21 results about "Skin tumor" patented technology

The utility model provides a honeycomb nanofiber-based flexible probe medical dressing, the shape of the medical dressing is a honeycomb formed by closely arranging hexagonal structure units, six edges of each hexagonal structure unit are detection parts, the middle surrounded part is a treatment part, and the detection parts are closely attached to the treatment part; the detection part is used for detecting the high active oxygen concentration of the wound and judging whether the wound is infected or not; the treatment part is used for treatment and infection resistance of wounds after skin tumor excision. The medical dressing is used for wound treatment and infection resistance after skin tumor excision, and meanwhile, the high active oxygen concentration of a wound is detected, and whether the wound is infected or not is judged.

The invention discloses a skin tumor classification feature acquisition method, and relates to the technical field of image recognition. Comprising the following steps: acquiring near infrared spectrum data and ultrasonic images of skin tumors, constructing a near infrared spectrum feature vector set and an ultrasonic image feature vector set, and generating skin tumor classification indexes and mixed skin tumor classification indexes of different feature vector sets through a regression model; constructing a multi-modal data fusion feature vector set, and screening the multi-modal data fusion feature vector set through a machine learning algorithm to obtain a screened feature set; and performing multi-factor regression analysis on the screening feature set to obtain a consistency analysis result range, and taking the screening features of which the consistency analysis result range is greater than a set threshold value as classification features. According to the method, manual key feature comparison and recording are not needed, and subjectivity and low efficiency of manual feature comparison can be avoided.

The invention relates to the field of dermatology, and provides a rapid skin tumor resection tool aiming at the technical problem that an existing resection device is low in use efficiency, the rapid skin tumor resection tool comprises a shell with the inner area divided into a front end cavity, a middle end cavity and a rear end cavity, a front cover and a rear cover are rotationally connected to the positions, located outside the front end cavity and the rear end cavity, of the shell, the cutting device is arranged in the shell, and the cutting device comprises a high-pressure gas driving module which is arranged in the rear end cavity and extends to the middle end cavity; the homologous driving type displacement and rotary excision module is arranged in the front end cavity and is communicated with the high-pressure gas driving module; and the synchronous collection module is arranged in the front-end cavity. High-pressure gas is adopted as a power source of the excision device, generated chippings and blood can be blown away in time, the surgical field is kept in a clean state all the time, the tumor can be rapidly and accurately excided, and the use efficiency is high.

The invention provides a separation microneedle of a loaded lipidosome nanoreactor as well as a preparation method and application of the separation microneedle, and belongs to the technical field of biological medicines. The preparation method comprises the following steps: by taking phospholipid, cholesterol, tetramethoxysilane and 3-aminopropyltriethoxysilane as raw materials, entrapping cis-platinum, 5-aminolevulinic acid and catalase to prepare a liposome nano-reactor; polyvinylpyrrolidone, citric acid, sodium bicarbonate and regenerated silk cellulose are used as raw materials, a liposome nano reactor is dispersed in a microneedle body through a pouring method, and the microneedle capable of being rapidly separated is successfully prepared. Experimental research proves that the separation microneedle has good biocompatibility and mechanical properties, can effectively break through cuticle and realizes efficient transdermal delivery of a liposome nanoreactor. The liposome nanoreactor can be locally planted in deep tumor tissues, continuously supplies oxygen through enzymatic reaction, effectively improves the difficulty of insufficient oxygen supply in tumor photodynamic therapy, and has obvious advantages and wide prospects in the aspects of skin tumor photodynamic therapy application and the like.

The invention discloses a soluble microneedle patch for skin tumors and a preparation method and application thereof, and belongs to the technical field of soluble microneedles, gel formed by a microneedle matrix which is excellent in biocompatibility and contains disulfide bonds is injected into a microneedle mold, and the soluble microneedle patch is prepared. Then vacuumizing, centrifuging, adding viscous microneedle substrate polyacrylic acid gel, and drying to obtain the specific soluble microneedle patch of which the dissolution rate in a tumor microenvironment is obviously higher than that of normal tissues. The microneedle matrix with disulfide bonds specifically responds to the high reducibility of a tumor microenvironment, the drug is rapidly broken and released, the drug release amount in a normal skin area is reduced, stimulation to healthy tissue is avoided, potential damage to normal tissue is reduced, and more accurate targeted therapy is achieved.

