhibitor for use, so that the comprehensive curative effect of treating the skin tumors can be remarkably improved; the bacteroides fragilis can effectively prevent and treat generation, development, relapse and metastasis of melanoma by reducing the levels of proinflammatory factors IL-1, IL-6, IL-8 and VEGF, increasing migration of CD8 + effector T cells, reducing recruitment of Treg cells, reducing the weight of in-situ tumors and increasing the cancer inhibition rate, the harm of radiotherapy and chemotherapy to organisms is relieved, and the living quality of patients is improved.

The invention relates to the preparation technology of drugs for treating skin tumors and neoplasm, and aims at providing a preparation for treating the skin tumors and neoplasm and a preparation method thereof. The preparation is an injection product for injection and comprises anatase TiO2-coated nano monocrystal lanthanum boride, gelatin and deionized water; physical and chemical properties ofthe anatase TiO2-coated nano monocrystal lanthanum boride are as follows: the color and density depend on a thickness of a anatase TiO2 coating layer, the color is pink or light purple, the anatase TiO2-coated nano monocrystal lanthanum boride is insoluble in water, and the density is 4.1 to 4.5 g / cm<3>. The main component anatase TiO2-coated nano monocrystal lanthanum boride of the injection is simple in synthetic process and suitable for the industrialized mass production. By adopting the preparation, the surface wound infection can be controlled, the wound can be promoted to be rapidly healed, and the wound can be prevented from being infected. The temperature of an affected part can rise to the gelling temperature of proteins by utilizing the sunlight, the tumor cells and neoplasm cells can be killed, and the treatment effect can be achieved. The preparation has no drug side effect, and is safe and convenient, capable of saving trouble and money, and wide in industrialized prospect.

The present invention relates to a compound or combination for use in the treatment of skin wounds, skin aging, skin tumors and / or skin sensation conditions and / or for treatment to improve skin repair, wherein the compound or combination is:(a) a selective delta-opioid receptor (DOR) antagonist; or(b) a combination of a selective DOR antagonist and an opioid receptor agonist; or(c) a selective ligand for a sensory receptor; or(d) a combination of a selective DOR antagonist and a selective ligand for a sensory receptor; or(e) a combination of a selective DOR antagonist, an opioid receptor agonist and a selective ligand for a sensory receptor, andwherein the treatment comprises a step of administering an effective amount of the compound or combination to a subject in need of such treatment.

The invention relates to a grading model for detecting benign and malignant degrees of skin tumors and application thereof. According to the model, changes of imprinting genes in tumors are graded bycalculating imprinting gene deletion expression quantity, imprinting gene copy number abnormal expression quantity and imprinting gene total expression quantity. According to the detection model and the device provided by the invention, the expression of the imprint deletion on the tissue and the cell sample of a skin tumor patient is represented by using the intuitive method, the imprint (trace)gene change is objectively, intuitively, early and accurately detected through adoption of an imprint gene in-situ labeling method, the quantitative model can be provided, and the great contribution is provided for the diagnosis of the skin tumor.

Methods, compositions and products for preventing skin tumor formation or inhibiting the development of an existing skin tumor in a subject are described. The methods involve administering to the subject a composition containing an α adrenergic receptor agonist, such as brimonidine.

The invention discloses a non-destructive detection system and method for skin tumors on the basis of a frequency modulation excitation thermal map. The system comprises a thermal infrared imager assembly, a thermal excitation source, a function signal generator, a light modulator and a data receiving and processing device; the thermal infrared imager assembly includes an infrared thermography head, and the thermal excitation source includes a halogen lamp head. The method includes the following steps of adjusting the position of the thermal infrared imager assembly; adjusting the focal lengthof the infrared thermography head until a clear infrared image is displayed; adjusting the thermal excitation source to converge lamp holder apertures in the thermal excitation source to a to-be-detected part; inputting and determining a frequency modulation signal in the data receiving and processing device, outputting the frequency modulation signal to the function signal generator and redetermining the frequency modulation signal in the function signal generator; turning on a halogen lamp assembly power source and collecting image data of the to-be-detected part. Compared with the prior art, the system and method in the scheme have the advantages that patients have no painful feeling in a diagnostic process, the detection cost is low, and a detection result is accurate and reliable.

A space for conducting photodynamic therapy (PDT) for treatment of skin diseases, especially for treatment of superficial skin tumors such as actinic keratoses, basal cell carcinomas, and initial carcinomas, wherein an active ingredient is applied to a skin area to be treated in order to form porphyrins and irradiation with light is conducted to form singlet oxygen based on the porphyrins in order to destroy diseased skin cells, wherein the space has side walls, a ceiling, and a floor, as well as at least two lighting fixtures, which are separated from one another by at least 50 cm and illuminate at least a subregion of the space, wherein there is an illuminance of at least 8,000 lux at every point in the subregion and the subregion has horizontal dimensions of at least 1 m2 and a vertical height of at least 40 cm. This invention also relates to a luminous ceiling system and method for conducting PDT.

The invention relates to the technical field of skin tumor resection supplies, and discloses a dividing device for tumor with pedicle on body surface. The device includes a box body, and the box bodyis provided with a control screen, a power-on interface, a fixed rod 1, a fixed rod 2, a fixed plate 1, a fixed plate 2, a movable cavity, a telescopic motor, a telescopic rod, a connecting rod, a slider hole 1, an extension plate, a strip-shaped hole, a blade and a coagulation plate. The device has a simple structure, a small size, and is easy to use and operate, only requires a medical staff tocomplete the tumor resection process. After the resection, the stump can be hemostatic immediately to save time and effort.

The invention discloses a fat-soluble photosensitizer, and a preparation method and application thereof. According to the invention, vitamin E derivatives and inorganic salts of the derivatives are combined with a photosensitizer for treating skin tumors, and skin collagen fibers can be repaired with the help of the protective effect of the vitamin E on healthy skins while tumor cells can be effectively killed, so that the side effects of medicines are greatly reduced. According to the fat-soluble photosensitizer disclosed by the invention, the drug metabolism rate is slowed, so that the drugeffect is more durable. The photosensitizer containing the vitamin E derivatives can generate more free radicals, so that the tumor cells can be killed more efficiently and quickly. The required dosage is far lower than a required dosage of 5-ALA used in the market, antibiotics are not contained, drug resistance is not generated, and the photosensitizer is safe, non-toxic, economical and practical.