Cattle reproductive disease vaccines
a technology for bvdv vaccines and cattle, which is applied in the field of conjugated vaccines, can solve the problems of inactivated bvdv vaccines, inability to protect the fetus from infection, and inability to achieve fetal protection with inactivated bvdv vaccines
Examples
example 1
Materials and Methods
[0065] Animals—Fifty-six BVDV seronegative (i.e., having serum neutralization [SN] titers <1:2) cows suitable for breeding were obtained from multiple sources and maintained in research isolation facilities for the duration of the study. Each animal was identified with duplicate ear tags, one placed in each ear. New tags were installed in cases where an animal lost an ear tag. Prior to the study, test animals were inoculated with commercial vaccines for leptospirosis, campylobacteriosis (vibriosis), and clostridial infections. Test animals were maintained under supervision of an attending veterinarian, who clinically monitored them on a daily basis.
[0066] Test Vaccine—
[0067] The test vaccine was a multivalent, modified live infectious bovine rhinotracheitis (IBR)-parainfluenza 3 (PI3)-respiratory syncytial virus (RSV) vaccine in desiccated form, rehydrated with an inactivated, liquid BVDV vaccine combined with an adjuvant. (Pfizer Inc, New York, N.Y.) The BVDV...
example 2
Materials and Methods
[0099] Animals—Fifty-nine BVDV seronegative (i.e., having serum neutralization [SN] titers <1:2) cows and heifers of breeding age and soundness were obtained from multiple sources and maintained in isolation at research facilities in Nebraska for the duration of the study. Each animal was identified with duplicate ear tags, one placed in each ear. New tags were installed in cases where an animal lost an ear tag. Prior to the study, test animals were inoculated with commercial vaccines for leptospirosis, campylobacteriosis (vibriosis), and clostridial infections. Test animals were maintained under supervision of an attending veterinarian, who clinically monitored them on a daily basis.
[0100] Test Vaccine—The test vaccine was a multivalent, modified live infectious bovine rhinotracheitis (IBR)-parainfluenza 3 (PI3)-respiratory syncytial virus (RSV) vaccine in desiccated form, rehydrated with an inactivated, liquid BVDV vaccine (CattleMaster / PregSure 5, Pfizer In...
example 3
[0125] Two groups of 16 cattle were vaccinated twice subcutaneously at an interval of 3 weeks with 2 mL of L. hardjo / L. pomona combination vaccines prepared from two adjuvant formulations: 1) 2.5% Amphigen with Quil A / cholesterol each at 250 mcg / mL, and 2) Amphigen / AI-gel. The vaccines consisted of killed leptospires from which the culture fluids had been removed, so free endotoxin was low. Body temperatures, injection-site reactions, and general health observations were recorded following both injections. No systemic affects were seen, and local reactions were minimal and judged to be clinically acceptable. Sixteen additional cattle were injected with saline as controls. Four weeks after vaccination, cattle were challenged by ocular and vaginal instillation of 5×106 leptospires on 3 consecutive days. Half of each treatment group was challenged with serovar hardjo and half with pomona. Two pomona controls were eliminated from the study for unrelated reasons, leaving 6 animals in tha...
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Abstract
Description
Claims
Application Information
- IPC
- A61K39/12; A61P31/20; A61K39/00; A61K39/02; A61K39/155; A61K39/265; A61K39/295; C07K14/115; C07K14/135; C07K14/18
- CPC
- A61K39/00; A61K39/0225; A61K39/295; A61K39/39; A61K2039/5252; A61K2039/5254; C12N2770/28022; C12N2710/16722
- Inventors
- DOMINOWSKI, PAUL JOSEPH