The present invention relates to a 2-amino-substituted derivative (Formula I) or an ethylenediamine-substituted derivative (Formulas II and III) of hypocrellin as a photodynamic drug for treating the following tumors: esophageal cancer, gastric cancer, lung cancer, liver cancer, cholangiocarcinoma, colon cancer cells related to digestive tract tumors; brain cancer, head and neck cancer, tongue cancer, nasal cancer, oral cancer, glioblastoma cells related to head, neck and facial tumors; basal cell carcinoma, squamous cell carcinoma, cutaneous T-cell lymphoma, melanoma cells related to skin tumors; prostate cancer, bladder cancer cells related to genitourinary tumors. At the same time, such derivatives can localize the location of tumor tissues through their own fluorescence and are used for fluorescence-guided surgical resection of tumors.

The invention relates to the technical field of hyperspectral three-dimensional reconstruction, in particular to a skin tumor layered structure three-dimensional reconstruction system based on a hyperspectral image. The system is used for collecting multi-source hyperspectral skin monitoring data; performing spectrum registration and fusion processing on the multi-source hyperspectral skin monitoring data to generate fused spectrum skin monitoring data; analyzing skin monitoring spectrum structure feature data based on the fused spectrum skin monitoring data; performing skin deep tissue component characterization characteristic analysis processing according to the skin monitoring spectrum structure characteristic data to generate skin deep tissue component characterization characteristic data; according to the skin deep tissue component characterization characteristic data, carrying out skin tumor layered structure characterization and flowing three-dimensional modeling processing to generate a skin tumor layered structure model; and performing skin tumor trend evolution processing on the skin tumor layered structure model to generate a skin tumor trend layered structure model. According to the invention, the three-dimensional modeling of the skin tumor layered structure with precise representation is realized.

The invention discloses a skin tumor three-dimensional electrical impedance tomography method and device and a storage medium. The method comprises the following steps: acquiring a skin surface boundary voltage signal by using a planar electrode, and generating a space virtual electrode equivalent voltage through nonlinear mapping from a planar electrode domain to a space virtual electrode domain; mapping the voltage into a two-dimensional voltage feature map through bilinear interpolation, inputting the feature as prior information into a three-dimensional electrical impedance imaging reconstruction network, and performing depth matching inversion on the body area conductivity distribution based on a sliding window SwinUNet network to obtain a three-dimensional conductivity image; constructing a skin tissue finite element model, and generating a simulation data set; and training nonlinear mapping by adopting the simulation data set and verifying the depth matching inversion performance. The method can still keep stable reconstruction quality under uncertain conditions such as poor electrode contact, channel loss and skin structure change, has high robustness and adaptability, and has good clinical application value.

The application provides a kind of liposome nano-reactor loaded separation microneedle and its preparation method and application, belong to the field of biological medicine.The application uses phospholipid, cholesterol, tetramethoxysilane and 3-aminopropyl triethoxysilane as raw material, encapsulates cisplatin, 5-aminoacetylpropionic acid and catalase, and prepares liposome nano-reactor;With polyvinylpyrrolidone, citric acid, sodium bicarbonate and regenerated silk fibroin as raw material, the liposome nano-reactor is dispersed in microneedle body by pouring method, and a kind of microneedle that can be quickly separated is successfully prepared.The experimental research of the application proves that the separation microneedle has good biocompatibility and mechanical property, can effectively break through the stratum corneum, realize the efficient transdermal delivery of liposome nano-reactor.The liposome nano-reactor can be locally planted in deep tissue of tumor, continuously supply oxygen through enzymatic reaction, effectively improve the oxygen supply shortage of tumor photodynamic therapy, and has obvious advantages and broad prospects in the application of skin tumor photodynamic therapy.

The present invention discloses a tumor identification and evaluation method, system and equipment based on multidimensional analysis, and relates to the technical field of tumor image recognition. The tumor identification and evaluation method based on multidimensional analysis includes the following steps: comprehensively analyzing and judging the skin tumor identification hidden danger level according to the skin canceration hidden danger results of the functional area of ​​human skin, the human skin skin color level correction results and the ambient light intensity correction results; determining the corresponding skin tumor warning scheme according to the skin tumor identification hidden danger level. The present invention achieves the effect of improving the accuracy of the method of multidimensional analysis of skin tumor images through the analysis of the hidden danger of canceration in the functional area of ​​human skin, the analysis of the influence of human skin skin color, the analysis of the influence of ambient light intensity, the judgment of the skin tumor identification hidden danger level and the determination of the skin tumor warning scheme, and solves the problem of insufficient accuracy of the method of multidimensional analysis of skin tumor images in the prior art.

