Unlock instant, AI-driven research and patent intelligence for your innovation.

Hemostatic sponge

a sponge and hematopoietic technology, applied in the field of hematopoietic sponges, can solve the problems of difficult application of such particles directly onto bleeding wounds, inability to induce hemostasis of fibrous biomaterials, and difficulty in removing clotting factors, etc., to achieve improved hemostasis, high concentration of clotting factors, and high absorbibility.

Inactive Publication Date: 2015-05-14
BAXTER INT INC +1
View PDF8 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The sponge effectively improves hemostasis by maintaining a high concentration of clotting factors and adhering particles to the sponge, preventing detachment and enhancing durability and shelf life, while allowing flexible application to various tissues and locations.

Problems solved by technology

It has been found that previous pads of fibrous biomaterials, in particular collagen pads, for wound healing failed to induce hemostasis at conditions with impaired hemostasis (e.g. after heparinization).
It is difficult to apply such particles directly onto the bleeding wound because the particles tend to flow away with the bloodstream.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

example 1

Collagen Sponge Containing Cross-Linked Gelatin Particles

[0050]A homogeneous suspension containing 80 mg / ml of cross-linked gelatin particles and 2.1 mg / ml of collagen is prepared by stirring. This suspension is filled into a tray (layer thickness 3.5 mm) and freeze-dried. A collagen sponge containing entrapped cross-linked gelatin particles is obtained.

example 2

Collagen Sponge Containing Cross-Linked Gelatin Particles Discontinuously Coated with an Adhesive Layer

[0051]A collagen sponge containing cross-linked gelatin particles is prepared according to example 1. After freeze-drying a grid is laid onto the obtained product. 14 mg / cm2 of a 1:1 (w / w) powder mixture of two cross-linkable polyethyleneglycol polymers (PEG-A and PEG-B) are applied over the grid onto the pad. Only the holes of the grid are covered by the powder mixture. The powder is fixed on the pad by short (2-5 min) heating at a temperature higher than the melting point of the PEG components. The grid is removed and a pad with a discontinuous reactive PEG-coating is obtained. PEG-A is a PEG-succinimidyl powder, PEG-B is a PEG-thiol powder.

example 3

[0052]Hemostatic pad composed of the composition described in example 2 enforced by an additional supporting collagen layer. A 3.5 mm thickness layer of a 10 mg / ml of collagen suspension is filled into a tray and frozen at −20° C. for 1 h. The frozen collagen layer is coated by a 3.5 mm layer of the mixture described in example 3. The two layers are subsequently freeze-dried and the upper layer coated discontinuously with cross-linkable PEG components as described in example 2. The obtained layered pad has more mechanical robustness than the pads described in examples 1 and 2.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
sizeaaaaaaaaaa
particle sizeaaaaaaaaaa
diameteraaaaaaaaaa
Login to View More

Abstract

The present invention provides a hemostatic porous sponge comprising a matrix of a fibrous biomaterial and particles of a fluid absorbing, particulate material adhered to said matrix material, a method of producing these sponges and their use for wound healing.

Description

CROSS-REFERENCES TO RELATED APPLICATIONS[0001]This application is a continuation of and claims priority to U.S. patent application Ser. No. 12 / 816,645 filed Jun. 16, 2010, which claims the benefit of Provisional Application No. 61 / 187,576 filed Jun. 16, 2009, the entire contents of both of which are hereby incorporated by reference for all purposes.FIELD OF THE INVENTION[0002]The present invention relates to the field of hemostatic sponges, a method of producing said sponges and their uses in hemostasis.BACKGROUND OF THE INVENTION[0003]Biological glues based on coagulation factors of human or animal origin have long been known. A method for producing tissue adhesives based on fibrinogen and factor XIII has been described in U.S. Pat. No. 4,362,567, U.S. Pat. No. 4,298,598 and U.S. Pat. No. 4,377,572. The tissue adhesives are usually applied together with a separate component containing thrombin, which is enzymatically acting on fibrinogen to form fibrin, and on factor XIII to form t...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(United States)
IPC IPC(8): A61L15/42A61L15/26A61L15/58A61L15/64A61L15/32A61L15/44
CPCA61L15/425A61L15/325A61L15/44A61L15/32A61L2400/04A61L15/64A61L15/26A61L2300/418A61L15/58A61L26/00
Inventor HOEFINGHOFF, JORISHEDRICH, HANS CHRISTIAN
Owner BAXTER INT INC