Small organometallic probes

a technology of organometallic probes and probes, which is applied in the field of small organometallic probes, can solve the problems of low targeting of gold, affecting the stability of the probe,
US20050130207A1Inactive Publication Date: 2005-06-16HAINFELD JAMES F +2
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
HAINFELD JAMES F
Publication Date
2005-06-16
Estimated Expiration
Not applicable · inactive patent

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Abstract

Small organometallic probes comprise a core of metal atoms bonded to organic moieties. The metal atoms are gold, silver, platinum, palladium, or combinations thereof. In one embodiment, a multifunctional organometallic probe comprises a core of metal atoms surrounded by a shell of organic moieties covalently attached to the metal atoms, a fluorescent molecule, e.g., fluorescein, covalently attached to one of the organic moieties, and a targeting molecule, e.g., an antibody, covalently attached to another of the organic moieties.
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Description

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application is a continuation of copending U.S. patent application Ser. No. 10 / 093,770, filed Mar. 8, 2002; which is a continuation-in-part of application Ser. No. 09 / 619,343, filed Jul. 19, 2000 and issued as U.S. Pat. No. 6,369,206; which is a divisional of application Ser. No. 09 / 039,601, filed Mar. 16, 1998 and issued as U.S. Pat. No. 6,121,425; which is a continuation-in-part of application Ser. No. 08 / 652,007, filed May 23, 1996 and issued as U.S. Pat. No. 5,728,590; which is a continuation-in-part of application Ser. No. 08 / 282,929, filed Jul. 29, 1994 and issued as U.S. Pat. No. 5,521,289.BACKGROUND OF THE INVENTION

[0002] The present invention is directed to small organometallic probes, processes for making the small organometallic probes, and applications of the small organometallic probes. In particular, the small organometallic probes of the present invention are generally less than two microns (2 μm) across, and compri...

Claims

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