This invention relates to a host defense peptide, Boma-CATH, from the giant toad (Toadus spp.), its gene, and its applications, belonging to the biomedical field. Boma-CATH is a polypeptide encoded by the defense peptide gene of the giant toad, an amphibian endemic to China. It has a molecular weight of 3124.38 Daltons and an isoelectric point of 5.2, and its amino acid sequence is shown in SEQ ID NO:1. The gene encoding the precursor of Boma-CATH (GenBank accession No. OR797636) consists of 690 nucleotide sequences, as shown in SEQ ID NO:2, where nucleotides 430–510 encode the mature giant toad host defense peptide, Boma-CATH. The giant toad host defense peptide Boma-CATH can be used to prepare drugs for treating skin tumors, including malignant melanoma and squamous cell carcinoma.

The utility model relates to the technical field of tumor radiation, and particularly discloses a head, neck and shoulder positioning auxiliary device which comprises a fixing base. The abutting seat is arranged at the top end of the fixed seat, a plurality of limiting insertion rods are arranged outside the abutting seat, a thermoplastic film is fixedly connected to the outside of the abutting seat, air holes are formed in the outside of the thermoplastic film, a plurality of irradiation holes are formed in the outside of the thermoplastic film, and a plurality of compensation films are buckled to the outside of the thermoplastic film; by means of the abutting seat, the limiting inserting rod, the thermoplastic film and the air holes, the air holes are formed outside the thermoplastic film, the mouth and nose of a patient can be exposed, the comfort degree of the patient after wearing is improved, the compensation film can be conveniently buckled outside the thermoplastic film, and the comfort degree of the patient is improved. And treatment operation can be performed on patients under different conditions, so that the comfort of the patients is ensured, and the skin tumor irradiation dose is also ensured.

The present invention discloses the application of a derivative with simultaneous substitution at the meso-position and 2-position of hypocrellin as a photodynamic drug in the photodynamic therapy of various tumors. The maximum absorption wavelength of such derivatives is around 630 nm, and the molar extinction coefficient can reach 20,000 - 40,000 M-1 cm-1, showing strong light absorption ability in the phototherapy window; under photosensitizing conditions, it can efficiently generate reactive oxygen species such as singlet oxygen. Such derivatives can efficiently kill a variety of tumor cells, such as esophageal cancer, gastric cancer, lung cancer, liver cancer, cholangiocarcinoma, and colon cancer cells related to digestive tract tumors; brain cancer, head and neck cancer, tongue cancer, nasal cancer, oral cancer, and glioblastoma cells related to head and neck tumors; basal cell carcinoma, squamous cell carcinoma, cutaneous T-cell lymphoma, and melanoma cells related to skin tumors; prostate cancer and bladder cancer cells related to genitourinary tumors. At the same time, such derivatives have good enrichment effects in various tumor cells, can specifically accumulate in tumor cells or tissues, and can locate the position of tumor tissues through the self-fluorescence of the photosensitizer, for fluorescence-guided surgical resection of tumors. Under the same conditions, the derivatives in the present invention have higher photodynamic effects in treating tumors than commercial porphyrin-based photosensitizing drugs.

This invention discloses the fabrication of a wearable microneedle sensor and its application in the early visual detection of in situ melanoma. The invention first prepares gold-etched cuprous oxide and silver-encapsulated nanoparticles, then loads them with the small molecule compound catechol, and finally combines this with microneedle technology to create a wearable microneedle sensor. This microneedle sensor integrates colorimetric visualization and surface-enhanced Raman scattering (SERS) dual-mode detection, enabling in-situ sampling of living organisms. It can reflect physiological states in real time and continuously, providing an effective approach for the early diagnosis of skin tumors such as melanoma.

The invention relates to a hypocrellin 2-site amino substituted derivative (formula I) or ethylenediamine substituted derivative (formula II and formula III) as a photodynamic drug for treating the following tumors: esophageal cancer, gastric cancer, lung cancer, liver cancer, bile duct cancer and colon cancer cells related to digestive tract tumors; brain cancer, head and neck cancer, tongue cancer, nasal cancer, oral cancer and brain glioma cells related to head, neck and face tumors; basal cell carcinoma, squamous skin carcinoma, skin T cell lymphoma and melanoma cells related to skin tumors; prostate cancer and bladder cancer cells related to genitourinary system tumors. Meanwhile, the derivative can locate the position of a tumor tissue through self-fluorescence and is used for fluorescence-guided tumor operation excision.

This invention belongs to the fields of terahertz technology, medicine, and oncology. It specifically discloses a system and method for detecting skin tumor heterogeneity based on terahertz time-domain spectroscopy. The system comprises: performing multi-point scanning of a tumor and surrounding normal tissue using a terahertz scanner to obtain terahertz time-domain signals, which are then converted into terahertz absorption curves. Multiple characteristic parameters are extracted from the terahertz absorption curves, and the curves at different scanning points within the tumor are compared to analyze the heterogeneity within the tumor. Simultaneously, the tumor curves are compared with those of normal tissue to analyze the heterogeneity between the two groups. This invention utilizes the non-ionizing and non-invasive characteristics of terahertz waves to non-invasively obtain terahertz spectral information of skin tumors, thereby accurately detecting heterogeneity within and between tumors.

