Optimized proteins that target Ep-CAM

a technology of epithelial cells and proteins, applied in the field of optimized proteins that target epithelial cells, can solve the problems of unsatisfactory potency of curretly available antibodies as anti-cancer agents, limited in vivo accessibility of ep-cam, and other problems, to achieve the effect of increasing activation, increasing activation, and increasing binding to an activating cell
US20070122406A1Inactive Publication Date: 2007-05-31XENCOR
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
XENCOR
Publication Date
2007-05-31
Estimated Expiration
Not applicable · inactive patent

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Abstract

Humanized Ep-CAM-targeting antibodies and methods of making and using the same are provided.
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Description

[0001] This application claims benefit under 35 U.S.C. §119(e) to U.S. Ser. No. 60 / 697,768 filed Jul. 8, 2005, U.S. Ser. No. 60 / 741,966 filed Dec. 2, 2005, U.S. Ser. No. 60 / 779,961 filed Mar. 6, 2006, and U.S. Ser. No. 60 / 745,078 filed Apr. 18, 2006, each of which is expressly incorporated by reference in its entirety.FIELD OF THE INVENTION

[0002] The present invention relates to optimized proteins that target the epithelial cell adhesion molecule (Ep-CAM), and their applications, particularly for therapeutic purposes. BACKGROUND OF THE INVENTION

[0003] Epithelial cell adhesion molecule, also known as epithelial glycoprotein 40 [EGP40], epithelial protein 2 [EGP-2], GA733-2, ESA, KSA, 17-1A antigen or other names) is an epithelial transmembrane protein encoded by the GA 733-2 gene (Gottlinger, H. G. et al. 1986, Int. J. Cancer. 15: 47-53; Linnenbach, A. J. et al. 1989, Proc. Natl. Acad. Sci. USA. 86:27-31; Armstrong, A. and Eck, S. 2003. Cancer Biol. Ther. 2: 320-325, Linnenbach, A....

Claims

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