The present invention relates to the technical field of computer-aided preoperative analysis, and discloses a surgical margin path generating method and system for tumor surgery and a storage medium. The method comprises: acquiring clinical pictures of a tumor, dermatoscopy pictures, and medical history information of patients; segmenting and extracting tumor boundaries from the dermatoscopy pictures by using a preset deep learning network model to obtain skin tumor boundaries under a dermoscope; registering the skin tumor boundaries with the clinical pictures to obtain target tumor boundaries; generating an initial surgical margin path according to the medical history information, the target tumor boundaries, and a preset path generating model; in the case of a benign tumor, smoothing the initial surgical margin path to generate a surgical margin path of a fusiform incision.

The invention relates to the technical field of medical instruments, in particular to a skin tumor surgery resection device which comprises a placing box and further comprises a distraction mechanism arranged in the placing box and used for adjusting the distraction force of the device according to the lifting degree of the device; the moving mechanism is arranged on one side of the distraction mechanism, and the moving mechanism adjusts the traction force of the device according to the distraction force of the device. Through the distraction mechanism, when a medical worker pushes and pulls a handle, a connecting rope is wound and unwound on the surface of a first vertical roller to drive the first vertical roller to rotate, and the first vertical roller is fixedly connected with a rotating gear; the rotating gear rotates to be meshed with the moving rack, the moving rack is pushed to do linear motion in the sliding groove, the moving rack drives the supporting frame to ascend and descend through the connecting block, the skin is expanded or retracted, the force transmission direction of the connecting cable is changed through the pulley assembly, the labor-saving effect is achieved, and handle operation is convenient.

The application relates to the technical field of data processing, and particularly discloses a heterogeneous data feature extraction method and system based on multi-modal information fusion, which comprises the following steps: S1, collecting multi-source pathological data, determining a skin tumor disease set and multiple disease pathological data, and acquiring historical patient data; S2, determining multiple historical staging data and disease development vectors of each skin tumor disease; S3, determining a disease course development vector of each patient of each disease staging label of each skin tumor disease; S4, calculating a label feature set of each disease staging label of each skin tumor disease and multiple staging-course feature sets; and S5, constructing a disease detection model and multiple disease course development prediction models of each skin tumor disease. The core features of diseases and stages can be accurately refined, full-chain information support from disease identification, stage judgment to progress prediction is provided for the clinic, and the accuracy and foresight of skin tumor diagnosis and treatment are improved.

The application provides a flexible irreversible electroporation electrode patch for skin tumor treatment, which comprises a flexible electrode body, an electrode fixing adhesive, a release film, a cable fixing adhesive, a cable and a terminal. The flexible electrode body is composed of a 10-30 mu m thick polyimide film (PI) insulating substrate and a cover film clamping etched copper foil conductive circuit, the two ends of the circuit are respectively connected with a flexible conductive contact and a cable, the electrode fixing adhesive (diameter 50 mm with 3 split grooves) and the cable fixing adhesive respectively fix the patch and the cable, and the terminal is connected with a treatment host. The working electrode (4 evenly distributed in a 14-20 mm distribution circle) can be combined and switched in multiple groups, and is suitable for different sizes of skin tumors. The flexible electrode patch has good flexibility and stable fixation, can accurately control the electric field and the ablation range, avoids current mis-conduction, ensures safe and efficient treatment, and provides a special electrode scheme with strong adaptability and remarkable curative effect for irreversible electroporation treatment of skin tumors.

The invention relates to the technical field of data processing, and particularly discloses a heterogeneous data feature extraction method and system based on multi-modal information fusion, and the method comprises the steps: S1, collecting multi-source pathological data, determining a skin tumor disease set and multiple pieces of disease pathological data, and obtaining historical patient data; s2, determining a plurality of historical stage data and disease development vectors of each skin tumor disease; s3, determining a disease course development vector of each patient of each disease stage tag of each skin tumor disease; s4, calculating a label feature set of each disease stage label of each skin tumor disease and a plurality of stage-disease course feature sets; and S5, constructing a disease detection model, and constructing a plurality of disease course development prediction models of each skin tumor disease. Core features of various diseases and stages can be accurately extracted, full-chain information support from disease recognition, stage judgment to progress pre-judgment is provided for clinic, and the accuracy and foresight of skin tumor diagnosis and treatment are improved.